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Alnylam Pharmaceuticals, Inc.

ALNYFDA catalysts, PDUFA dates & pipeline intelligence
$227.66
▲ +3.63 · +1.62%

Financials

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52W LOW $197.8152W HIGH $485.36
Volume
1.44 M
Value Traded
305.53 M
Short % Float
5.78%
Days to Cover
6.5
-2.41%Week
-10.85%1 Month
-18.23%3 Month
-26.21%6 Month
+110.45%5 Year
+4,776.23%All Time

Cash Data

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Key Stats

Market Cap
30.46 B
EPS (TTM)
6.04
P/E Ratio
37.70
Ent. Value
27.24 B
Total Shares
133.74 M
Float Shares
133.38 M
Insiders
0.32%
Institutions
100.61%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 1b data presentation
Brezosiran (ALN-HTT02)
Huntington's disease
Phase 1bRNA-Based TherapiesNervous System
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

ALNY Catalyst Timeline

Dated clinical, regulatory and corporate events for Alnylam Pharmaceuticals, Inc.

Catalyst Timeline

Dated clinical, regulatory & corporate events for Alnylam Pharmaceuticals, Inc.

817Total events
21Upcoming
307Tier-1 (high impact)
2014 to 2027Coverage

Upcoming catalysts 2

T1Topline Readout
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ALN-6400
T1Topline Readout
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ALN-HTT02

Event history 50

▲Topline ReadoutbrezosiranClinical Data
Positive initial Phase 1b data for brezosiran (ALN-HTT02) showing 60-64% mean CSF mHTT reduction at month 3
Huntington's diseasesource ↗
◆Oral PresentationVutrisiranApprovedPresentation
Cardiac Presentation and Treatment Response by Sex in Patients with Transthyretin Amyloidosis
▲Oral PresentationVutrisiranApprovedPresentation
Alnylam presents new data on AMVUTTRA at ESC Congress 2026
Transthyretin-Amyloidose (ATTR)source ↗
▲Oral PresentationVutrisiranApprovedPresentation
Late-breaking oral presentation of HELIOS-B prespecified subgroup analysis by baseline tafamidis use at ESC Congress 2026
ATTR-CMsource ↗
▲Poster PresentationVutrisiranApprovedPresentation
Pooled analysis across four Phase 3 studies of vutrisiran and patisiran presented at ESC Congress 2026
ATTR-CMsource ↗
▲Oral PresentationZilebesiranPresentation
Oral presentation of KARDIA-3 subgroup analysis at ESC Congress 2026
uncontrolled hypertensionsource ↗
▲PublicationVutrisiranApprovedPresentation
HELIOS-B subgroup analysis simultaneously published in Journal of the American College of Cardiology
ATTR-CMsource ↗
▲Poster PresentationZilebesiranPresentation
New subgroup analysis from KARDIA-3 Phase 2 study of zilebesiran presented at ESC Congress 2026
uncontrolled hypertensionsource ↗
▲Subgroup AnalysisVutrisiranApprovedClinical Data
Post hoc HELIOS-B analysis shows 25% less decline in intrinsic capacity and 52% reduction in risk of decline with vutrisiran
ATTR-CMsource ↗
▲Safety Data UpdateVutrisiranApprovedClinical Data
Post hoc HELIOS-B safety analysis shows fewer adverse events with vutrisiran versus placebo across populations
ATTR-CMsource ↗
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Past FDA Catalysts and PDUFA Decisions

