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OSI-774

Phase 2

Kidney Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Apr 1, 2014

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment63

FDA Designations

No designations recorded

Clinical trial landscape

OSI-774 · 1 trial · 1 indication

Phase 2 1
NCT00193154OSI-774 and Bevacizumab in the Treatment of Patients With Metastatic Renal Cell CarcinomaKidney Cancer
COMPLETED63 Analytics
PHASE2COMPLETED
OSI-774 and Bevacizumab in the Treatment of Patients With Metastatic Renal Cell Carcinoma
Kidney CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Efficacy of the combination of Tarceva and Avastin
18 months

Secondary Endpoints

Objective response rate
18 months
Progression-free survival
18 months
Overall Survival
18 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
OSI-774 & bevacizumabEXPERIMENTALOSI-774 (Tarceva) 150mb PO, days 1-28; bevacizumab (Avastin) 10mg/kg, IV infusion, days 1 and 15; Regimen will be repeated every 28 days.

Interventions

NameTypeDescription
OSI-774DRUG150mg PO, days 1-28, cycle repeated every 28 days
BevacizumabDRUG10mg/kg, IV infusion, Days 1 and 15, 28 day cycles
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: To be included in this study, you must meet the following criteria: * Metastatic or unresectable clear cell kidney cancer confirmed by biopsy * Previous nephrectomy * Maximum of 1 previous regimen for metastatic disease * Ability to perform activities of daily living with minim...

Countries:United States
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Competitive Landscape -Kidney Cancer 111 trials

Frequently asked questions about OSI-774

What is OSI-774 used for in kidney cancer?

OSI-774 is an investigational small molecule being studied for the treatment of kidney cancer, specifically metastatic renal cell carcinoma. It is in Phase 2 clinical development and has been evaluated in a completed clinical trial in the United States.

What does OSI-774 target?

OSI-774 is a small molecule that targets the epidermal growth factor receptor (EGFR). It is being investigated as a potential treatment for kidney cancer, specifically metastatic renal cell carcinoma, and is currently in Phase 2 clinical development.

Who makes OSI-774?

OSI-774 is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker symbol AZN. The drug is currently in Phase 2 clinical development for the treatment of kidney cancer.

What phase is OSI-774 in?

OSI-774 is in Phase 2 clinical development. It is an investigational drug being studied for the treatment of kidney cancer, specifically metastatic renal cell carcinoma. It has completed a Phase 2 clinical trial and is not yet approved by regulatory authorities.

What clinical trials is OSI-774 in?

OSI-774 has been studied in a completed Phase 2 clinical trial with the identifier NCT00193154. This trial evaluated OSI-774 in combination with bevacizumab in patients with metastatic renal cell carcinoma and enrolled 63 participants in the United States.

Is OSI-774 the same as erlotinib?

OSI-774 is also known as erlotinib, a small molecule that targets the epidermal growth factor receptor (EGFR). It is being developed by AstraZeneca PLC and is currently in Phase 2 clinical development for the treatment of kidney cancer.