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BMS-986482

Phase 1

Advanced Solid Tumors | Small molecule | Oncology |Bristol-Myers Squibb Company|Last Updated: Feb 3, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment413

FDA Designations

No designations recorded

Clinical trial landscape

BMS-986482 · 1 trial · 1 indication

Phase 1 1
NCT06697197A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid TumorsAdvanced Solid Tumors
RECRUITING413 Analytics
PHASE1RECRUITING
A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors
Advanced Solid TumorsUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with Adverse Events (AEs) as assessed by National Cancer Institute -Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE v5.0)
Up to 135 days post last treatment visit
Number of participants with Serious AEs (SAEs) as assessed by NCI-CTCAE v5.0
Up to 135 days post last treatment visit
Number of participants with AEs meeting protocol-defined Dose-Limiting Toxicity (DLT) criteria as assessed by NCI-CTCAE v5.0
Up to Day 28
Number of participants with AEs leading to discontinuation as assessed by NCI-CTCAE v5.0
Up to 135 days post last treatment visit
Number of deaths as assessed by NCI-CTCAE v5.0
Through study completion (Up to 4 years)

Secondary Endpoints

Concentration at the end of infusion (Cmax)
Up to 135 days post last treatment visit
Time of maximum observed concentration (Tmax)
Up to 135 days post last treatment visit
Area under the concentration-time curve in one dosing interval (AUC(TAU))
Up to 135 days post last treatment visit
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part 1AEXPERIMENTAL -
Part 1B1EXPERIMENTAL -
Part 1B2EXPERIMENTAL -
Part 1B3EXPERIMENTAL -
Part 1CEXPERIMENTAL -
Part 2AEXPERIMENTAL -
Part 2B1EXPERIMENTAL -
Part 2B2EXPERIMENTAL -
Part 2B3EXPERIMENTAL -

Interventions

NameTypeDescription
BMS-986482DRUGSpecified dose on specified days
Nivolumab and rHuPH20DRUGSpecified dose on specified days
Nivolumab/relatlimab/rHuPH20DRUGSpecified dose on specified days
BevacizumabDRUGSpecified dose on specified days
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical...

Countries:United StatesBelgiumDenmarkFranceGreeceItalyNetherlandsSpainSweden
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Competitive Landscape -Other Solid Tumors 9 trials (matched to "Advanced Solid Tumors")

Frequently asked questions about BMS-986482

What is BMS-986482 used for?

BMS-986482 is an investigational small molecule being developed for the treatment of advanced solid tumors. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities. The drug is being studied alone or in combination with other therapies in patients with advanced solid tumors.

Who makes BMS-986482?

BMS-986482 is being developed by Bristol-Myers Squibb Company, which trades on the New York Stock Exchange under the ticker symbol BMY. The company is conducting a Phase 1 clinical trial to evaluate the drug in participants with advanced solid tumors.

What phase is BMS-986482 in?

BMS-986482 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory authority. The ongoing Phase 1 trial is currently recruiting participants with advanced solid tumors.

What clinical trials is BMS-986482 in?

BMS-986482 is being studied in a Phase 1 clinical trial with the identifier NCT06697197. The trial is titled 'A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors' and is currently recruiting. The study is enrolling approximately 413 participants across multiple countries.

Is BMS-986482 the same as any other drug?

BMS-986482 is the primary name for this investigational drug. No alternative names have been identified for this compound. It is being developed by Bristol-Myers Squibb and is currently in Phase 1 clinical trials for advanced solid tumors.