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BL1107

Phase 2

Dry Eye Disease | Small molecule | Ophthalmology |Bausch Health Companies Inc.|Trials Updated: Aug 21, 2026

BL1107 development status

Highest phase Phase 2
Registered trials 1 across 1 sponsor since Aug 2026

BL1107 target and mechanism

Molecular targetalpha-2B adrenergic receptor
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment20

FDA Designations

No designations recorded

BL1107 clinical trials

BL1107 · 1 trial · 1 indication

Phase 2 1
NCT07778888BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution TrialDry Eye Disease
NOT YET_RECRUITING20 Analytics
PHASE2NOT YET_RECRUITING
BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial
Dry Eye DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Primary Part 1: Proportion of participants with complete resolution in conjunctival hyperemia at 30 minutes, in each evaluated concentration of BL1107.
Assessed at 30 minutes
Primary Part 2: Proportion of participants with complete resolution in conjunctival hyperemia at 8 hours, in each evaluated concentration of BL1107
Assessed at 8 hours
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BL1107 is sterile ophthalmic solution to be administered at varying concentrationsEXPERIMENTAL -

Interventions

NameTypeDescription
BL1107DRUGBL1107 topical ocular solution
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Documented diagnosis of dry eye disease * Conjunctival hyperemia in both eyes, without clinical signs of infection or allergic conjunctivitis Exclusion Criteria: * Any active ocular disease * Anticipated wearing of contact lenses during study Additional criteria per protoco...

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Competitive Landscape -Dry Eye Disease 8 trials

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Recent Changes (Last 90 Days)

LOWAug 21, 2026NCT07778888NEW_TRIAL: changed
LOWAug 21, 2026NCT07778888NEW_TRIAL: changed

Frequently asked questions about BL1107

What is BL1107 used for?

BL1107 is an investigational small molecule being developed for the treatment of Dry Eye Disease. It is currently in Phase 2 clinical development and has not been approved by the FDA. The drug is intended to address symptoms associated with this ophthalmic condition.

What does BL1107 target?

BL1107 targets the alpha-2B adrenergic receptor. By acting on this receptor, the drug is being studied for its potential effects in treating Dry Eye Disease. The specific mechanism of action is under investigation in clinical trials.

Who makes BL1107?

BL1107 is being developed by Bausch Health Companies Inc., which trades under the ticker symbol BHC. The company is conducting clinical research on this investigational drug for Dry Eye Disease.

What phase is BL1107 in?

BL1107 is in Phase 2 clinical development. It is an investigational drug and has not yet received FDA approval. The ongoing Phase 2 trial is designed to evaluate the drug's effects in patients with Dry Eye Disease.

What clinical trials is BL1107 in?

BL1107 is being studied in a Phase 2 clinical trial with the identifier NCT0777888. The trial is titled 'BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial' and is currently not yet recruiting participants. The study plans to enroll 20 patients with Dry Eye Disease.