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vadimezan

Phase 3

Advanced or Recurrent Solid Tumors | Small molecule | Oncology |Novartis AG|Trials Updated: Dec 9, 2020

vadimezan development status

Highest phase Phase 3 (NCT00738387)
Phase scored for NVSPhase 1
Registered trials 10 across 2 sponsors since Apr 2008

vadimezan target and mechanism

ModalitySmall molecule

Also known as ASA404

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials2
Total Enrollment24

FDA Designations

No designations recorded

vadimezan clinical trials

vadimezan · 2 trials · 2 indications

Phase 1 2
NCT01285453Safety and Tolerability of ASA404 Administered in Combination With Docetaxel in Japanese Patients With Solid TumorsAdvanced or Recurrent Solid Tumors
COMPLETED9 Analytics
NCT00674102An Open-label, Phase I Trial of Intravenous ASA404 Administered in Combination With Paclitaxel and Carboplatin in Japanese Patients With Non-Small Cell Lung Cancer (NSCLC)Non-small Cell Lung Cancer
COMPLETED15 Analytics
PHASE1COMPLETED
Safety and Tolerability of ASA404 Administered in Combination With Docetaxel in Japanese Patients With Solid Tumors
Advanced or Recurrent Solid TumorsUnlock trial analytics
PHASE1COMPLETED
An Open-label, Phase I Trial of Intravenous ASA404 Administered in Combination With Paclitaxel and Carboplatin in Japanese Patients With Non-Small Cell Lung Cancer (NSCLC)
Non-small Cell Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To assess the safety profile and tolerability of ASA404 when administered in combination with paclitaxel and carboplatin in Japanese patients with non small cell lung cancer
First cycle

Secondary Endpoints

To characterize the pharmacokinetics profile of ASA404 in Japanese patients
every 2 cycles
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ASA404EXPERIMENTAL -

Interventions

NameTypeDescription
vadimezanDRUG -
ASA404DRUG -
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Eligibility Criteria

Age Range20 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: 1. Patients with confirmed solid tumors whose disease has progressed or recurred after treatment at lease one therapy, except docetaxel 2. WHO Performance Status of 0-1 Exclusion Criteria: 1. Patients having symptomatic CNS tumor/metastasis and requiring treatment 2. Patients ...

Countries:Japan
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Competitive Landscape -Other Solid Tumors 10 trials (matched to "Advanced or Recurrent Solid Tumors")

Frequently asked questions about vadimezan

What is vadimezan used for?

Vadimezan is an investigational small molecule being studied for the treatment of advanced or recurrent solid tumors. It is an oncology drug candidate developed by Novartis AG. As of the available data, vadimezan is in Phase 1 clinical development and has not been approved by regulatory authorities.

Who makes vadimezan?

Vadimezan is being developed by Novartis AG, a multinational pharmaceutical company traded on the New York Stock Exchange under the ticker symbol NVS. The drug is an investigational small molecule intended for the treatment of advanced or recurrent solid tumors.

What phase is vadimezan in?

Vadimezan is in Phase 1 clinical development. It is an investigational drug and has not received regulatory approval. The drug is being studied for the treatment of advanced or recurrent solid tumors, and its clinical development is still in the early stages.

What clinical trials is vadimezan in?

Vadimezan has one completed clinical trial registered under NCT01285453, titled "Safety and Tolerability of ASA404 Administered in Combination With Docetaxel in Japanese Patients With Solid Tumors." This Phase 1 study enrolled 9 participants with advanced or recurrent solid tumors in Japan.

Is vadimezan the same as ASA404?

Vadimezan is also known as ASA404. The clinical trial NCT01285453 refers to the drug as ASA404, indicating that vadimezan and ASA404 are alternative names for the same investigational compound being developed by Novartis AG.