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Fluzone: Influenza virus vaccine

Phase 2

Influenza | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Apr 14, 2016

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLEDDMC
Total Trials1
Total Enrollment110

FDA Designations

No designations recorded

Clinical trial landscape

Fluzone: Influenza virus vaccine · 1 trial · 1 indication

Phase 2 1
NCT00623181Study to Determine a Preference for Fluzone Vaccine Given Intradermally (ID) and Intramuscularly (IM) in Healthy AdultsInfluenza
COMPLETED110 Analytics
PHASE2COMPLETED
Study to Determine a Preference for Fluzone Vaccine Given Intradermally (ID) and Intramuscularly (IM) in Healthy Adults
InfluenzaUnlock trial analytics

Study Endpoints

Primary Endpoints

Categorical Summary of Pain or Other Discomfort Immediately After Vaccination and on Days 3 and 7 Post-vaccination
Day 0 and up to 7 days post-vaccination

Pain or other discomfort was assessed on a scale of 0 to 10 (None = 0; Hardly Any = 1, 2; Mild = 3, 4; Moderate = 5, 6; Severe = 7, 8; Unbearable = 9, 10) according to route of administration: intradermal (ID) as Group 1 and intramuscular (IM) as Group 2. Data for this outcome were combined for responses following a similar type of vaccination route in the entire study population.

Continuous Summary of Pain or Other Discomfort Immediately After Vaccination and on Days 3 and 7 Post-vaccination
Days 0, 3, and 7 after vaccination

Numerical scores were assigned to pain by participants on the preference questionnaire as: None = 0; Hardly Any = 1, 2; Mild = 3, 4; Moderate = 5, 6; Severe = 7, 8; or Unbearable = 9, 10. Data for this outcome were combined for responses following a similar type of vaccination route in the entire study population.

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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Fluzone Intradermal First, Then Fluzone IntramuscularEXPERIMENTAL -
Fluzone Intramuscular First, Then Fluzone IntradermalEXPERIMENTAL -

Interventions

NameTypeDescription
Fluzone: Influenza virus vaccineBIOLOGICAL0.1 mL, Intradermal Right deltoid, 0.5 mL, Intramuscular Left deltoid
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Eligibility Criteria

Age Range18 Years to 49 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Healthy male or female subject (can have underlying medical condition, as long as they are stable), greater than or equal to 18 to \< 50 years of age on the day of inclusion. * Informed consent form signed. * Able to attend both scheduled visits and to comply with all trial pr...

Countries:United States
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Frequently asked questions about Fluzone: Influenza virus vaccine

What is Fluzone used for?

Fluzone is an influenza virus vaccine used to prevent influenza. It is being studied in healthy adults in the United States. The vaccine is administered either intradermally or intramuscularly, and a clinical trial is evaluating patient preference for these two routes of administration.

Who makes Fluzone?

Fluzone is developed by Sanofi, a company listed on the stock exchange under the ticker SNY. Sanofi is conducting clinical research on this influenza vaccine to assess its use in healthy adult populations.

What phase is Fluzone in?

Fluzone is in Phase 2 clinical development. A Phase 2 trial has been completed, which studied the vaccine in healthy adults for the prevention of influenza. The vaccine remains investigational and is not yet approved for widespread use.

What clinical trials is Fluzone in?

Fluzone has one completed Phase 2 clinical trial registered under NCT00623181. This study, titled "Study to Determine a Preference for Fluzone Vaccine Given Intradermally (ID) and Intramuscularly (IM) in Healthy Adults," enrolled 110 participants in the United States. The trial was controlled but not double-blinded.

Is Fluzone the same as the influenza virus vaccine?

Yes, Fluzone is an influenza virus vaccine. It is designed to protect against influenza, a viral infection of the respiratory tract. The vaccine is being evaluated in clinical trials to determine its effectiveness and tolerability in healthy adults.