How ALNY actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2025-12-31Mivelsiran Phase 1 interim results Phase 1
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
14
Drugs Scored
rNPV / MCap
Top Drug
Top 4%
Mid Cap
(rank 27 of 657)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Jun 2026; product lines: last four quarters to Jun 2026 (10-K and 10-Q))
ProductRevenuePrior periodChange
Amvuttra
GIVLAARI
OXLUMO
ONPATTRO
Showing 36 of 50 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
ALN-4324 Small moleculeNCT06845202Type 2 Diabetes Mellitus (T2DM)Phase 2 ACTIVE NOT_RECRUITING 129Aug 31, 2027
Nucresiran RNA therapyNCT07223203Hereditary Transthyretin-Mediated Amyloidosis With PolyneuropathyPhase 3 RECRUITING 125Jun 12, 2031
Nucresiran RNA therapyNCT07052903Transthyretin Amyloidosis With CardiomyopathyPhase 3 RECRUITING 1,750Nov 30, 2032
Zilebesiran RNA therapyNCT07181109High Risk Cardiovascular DiseasePhase 3 RECRUITING 11,000Sep 23, 2030
ALN-2232 Small moleculeNCT07463846ObesityPhase 1 RECRUITING 156Apr 28, 2028
ALN-6222 Small moleculeNCT07624071ObesityPhase 1 RECRUITING 88Dec 14, 2027
Mivelsiran RNA therapyNCT07636811Down Syndrome-Associated Alzheimer's Disease (DS-AD)Phase 2 RECRUITING 58Jul 30, 2031
ALN-APP RNA therapyNCT06393712Cerebral Amyloid AngiopathyPhase 2 ACTIVE NOT_RECRUITING 210Dec 14, 2029
ALN-APP RNA therapyNCT05231785Early-Onset Alzheimer DiseasePhase 1 RECRUITING 60Jan 11, 2029
ALN-AGT01 RVR Small moleculeNCT07553442HypertensionPhase 2 RECRUITING 93Oct 1, 2028
ALN-6400 Small moleculeNCT07575308Von Willebrand Disease (VWD)Phase 2 RECRUITING 24Nov 29, 2028
ALN-6400 Small moleculeNCT06659640Hereditary Hemorrhagic TelangiectasiaPhase 1 ACTIVE NOT_RECRUITING 89Jun 22, 2028
ALN-5288 Small moleculeNCT07214727Alzheimer's DiseasePhase 1 RECRUITING 50Mar 6, 2030
ALN-4285 Small moleculeNCT07295717UndisclosedPhase 1 RECRUITING 76Mar 23, 2027
ALN-4915 Small moleculeNCT07535606UndisclosedPhase 1 ACTIVE NOT_RECRUITING 36Jul 31, 2027
ALN-BCAT Small moleculeNCT06600321Advanced Hepatocellular CarcinomaPhase 1 RECRUITING 158Oct 31, 2027
ALN-HTT02 Small moleculeNCT06585449Huntington's DiseasePhase 1 RECRUITING 66Jul 5, 2028
Vutrisiran RNA therapyMarketedNCT04153149Transthyretin Amyloidosis (ATTR) With CardiomyopathyPhase 3 ACTIVE NOT_RECRUITING 1,355Dec 2, 2026
Zilebesiran RNA therapyCompletedNCT06272487High Cardiovascular RiskPhase 2 COMPLETED 375Dec 1, 2025
ALN-AGT01 RNA therapyCompletedNCT03934307HypertensionPhase 2 COMPLETED 518Jan 4, 2023
Zilebesiran RNA therapyCompletedNCT06423352Mild to Moderate HypertensionPhase 1 COMPLETED 36Jul 17, 2025
Indapamide Small moleculeCompletedNCT05103332HypertensionPhase 2 COMPLETED 663Sep 13, 2024
patisiran RNA therapyMarketedNCT03759379Amyloidosis, HereditaryPhase 3 COMPLETED 164Nov 5, 2025
patisiran RNA therapyMarketedNCT03862807Amyloidosis, FamilialPhase 3 COMPLETED 24Oct 20, 2020
patisiran RNA therapyMarketedNCT01617967TTR-mediated AmyloidosisPhase 3 COMPLETED 254Jan 1, 2014
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PTRS, rNPV, enrollment velocity, trial design quality and ML risk signals for every asset above.
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Clinical Trial Results

Readouts, endpoints and source filings for every ALNY program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
brezosiran Huntington's diseasePhase 1b2026-10-23significant huntingtin loweringRead MoreAlnylam Announces Positive Initial Phase 1b Data for Brezosiran (ALN-HTT02) Demonstrating Deep and Durable Huntingtin Lowering in Huntington’s DiseaseRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
SUPRAN BRYANOfficer (EVP, CLO and Secretary)Sell -1,758 12,807 held$226.88 10/02/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
Deep Track Capital, LP 3.6 % 248.35 M 825.00 K 65% ( 325.00 K)
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Shares held by hedge funds each quarter, and who bought or sold.

ALNY Institutional Ownership Trends

ALNY Short Interest

Shares sold short, counted twice a month.

5.78%
Short % of Float
of tradable shares sold short
7.7M
Shares Sold Short
+7.2% vs prior count
6.5 High
Days to Cover
trading days of normal volume to buy every short share back
1.2M
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-11-20
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

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Competitive positioning

How ALNY ranks across every disease it competes in

Competitive Position is a premium feature
See how ALNY ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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ALNY News

ALNY
Oct 23, 2026
ALNYPhases
▲ +1.6%today

Alnylam Announces Positive Initial Phase 1b Data for Brezosiran (ALN-HTT02) Demonstrating Deep and Durable Huntingtin Lowering in Huntington’s Disease

Alnylam Pharmaceuticals announced positive initial Phase 1b data for brezosiran, showing a mean reduction of mutant huntingtin protein by 60-64% at month 3. The study demonstrated individual reductions of up to 83% with a favorable safety profile. A pivotal study is planned for 2027, pending regulatory alignment.

