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Influenza vaccine GSK2186877A formulation 1

Phase 1

Influenza | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: Sep 24, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01096056Trial to Evaluate the Safety and the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Healthy ChildrenPHASE1 COMPLETED 40Apr 5, 2010Dec 13, 2010Sep 24, 20181 Spain
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Study Endpoints
Primary Endpoints
Number of Subjects Reporting Fever Grade 2 or Higher
Within 7 days following any vaccination with New generation influenza vaccine GSK2186877A

Fever grade greater than or equal to 2 i.e. ≥ 2 was defined as axillary temperature \>38 degree centigrade (°C).

Secondary Endpoints
Haemagglutination Inhibition (HI) Antibody Titers
At Day 0 and Day 42
The Number of Subjects Seropositive to HI Antibodies
At Day 0 and Day 42
The Number of Subjects Seroprotected to HI Antibodies
At Day 0 and Day 42
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Influenza vaccine GSK2186877A formulation 1 GroupEXPERIMENTALSubjects received 2 doses of influenza vaccine GSK2186877A formulation 1 at Day 0 and Day 21 and 1 dose of Fluarix vaccine at Month 6.
Influenza vaccine GSK2186877A formulation 2 GroupEXPERIMENTALSubjects received 1 dose of influenza vaccine GSK2186877A formulation 2 at Day 0 and 1 dose of Fluarix vaccine at Month 6.
Interventions
NameTypeDescription
Influenza vaccine GSK2186877A formulation 1BIOLOGICALIntramuscular administration, 2 doses
Influenza vaccine GSK2186877A formulation 2BIOLOGICALIntramuscular administration, 1 dose
FluarixBIOLOGICALIntramuscular administration, 1 dose
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Eligibility Criteria
Age Range6 Months — 35 Months
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: All subjects must satisfy ALL the following criteria at study entry: * Subjects who the investigator believes that parent(s)/Legally Acceptable Representative(s) \[LAR(s)\] can and will comply with the requirements of the protocol. * Children, male or female between, and includ...

Countries:Spain
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