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MF59 adjuvanted H5N1 influenza vaccine

Phase 2

Influenza | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Dec 1, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLED
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00382187Safety and Immunogenicity of Two Adjuvanted and One Non-adjuvanted H5N1 Influenza Vaccine in AdultsPHASE2 COMPLETED 40Nov 1, 2006Jan 1, 2008Dec 1, 20161 Italy
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Study Endpoints
Primary Endpoints
CPMP criteria for evaluation of flu vaccines e.g. Seroprotection, GMT's and Seroconversion rate at day 0 and day 22 and day 43 following vaccination.
day 1 to day 43
Secondary Endpoints
Solicited Local and Systemic Reactions Within 6 Days Following Each Vaccination And Adverse Events Throughout the Study.
Day 1 to Day 382
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
MF59 adjuvant H5N1 influenza vaccine 7.5 microgramsEXPERIMENTAL -
MF59 adjuvant H5N1 influenza vaccine 15 microgramsEXPERIMENTAL -
non-adjuvanted influenza vaccine 15 micrograms of H5N1 antigenEXPERIMENTAL -
Interventions
NameTypeDescription
MF59 adjuvanted H5N1 influenza vaccineBIOLOGICAL* MF59 adjuvanted (H5N1) influenza vaccine (Vietnam strain) containing 7.5 mg or 15 mg of H5N1 * non-adjuvanted influenza vaccine containing 15 ug of H5N1
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Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male and female volunteers 18-60 years of age Exclusion Criteria: * Any auto-immune disease or other serious acute, chronic or progressive disease * Hypersensitivity to eggs, chicken protein, chicken feathers, influenza viral protein, neomycin or polymyxin or any other compo...

Countries:Italy
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