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A/H5N1 inactivated, split-virion influenza virus

Phase 2

Influenza | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Jan 14, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials2
Total Enrollment700
FDA Designations
FAST_TRACKORPHAN_DRUG
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00545701Immunogenicity and Safety of an Intramuscular A/H5N1 Inactivated, Split Virion Pandemic Influenza Vaccine in AdultsPHASE2 COMPLETED 100Oct 1, 2007Sep 1, 2008Jan 14, 20142 Australia
NCT00415129Safety and Immunogenicity of an Intramuscular Pandemic Influenza Vaccine in Adults and the ElderlyPHASE2 COMPLETED 600Jun 1, 2006Mar 1, 2009Jan 14, 20144 Belgium, United Kingdom
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Study Endpoints
Primary Endpoints
To provide information concerning the immunogenicity of A/H5N1 inactivated, split-virion influenza virus vaccine
Day 42 post-vaccination 1
To provide information concerning the safety of an A/H5N1 inactivated, split-virion influenza virus vaccine
21 Days post-vaccination
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
Study Group 1EXPERIMENTALVaccine with adjuvant
Study Group 2EXPERIMENTALVaccine without adjuvant
Interventions
NameTypeDescription
A/H5N1 inactivated, split-virion influenza virusBIOLOGICAL0.5 mL, Intramuscular
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Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Aged 18 to 60 years on day of inclusion. * Informed Consent Form signed. * Able to attend all scheduled visits and to comply with all trial procedures. * For a woman, inability to bear a child or negative urine pregnancy test. * For a woman of child-bearing potential, use of a...

Countries:AustraliaBelgiumUnited Kingdom
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