Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
GR270773- Phospholipid emulsion · 2 trials · 1 indication
Mortality was assessed by the number of participants who died between days 1 and 28. A summary of death details was given which included whether the participant died between days 1 and 28, whether the death was related sepsis, cause of death, the source of the information, and whether the cause of death was verified by a death record. Participants who had withdrawn from study and all study assessments and for whom survival at day 28 could not be confirmed was treated as deaths for the primary endpoint. The difference in all-cause 28-day mortality rates for each treatment group versus the placebo group in the ITT Population was calculated as placebo - treatment.
| Arm | Type | Description |
|---|---|---|
| Subjects with moderate hepatic impairment | EXPERIMENTAL | Subjects with moderate hepatic impairment as defined by a Child-Pugh score of 7-9 will be included. Subjects will be given GR270773 as a loading infusion of 25 milligram per kilogram per hour (mg/kg/hr) for 2 hours followed by a maintenance infusion of 5 mg/kg/hr for 70 hours. |
| Healthy subjects | EXPERIMENTAL | Subjects will be matched as closely as possible to the group of moderate hepatic subjects for gender, age and body mass index (BMI). Subjects will be administered 25 mg/kg/hr GR270773 as a loading dose for 2 hours followed by a maintenance infusion of 5 mg/kg/hr for 70 hours. Following a washout period of 21 days, the subjects will then receive a loading dose of 75 mg/kg/hr for 2 hours followed by a maintenance dose of 12.5 mg/kg/hr of GR270773 for 70 hours. |
| Name | Type | Description |
|---|---|---|
| Intravenous GR270773- Phospholipid Emulsion | DRUG | - |
| Placebo | OTHER | - |
| Intravenous GR270773 - Phospholipid emulsion | DRUG | GR270773 (lipid emulsion) is a sterile, white to off-white, semi-translucent liquid for intravenous injection. |
Inclusion criteria: * Receiving parenteral antibiotic therapy for a suspected or confirmed Gram-negative infection. * Have at least one new hypoperfusion abnormality or at least one new onset organ failure resulting from the current septic episode. * Must be available and able to receive the first ...
| Company | Ticker | Trials | Lead Phase | Drugs |
|---|---|---|---|---|
| AstraZeneca PLC | AZN | 1 | PHASE2 | AZD4144 |
| ImmunityBio Inc | IBRX | 1 | PHASE2 | Nogapendekin alfa inbakicept |
| Bluejay Diagnostics, Inc. | BJDX | 2 | - | Undisclosed |
| CytoSorbents Corporation | CTSO | 1 | - | Undisclosed |
| Danaher Corporation | DHR | 3 | - | Undisclosed |
| Spectral AI, Inc. Class A | MDAI | 1 | N/A | Undisclosed |
GR270773 is an investigational phospholipid emulsion being studied for the treatment of sepsis, specifically suspected or confirmed gram-negative severe sepsis in adults. It is a small molecule developed by GSK plc. The drug is currently in Phase 2 clinical development and is not approved for use.
GR270773 is being developed by GSK plc, a global biopharmaceutical company listed on the stock exchange under the ticker GSK. The drug is an investigational small molecule in Phase 2 clinical trials for the treatment of sepsis.
GR270773 is in Phase 2 clinical development. It has completed two clinical trials, including a Phase 2 study in patients with suspected or confirmed gram-negative severe sepsis and a Phase 1 study in healthy adults and adults with liver damage. The drug remains investigational.
GR270773 has been studied in two completed clinical trials. The first, NCT00089986, was a Phase 2 study enrolling 1,415 adults with suspected or confirmed gram-negative severe sepsis. The second, NCT00158769, was a Phase 1 study enrolling 16 participants to compare the drug's effects in healthy adults versus those with liver damage.
Yes, GR270773 is a phospholipid emulsion. It is a small molecule drug being investigated for sepsis. The drug has been studied in clinical trials for the treatment of suspected or confirmed gram-negative severe sepsis in adults.