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NeoVax

Phase 1

Kidney Cancer | Small molecule | Oncology |Bristol-Myers Squibb Company|Last Updated: Feb 3, 2026

Success Probability

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Market & Valuation

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Trial Design

CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment19

FDA Designations

No designations recorded

Clinical trial landscape

NeoVax · 1 trial · 1 indication

Phase 1 1
NCT02950766NeoVax Plus Ipilimumab in Renal Cell CarcinomaKidney Cancer
ACTIVE NOT_RECRUITING19 Analytics
PHASE1ACTIVE NOT_RECRUITING
NeoVax Plus Ipilimumab in Renal Cell Carcinoma
Kidney CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with dose-limiting toxicity (DLT) experienced within 49 days (7 weeks) of treatment initiation as assessed by CTCAE v4.0
49 days

Secondary Endpoints

Number of participants with NeoVax induced IFN γ (interferon γ) T-cell Response against neoepitopes measured by ELISPOT at week 16
16 weeks
Number of participants alive at 2 years
2 years
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Neovax in Combination with IpilimumabEXPERIMENTALPatients will undergo surgery with the intent to resect the primary kidney tumor Neovax is a combination of Poly-ICLC and Neoantigen Peptides Priming doses of NeoVax will be administered on days 1, 4, 8, 15, and 22 * In the boost phase, vaccine will be administered on days 78 (week 12) and 134 (week 20 Ipilimumab will be injected within 1 cm of each NeoVax administration
NeoVax aloneEXPERIMENTALPatients will undergo surgery with the intent to resect the primary kidney tumor Neovax is a combination of Poly-ICLC and Neoantigen Peptides Priming doses of NeoVax will be administered on days 1, 4, 8, 15, and 22 * In the boost phase, vaccine will be administered on days 78 (week 12) and 134 (week 20)

Interventions

NameTypeDescription
NeoVaxDRUGcombination of Neoantigen peptides and poly-ICLC
IpilimumabDRUGlocal administration of ipilimumab
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria for Initial Registration: * Ability to understand and the willingness to sign a written informed consent document. * Patients should have suspected stage III or stage IV clear cell renal cell carcinoma (ccRCC), with anticipation that all disease can be surgically resected. Confir...

Countries:United States
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Competitive Landscape -Kidney Cancer 111 trials

Frequently asked questions about NeoVax

What is NeoVax used for in kidney cancer?

NeoVax is an investigational small molecule being studied for the treatment of kidney cancer. It is currently in Phase 1 clinical development. The drug is being evaluated in a clinical trial that combines NeoVax with ipilimumab in patients with renal cell carcinoma.

What does NeoVax target?

NeoVax is a small molecule therapeutic being developed for kidney cancer. The specific molecular target of NeoVax has not been disclosed in the available information. The drug is currently being studied in a Phase 1 clinical trial in combination with ipilimumab for the treatment of renal cell carcinoma.

Who makes NeoVax?

NeoVax is being developed by Bristol-Myers Squibb Company, which trades on the New York Stock Exchange under the ticker symbol BMY. The company is currently conducting a Phase 1 clinical trial of NeoVax in patients with kidney cancer.

What phase is NeoVax in?

NeoVax is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The ongoing Phase 1 trial is studying NeoVax in combination with ipilimumab for the treatment of kidney cancer.

What clinical trials is NeoVax in?

NeoVax is being studied in one active clinical trial with the identifier NCT02950766. This Phase 1 trial, titled 'NeoVax Plus Ipilimumab in Renal Cell Carcinoma,' is enrolling patients with kidney cancer in the United States. The trial is not recruiting new participants and has a target enrollment of 19 patients.

Is NeoVax the same as ipilimumab?

No, NeoVax is not the same as ipilimumab. NeoVax is an investigational small molecule being developed by Bristol-Myers Squibb for kidney cancer. Ipilimumab is a separate drug that is being studied in combination with NeoVax in a Phase 1 clinical trial for the treatment of renal cell carcinoma.