Recent Updates
Recently added Catalysts

AV024

Phase 3

Influenza | Monoclonal antibody | Infectious Disease |AstraZeneca PLC|Last Updated: Nov 20, 2008

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment330
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00240877Study to Evaluate the Safety of a Monovalent Vaccine of a New 6:2 Reassortant in Healthy Adults (AV024)PHASE3 COMPLETED 330Aug 1, 2002Apr 1, 2004Nov 20, 20081 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
- The primary endpoint of this study is fever defined as oral temperature ≥101°F
Days 0-7
Secondary Endpoints
All other reported reactogenicity events and other adverse events.
After 7 days after vaccination
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTALMonovalent vaccine prior to the release of the trivalent vaccine (FluMist).
2PLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
AV024BIOLOGICAL0.5 mL total dose volume administered intranasal by spray applicator (approximately 0.25 mL into each nostril).
PlaceboOTHERPlacebo mist consisting of normal allantoic fluid. 0.5 mL total dose volume administered intranasal by spray applicator (approximately 0.25 mL into each nostril).
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * 18-64 years of age (not yet reached their 65th birthday); * In good health; * Available by telephone; * Ability to understand and comply with the requirements of the protocol; and * Signed informed consent. Exclusion Criteria: * Any condition, other than age, for which the i...

Countries:United States
Unlock Eligibility Criteria