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ACE-536

Phase 1

Anemia | Monoclonal antibody | Hematology |Merck & Company, Inc.|Last Updated: Nov 7, 2012

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

ACE-536 · 1 trial · 1 indication

Phase 1 1
NCT01432717Study of ACE-536 in Healthy Postmenopausal WomenAnemia
COMPLETED40 Analytics
PHASE1COMPLETED
Study of ACE-536 in Healthy Postmenopausal Women
AnemiaUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with Adverse Events as a measure of safety and tolerability.
22 weeks

Secondary Endpoints

ACE-536 serum concentration after single and multiple ascending doses.
22 weeks
Hemoglobin levels after single and multiple ascending doses.
22 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ACE-536EXPERIMENTALSubjects assigned to 1 of 5 possible dosing groups.
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
ACE-536BIOLOGICALSubjects receive a total of 2 subcutaneous doses of ACE-536 on Day 1 and Day 15.
PlaceboOTHERSubjects receive a total of 2 subcutaneous doses of placebo on Day 1 and Day 15.
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Eligibility Criteria

Age Range45 Years to 75 Years
SexFEMALE
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Postmenopausal women * Body Mass Index (BMI) of 20 - 32 kg/m2. Key Exclusion Criteria: * History of hypertension * Subject has received any erythropoiesis stimulating agents (e.g., Epogen, Procrit, Aranesp, etc.) within 6 months prior to Day 1 * History of clinically sig...

Countries:United States
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Frequently asked questions about ACE-536

What is ACE-536 used for?

ACE-536 is an investigational monoclonal antibody being developed for the treatment of anemia. It is currently in Phase 1 clinical development, meaning it has not yet been approved by regulatory authorities. The drug is being studied in the therapeutic area of hematology.

Who makes ACE-536?

ACE-536 is being developed by Merck & Company, Inc., a pharmaceutical company traded on the New York Stock Exchange under the ticker symbol MRK. The drug is currently in Phase 1 clinical development for the treatment of anemia.

What phase is ACE-536 in?

ACE-536 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug is being studied for the treatment of anemia, and its Phase 1 trial has been completed.

What clinical trials is ACE-536 in?

ACE-536 has one completed Phase 1 clinical trial with the identifier NCT01432717, titled 'Study of ACE-536 in Healthy Postmenopausal Women.' This trial enrolled 40 participants in the United States and was a randomized, double-blind, placebo-controlled study.

Is ACE-536 FDA approved?

ACE-536 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development for the treatment of anemia. The drug has completed one Phase 1 trial, but it has not yet received regulatory approval.