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BL1107

Phase 2

Dry Eye Disease | Small molecule | Ophthalmology |Bausch Health Companies Inc.|Last Updated: Aug 21, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment20

FDA Designations

No designations recorded

Clinical trial landscape

BL1107 · 1 trial · 1 indication

Phase 2 1
NCT07778888BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution TrialDry Eye Disease
NOT YET_RECRUITING20 Analytics
PHASE2NOT YET_RECRUITING
BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial
Dry Eye DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Primary Part 1: Proportion of participants with complete resolution in conjunctival hyperemia at 30 minutes, in each evaluated concentration of BL1107.
Assessed at 30 minutes
Primary Part 2: Proportion of participants with complete resolution in conjunctival hyperemia at 8 hours, in each evaluated concentration of BL1107
Assessed at 8 hours
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BL1107 is sterile ophthalmic solution to be administered at varying concentrationsEXPERIMENTAL -

Interventions

NameTypeDescription
BL1107DRUGBL1107 topical ocular solution
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Documented diagnosis of dry eye disease * Conjunctival hyperemia in both eyes, without clinical signs of infection or allergic conjunctivitis Exclusion Criteria: * Any active ocular disease * Anticipated wearing of contact lenses during study Additional criteria per protoco...

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Competitive Landscape -Dry Eye Disease 7 trials

Recent Changes (Last 90 Days)

LOWAug 21, 2026NCT07778888NEW_TRIAL: changed
LOWAug 21, 2026NCT07778888NEW_TRIAL: changed

Frequently asked questions about BL1107

What is BL1107 used for?

BL1107 is an investigational small molecule being developed for the treatment of Dry Eye Disease. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities. The drug is being studied in a clinical trial to evaluate its effects on hyperemia resolution in patients with dry eye.

Who makes BL1107?

BL1107 is being developed by Bausch Health Companies Inc., a company traded on the New York Stock Exchange under the ticker symbol BHC. The company is conducting clinical research to evaluate the safety and efficacy of this investigational drug for Dry Eye Disease.

What phase is BL1107 in?

BL1107 is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or other regulatory agencies. The drug is being studied in an ongoing clinical trial to assess its potential as a treatment for Dry Eye Disease.

What clinical trials is BL1107 in?

BL1107 is being studied in a Phase 2 clinical trial registered as NCT07778888, titled 'BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial.' This trial is not yet recruiting and plans to enroll 20 participants with Dry Eye Disease. The study is uncontrolled and open-label.

How does BL1107 work?

BL1107 is a small molecule designed to address Dry Eye Disease. While the specific molecular target has not been disclosed, the drug is being investigated for its ability to resolve hyperemia, which is a common symptom of dry eye. The ongoing Phase 2 trial will help determine its mechanism of action.