Read more →
ALNY
Oct 15, 2026
ALNYConferences/Events

Alnylam to Webcast Conference Call Discussing Third Quarter 2026 Financial Results

Alnylam Pharmaceuticals will report its third quarter 2026 financial results on October 29, 2026. The management will discuss the results and future expectations during a conference call at 8:30 am ET. A live audio webcast will be available on their website, with an archived version accessible shortly after the event.

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ALNY
Sep 29, 2026
ALNYGeneral

AMVUTTRA® (vutrisiran) ‘Play by Play’ Initiative Highlights Former Athletes’ Stories to Shine a Light on the Often-Missed Signs of ATTR-CM

Alnylam Pharmaceuticals has launched the AMVUTTRA® (vutrisiran) ‘Play by Play’ initiative, aimed at educating the public about transthyretin-mediated amyloidosis (ATTR-CM). This initiative features stories from former professional athletes and their care teams to highlight the often-missed signs of the condition. The goal is to promote early recognition of symptoms for better patient care.

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ALNY
Sep 2, 2026
ALNYConferences/Events
▲ +8.7%on this news

Alnylam to Webcast Presentations at Upcoming September Investor Conferences

Alnylam Pharmaceuticals has announced that its management will present company overviews at two upcoming investor conferences. The Wells Fargo 21st Annual Healthcare Conference is scheduled for September 8, 2026, and the Morgan Stanley 24th Annual Global Healthcare Conference will take place on September 14, 2026. Both events will feature live audio webcasts.

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ALNY
Aug 30, 2026
ALNYConferences/Events

Alnylam Presents New Data at ESC Congress 2026 Reinforcing Strength in RNAi-Powered TTR Silencing Across ATTR-CM Patient Populations and Treatment Settings

Alnylam Pharmaceuticals presented new data at the ESC Congress 2026, highlighting the effectiveness of RNAi-powered silencing in treating cardiovascular diseases. The results strengthen the clinical profile of AMVUTTRA® (vutrisiran) in various patient populations and treatment settings for transthyretin amyloidosis (ATTR). This reinforces the drug's potential across different manifestations of the disease.

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ALNY
Aug 24, 2026
ALNYConferences/Events

Alnylam to Present New Data Reinforcing Strength in RNAi-Powered TTR Silencing and Continued Progress in Hypertension at ESC Congress 2026

Alnylam Pharmaceuticals will present new clinical and real-world data at the ESC Congress 2026. The data will focus on their transthyretin-mediated amyloidosis (ATTR) and hypertension programs. This presentation aims to reinforce the efficacy of their RNAi-powered therapies. The congress is scheduled for August 28-31, 2026, in Munich, Germany.

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ALNY
Jul 30, 2026
ALNYGeneral
▼ -28.3%on this news

Alnylam Pharmaceuticals Reports Second Quarter 2026 Financial Results and Highlights Recent Period Progress

Alnylam Pharmaceuticals reported significant financial results for Q2 2026, highlighting a historic achievement of over $1 billion in quarterly product revenues. The company emphasized its ongoing advancements in the RNAi therapeutics sector and expressed optimism about future growth. This performance marks a pivotal moment in Alnylam's business trajectory.

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ALNY
Jul 16, 2026
ALNYConferences/Events

Alnylam to Webcast Conference Call Discussing Second Quarter 2026 Financial Results

Alnylam Pharmaceuticals will report its second quarter 2026 financial results on July 30, 2026, before market opening. The management team will discuss these results and provide future expectations during a conference call scheduled for 8:30 am ET on the same day. This event highlights the company's ongoing commitment to transparency and stakeholder engagement.

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ALNY
Jul 15, 2026
ALNYConferences/Events

Alnylam Highlights Progress with Neuroscience Programs at AAIC 2026, Showcasing Potential of RNAi in Neurological Disease

Alnylam Pharmaceuticals presented significant advancements in its neuroscience programs at the AAIC 2026. The company emphasized the potential of RNA interference (RNAi) therapeutics to meet the needs of patients suffering from neurological diseases. Notably, the investigational therapeutic Mivelsiran targets amyloid precursor protein, which could have implications for treatment.

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ALNY
Jun 25, 2026
ALNYGeneral

Komodo Expands Strategic Partnership With Alnylam to Scale AI-Powered Intelligence Platform

Komodo has expanded its strategic partnership with Alnylam Pharmaceuticals to enhance its AI-powered intelligence platform. This collaboration aims to leverage advanced analytics to improve healthcare outcomes. The details of the expansion and its implications for both companies were not specified in the article.

