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LY4515100

Phase 2

Acute Pain | Small molecule | Pain |Eli Lilly and Company|Last Updated: May 1, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment212

FDA Designations

No designations recorded

Clinical trial landscape

LY4515100 · 1 trial · 4 indications

Phase 2 1
NCT07511816A Study of LY4515100 in Participants With Pain Following Third Molar RemovalAcute Pain
RECRUITING212 Analytics
PHASE2RECRUITING
A Study of LY4515100 in Participants With Pain Following Third Molar Removal
Acute PainUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from Baseline in Self-Reported Pain Intensity
Baseline, Up to Day 1

Secondary Endpoints

Time to Reduction in Pain Intensity as Measured by an 11-Item Numerical Scale
Baseline, Up to Day 1
Change in Self-Reported Pain Relief as Measured by 5-Item Categorical Scale
Baseline, Up to Day 1
Time to Rescue Medications
Baseline, Up to Day 1
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
LY4515100EXPERIMENTALAdministered Orally
PlaceboPLACEBO_COMPARATORAdministered Orally

Interventions

NameTypeDescription
LY4515100DRUGAdministered Orally
PlaceboDRUGAdministered Orally
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Eligibility Criteria

Age Range18 Years to 40 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Participant has a body mass index (BMI) between 18.5 and 35.0 kilograms per meter squared (kg/m²) inclusive. * Participant requires extraction of 2 or more third molars, including 2 mandibular molars with partial or full bony impaction, confirmed by panoramic X-ray. Exclusion...

Countries:United States
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Competitive Landscape -Acute Kidney Injury 14 trials (matched to "Acute Pain")

Frequently asked questions about LY4515100

What is LY4515100 used for?

LY4515100 is an investigational small molecule being developed for the treatment of acute pain. It is currently being studied in a Phase 2 clinical trial for pain following third molar removal surgery. The drug is being evaluated for its ability to manage acute pain in this setting.

Who makes LY4515100?

LY4515100 is being developed by Eli Lilly and Company, a pharmaceutical company traded on the New York Stock Exchange under the ticker symbol LLY. The company is conducting clinical research to evaluate the safety and efficacy of this investigational drug for acute pain.

What phase is LY4515100 in?

LY4515100 is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still undergoing clinical trials to assess its safety and effectiveness for treating acute pain following third molar removal.

What clinical trials is LY4515100 in?

LY4515100 is being studied in a Phase 2 clinical trial with the identifier NCT07511816. This randomized, double-blind, placebo-controlled study is evaluating the drug in 212 participants with pain following third molar removal. The trial is currently recruiting participants in the United States.

Is LY4515100 FDA approved?

LY4515100 is not FDA approved. It is an investigational drug currently in Phase 2 clinical development. The drug is being studied in a clinical trial for acute pain following third molar removal, but it has not yet received regulatory approval for any use.