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ACE-536

Phase 1

Anemia | Monoclonal antibody | Hematology |Merck & Company, Inc.|Last Updated: Nov 7, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01432717Study of ACE-536 in Healthy Postmenopausal WomenPHASE1 COMPLETED 40Sep 1, 2011Oct 1, 2012Nov 7, 20121 United States
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Study Endpoints
Primary Endpoints
Number of participants with Adverse Events as a measure of safety and tolerability.
22 weeks
Secondary Endpoints
ACE-536 serum concentration after single and multiple ascending doses.
22 weeks
Hemoglobin levels after single and multiple ascending doses.
22 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ACE-536EXPERIMENTALSubjects assigned to 1 of 5 possible dosing groups.
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
ACE-536BIOLOGICALSubjects receive a total of 2 subcutaneous doses of ACE-536 on Day 1 and Day 15.
PlaceboOTHERSubjects receive a total of 2 subcutaneous doses of placebo on Day 1 and Day 15.
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Eligibility Criteria
Age Range45 Years — 75 Years
SexFEMALE
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Postmenopausal women * Body Mass Index (BMI) of 20 - 32 kg/m2. Key Exclusion Criteria: * History of hypertension * Subject has received any erythropoiesis stimulating agents (e.g., Epogen, Procrit, Aranesp, etc.) within 6 months prior to Day 1 * History of clinically sig...

Countries:United States
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