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ALNY
Jun 12, 2026
ALNYConferences/Events

Alnylam to Host Tenth “RNAi Roundtable” Webcast Series

Alnylam Pharmaceuticals is set to host the tenth installment of its 'RNAi Roundtable' webcast series. This event aims to engage stakeholders in discussions about RNA interference technology and its applications. Further details about the webcast, including speakers and topics, have not been provided in the article.

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ALNY
Jun 10, 2026
ALNYGeneral

GENESIS Pharma Expands Strategic Commercial Partnership with Alnylam Pharmaceuticals for RNAi Therapeutics to the Nordic Region

GENESIS Pharma has expanded its strategic partnership with Alnylam Pharmaceuticals to enhance the commercialization of RNAi therapeutics in the Nordic region. This collaboration aims to leverage both companies' strengths to improve patient access to innovative treatments. The partnership reflects a commitment to advancing RNAi technology in new markets.

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ALNY
Jun 3, 2026
ALNYGeneral

Alnylam and Inceptive Form Strategic AI Collaboration to Accelerate the Discovery of RNAi Therapeutics

Alnylam Pharmaceuticals has announced a strategic collaboration with Inceptive to leverage artificial intelligence in the discovery of RNA interference (RNAi) therapeutics. This partnership is expected to enhance the efficiency and effectiveness of developing new RNAi-based treatments. The collaboration highlights the growing trend of integrating AI in biopharmaceutical research.

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ALNY
May 19, 2026
ALNYGeneral

Alnylam Issues 2025 Corporate Responsibility Report

Alnylam Pharmaceuticals has released its 2025 Corporate Responsibility Report. The report outlines the company's commitment to sustainability and ethical practices. However, specific details regarding the content of the report are not provided in the article.

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ALNY
May 12, 2026
ALNYConferences/Events

New Data Analyses Presented at Heart Failure 2026 Demonstrate Robust and Consistent Clinical Benefit of Vutrisiran as a First-Line Treatment Option Across ATTR-CM Patient Populations, Including Patients with a High Disease Burden

The article discusses new data analyses presented at Heart Failure 2026 regarding Vutrisiran as a first-line treatment for ATTR-CM patients. The findings suggest that Vutrisiran offers robust and consistent clinical benefits across diverse patient populations, including those with a high disease burden. However, specific details about the data or outcomes are not provided.

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ALNY
May 7, 2026
ALNYConferences/Events

Alnylam to Webcast Presentations at Upcoming Investor Conferences

Alnylam Pharmaceuticals will present company overviews at two upcoming investor conferences: the BofA Securities Healthcare Conference on May 13, 2026, and the Goldman Sachs Annual Healthcare Conference on June 9, 2026. Live audio webcasts of the presentations will be available on the company's website, with replays accessible within 48 hours post-event.

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ALNY
May 4, 2026
ALNYConferences/Events

Alnylam to Present New Analyses at Heart Failure 2026 Underscoring Consistent Clinical Profile of Vutrisiran in ATTR-CM

Alnylam Pharmaceuticals is set to present new analyses at the Heart Failure 2026 conference. The focus will be on the consistent clinical profile of Vutrisiran in treating ATTR-CM. This presentation aims to highlight the drug's effectiveness and reliability in managing heart failure associated with this condition.

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ALNY
Apr 30, 2026
ALNYGeneral

Alnylam Pharmaceuticals Reports First Quarter 2026 Financial Results and Highlights Recent Period Progress

Alnylam Pharmaceuticals reported strong financial results for Q1 2026, achieving over $1 billion in product revenues. The company is advancing its RNAi therapeutics pipeline, including three Phase 3 trials and a new Phase 1 study for obesity. Notably, the TRITON-CM study of nucresiran is expanding enrollment due to faster-than-expected patient recruitment.

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ALNY
Apr 16, 2026
ALNYConferences/Events

Alnylam to Webcast Conference Call Discussing First Quarter 2026 Financial Results

Alnylam Pharmaceuticals has announced a conference call to discuss its financial results for the first quarter of 2026. The call will provide insights into the company's performance and future outlook. Details regarding the timing and access to the webcast will be provided closer to the date.

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ALNY
Mar 30, 2026
ALNYConferences/Events

New Data Presented at ACC.26 Further Support Benefits of Vutrisiran in ATTR-CM and Potential of Zilebesiran for Hypertension Management

The article mentions new data presented at ACC.26 regarding Vutrisiran's benefits in treating ATTR-CM and highlights Zilebesiran's potential for hypertension management. However, specific details about the data or outcomes are not provided.

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About Alnylam Pharmaceuticals, Inc.

Cambridge, MA 2,500 employees alnylam.com
Headquarters675 WEST KENDALL STREET, CAMBRIDGE, MA, 02142
Founded2002
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