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Influenza Trivalent Inactivated vaccines Novartis

Phase 2

Influenza | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Apr 7, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment360
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00649883Safety and Immunogenicity of Two 0.25 mL or 0.5 mL Doses of Two Different Influenza Vaccines in Healthy Children Aged 6 to <60 MonthsPHASE2 COMPLETED 360Jan 1, 2008Oct 1, 2008Apr 7, 20175 Guatemala
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Study Endpoints
Primary Endpoints
To evaluate the safety and tolerability of one and two doses of investigational vaccines or active control influenza vaccine in unprimed healthy children aged 6 months to <36 months.
211 days
Secondary Endpoints
To evaluate the immunogenicity of two doses of investigational influenza vaccine or active control influenza vaccines, as measured by HI assay in children aged 36 to <60 months.
211 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Influenza Trivalent Inactivated vaccines NovartisBIOLOGICALChildren 6 to \<36 months of age will receive two 0.25 mL doses, and children 36 to \<60 months of age will receive two 0.5 mL doses of investigational influenza vaccine, administered four weeks apart intramuscularly (IM) in the deltoid muscle preferably of the non-dominant arm.
Influenza Trivalent Inactivated vaccinesBIOLOGICALChildren 6 to \<36 months of age will receive two 0.25 mL doses, and children 36 to \<60 months of age will receive two 0.5 mL doses of active control influenza vaccine, administered four weeks apart intramuscularly (IM) in the deltoid muscle preferably of the non-dominant arm.
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Eligibility Criteria
Age Range6 Months — 59 Months
SexALL
Healthy VolunteersYes
Study Sites5

Inclusion Criteria: * Children of 6 to \<60 months of age, whose parents/legal guardians have given written informed consent prior to study entry. * In good health as determined by: medical history, physical examination, clinical judgment of the investigator. * Able to comply with all study procedu...

Countries:Guatemala
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