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2011 to 2012 Trivalent Influenza Vaccine

Phase 3

Influenza | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Mar 29, 2013

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment1,701

FDA Designations

No designations recorded

Clinical trial landscape

2011 to 2012 Trivalent Influenza Vaccine · 1 trial · 1 indication

Phase 3 1
NCT01481454Study of a Quadrivalent Influenza Vaccine Administered Intramuscularly in Children/Adolescents and AdultsInfluenza
COMPLETED1,701 Analytics
PHASE3COMPLETED
Study of a Quadrivalent Influenza Vaccine Administered Intramuscularly in Children/Adolescents and Adults
InfluenzaUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of participants reporting solicited injection site reactions and solicited systemic reactions during the trial
Day 0 to 7 post-vaccination

Solicited Injection Site Reactions: Pain, Erythema, Swelling, Induration, and Ecchymosis. Solicited Systemic Reactions: Fever (Temperature), Headache, Malaise, Myalgia, and Shivering

Percentage of participants reporting unsolicited systemic reactions including serious adverse events (SAE) throughout the trial.
Day 0 up to six months post-vaccination

An SAE is defined as any untoward medical occurrence that at any dose (including overdose): Results in death; Is life-threatening; Requires inpatient hospitalization or prolongation of existing hospitalization; Results in persistent or significant disability / incapacity; Is a congenital anomaly / birth defect; Is an important medical event.

Secondary Endpoints

Percentage of participants with seroprotection and seroconversion post vaccination with either the investigational QIV, or TIV or the licensed 2011-2012 TIV
Day 21 post-vaccination
Level of anti-hemagglutinin antibody titers for each of the 4 strains for each lot of the investigational QIV vaccine.
21 Days post-vaccination
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Group 1: QIV Lot 1EXPERIMENTALParticipants will receive the Quadrivalent Influenza Vaccine (QIV) from Lot 1.
Group 2: QIV Lot 2EXPERIMENTALParticipants will receive the Quadrivalent Influenza Vaccine (QIV) from Lot 2.
Group 3: QIV Lot 3EXPERIMENTALParticipants will receive the Quadrivalent Influenza Vaccine (QIV) from Lot 3.
Group 4: TIVACTIVE_COMPARATORParticipants will receive the Trivalent Influenza Vaccine (TIV).

Interventions

NameTypeDescription
Quadrivalent Influenza Vaccine (split virion, inactivated)BIOLOGICAL0.5 mL, Intramuscular
2011 to 2012 Trivalent Influenza VaccineBIOLOGICAL0.5 mL, Intramuscular
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Eligibility Criteria

Age Range9 Years to 60 Years
SexALL
Healthy VolunteersYes
Study Sites6

Inclusion Criteria: * Aged 9 to 11 years (children), 12 to 17 years (adolescents), or 18 to 60 years (adults) on the day of inclusion * For child/adolescent subjects, informed consent form has been signed and dated by the parent(s) (and subject, if applicable by local regulations), or another legal...

Countries:AustraliaPhilippines
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Frequently asked questions about 2011 to 2012 Trivalent Influenza Vaccine

What is 2011 to 2012 Trivalent Influenza Vaccine used for?

2011 to 2012 Trivalent Influenza Vaccine is an investigational vaccine being studied for the prevention of influenza. It is a trivalent formulation designed to protect against three influenza strains. The vaccine is currently in Phase 3 clinical development and is not yet approved by regulatory authorities.

Who makes 2011 to 2012 Trivalent Influenza Vaccine?

2011 to 2012 Trivalent Influenza Vaccine is being developed by Sanofi, a global biopharmaceutical company listed on the stock exchange under the ticker SNY. Sanofi is conducting clinical trials to evaluate the safety and efficacy of this investigational influenza vaccine.

What phase is 2011 to 2012 Trivalent Influenza Vaccine in?

2011 to 2012 Trivalent Influenza Vaccine is in Phase 3 clinical development. It is an investigational vaccine and has not yet received regulatory approval. The Phase 3 trial has been completed, and the vaccine remains under evaluation for the prevention of influenza.

What clinical trials is 2011 to 2012 Trivalent Influenza Vaccine in?

2011 to 2012 Trivalent Influenza Vaccine was studied in a Phase 3 clinical trial registered as NCT01481454. This completed trial enrolled 1,701 participants aged 9 years and older in Australia and the Philippines. The study was randomized, double-blind, and active-controlled, evaluating the vaccine's safety and immunogenicity.

Is 2011 to 2012 Trivalent Influenza Vaccine the same as a quadrivalent influenza vaccine?

2011 to 2012 Trivalent Influenza Vaccine is a trivalent vaccine, meaning it targets three influenza strains. The clinical trial NCT01481454 studied a quadrivalent influenza vaccine, which targets four strains. These are different vaccine formulations, though both are being developed for influenza prevention.