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AZD2927

Phase 2

Arrhythmia | Small molecule | Cardiovascular |AstraZeneca PLC|Last Updated: Nov 27, 2012

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment20

FDA Designations

No designations recorded

Clinical trial landscape

AZD2927 · 2 trials · 2 indications

Phase 2 1Phase 1 1
NCT01396226A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in PatientsArrhythmia
COMPLETED20 Analytics
PHASE2COMPLETED
A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients
ArrhythmiaUnlock trial analytics

Study Endpoints

Primary Endpoints

Left Atrial Effective Refractory Period
Baseline to last assessment during IP infusion

Change in LAERP from before IP infusion to 1st and 2nd assessments during IP infusion

Safety and tolerability of AZD2927, at screening
Monitoring of Adverse events, Electrocardiograms, vital signs, safety lab and ophtalmologic variables at screening
Safety and tolerability of AZD2927, day 1
Monitoring of Adverse events, Electrocardiograms, vital signs, safety lab and ophtalmologic variables on day 1.
Safety and tolerability of AZD2927, day 2
Monitoring of Adverse events, Electrocardiograms, vital signs and safety lab on day 2.
Safety and tolerability of AZD2927, day 3
Monitoring of Adverse events, Electrocardiograms, vital signs, and safety lab on day 3.
Safety and tolerability of AZD2927, at follow up
Monitoring of Adverse events, Electrocardiograms, vital signs and safety lab at follow up.

Secondary Endpoints

Ventricular Effective Refractory Period
Baseline to last assessment during IP infusion
Paced QT Interval
Baseline to last assessment during IP infusion
Atrio-ventricular Effective Refractory Period
Baseline to last assessment during IP infusion
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
1EXPERIMENTALA single dose of AZD2927 administered as an iv infusion
2PLACEBO_COMPARATORA single dose of placebo administered as an iv infusion

Interventions

NameTypeDescription
AZD2927DRUGA single dose of AZD2927 administered as an iv infusion
PlaceboDRUGA single dose of placebo administered as an iv infusion
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Eligibility Criteria

Age Range20 Years to 80 Years
SexALL
Healthy VolunteersNo
Study Sites5

Inclusion Criteria: * male or postmenopausal female, aged 20 to 80 years inclusive, * clinical indication for catheter ablation of atrial flutter, * history of paroxysmal atrial flutter, with or without paroxysmal AF. Single episodes of persistent atrial flutter or AF requiring cardioversion do not...

Countries:NorwaySweden
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Competitive Landscape -Arrhythmia 12 trials

Frequently asked questions about AZD2927

What is AZD2927 used for?

AZD2927 is an investigational small molecule being studied for cardiovascular conditions, specifically arrhythmia. It has also been evaluated in healthy volunteers to assess its safety and pharmacological effects. The drug is currently in Phase 2 clinical development and is not approved by regulatory authorities.

Who makes AZD2927?

AZD2927 is being developed by AstraZeneca PLC, a multinational pharmaceutical company listed on the stock exchange under the ticker symbol AZN. The company is conducting clinical trials to evaluate the drug's safety and efficacy in cardiovascular indications.

What phase is AZD2927 in?

AZD2927 is in Phase 2 clinical development. It has completed a Phase 1 study in healthy volunteers and a Phase 2 study in patients with arrhythmia. The drug remains investigational and has not received regulatory approval for any indication.

What clinical trials is AZD2927 in?

AZD2927 has been studied in two completed clinical trials. NCT01264250 was a Phase 1 study in healthy male volunteers in Sweden, and NCT01396226 was a Phase 2 study comparing AZD2927 to placebo in patients with arrhythmia in Norway and Sweden.

Is AZD2927 the same as any other drug?

AZD2927 is a unique investigational compound developed by AstraZeneca. No alternative names or brand names have been associated with this drug in clinical development. It is identified solely by its code name AZD2927 in scientific literature and trial registries.