Recent Updates
Recently added Catalysts

GSK1562902A

Phase 3

Influenza | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: Aug 20, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment320
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00812981A Study for Evaluation of GSK Biologicals' Pandemic Influenza Vaccine.PHASE3 COMPLETED 320Nov 15, 2008Jun 7, 2009Aug 20, 20181 Taiwan
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Titers for Serum H5N1 Haemagglutination-inhibition (HI) Antibodies
At Day 42

Titers are presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005.

Secondary Endpoints
Titers for Serum H5N1 HI Antibodies
At Day 0 and Day 180
Number of Subjects With H5N1 HI Antibody Concentrations Above the Cut-off Value
At Days 0, 42 and 180
Number of Seroconverted Subjects Against Two Strains of Influenza Disease
At Day 42 and Day 180
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1562902A NP GROUPEXPERIMENTALHealthy male or female adults, between and including 18 to 60 years of age, who received two doses of the new-processed (NP) 1562902A vaccine, administered intramuscularly in the deltoid region of the non-dominant arm, at Days 0 and 21.
1562902A CP GROUPEXPERIMENTALHealthy male or female adults, between and including 18 to 60 years of age, who received two doses of the comparative-processed (CP) 1562902A vaccine, administered intramuscularly in the deltoid region of the non-dominant arm, at Days 0 and 21.
Interventions
NameTypeDescription
GSK1562902ABIOLOGICALnew-processed (NP), administered intramuscularly in the deltoid region of the non-dominant arm
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 59 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Subjects who the investigator believes that they can and will comply with the requirements of the protocol should be enrolled in the study. * A male or female aged 18 to 60 years at the time of the first vaccination. * Written informed consent obtained from the subject. * Good...

Countries:Taiwan
Unlock Eligibility Criteria