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ALN-4915

Phase 1

Healthy Volunteers | Small molecule | Other |Alnylam Pharmaceuticals, Inc.|Last Updated: Aug 12, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment44

FDA Designations

No designations recorded

Clinical trial landscape

ALN-4915 · 1 trial · 1 indication

Phase 1 1
NCT07535606A Study to Evaluate ALN-4915 in Adult Healthy VolunteersHealthy Volunteers
RECRUITING44 Analytics
PHASE1RECRUITING
A Study to Evaluate ALN-4915 in Adult Healthy Volunteers
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Study Endpoints

Primary Endpoints

Frequency of Adverse Events
Serious adverse events (SAEs) after signing of ICF up to Month 12; nonserious AEs after first dose of study drug up to Month 12

Secondary Endpoints

Change from Baseline Inflammatory Markers in Plasma
Baseline up to Month 9
Concentration of ALN-4915 in Plasma
Predose up to Day 3
Concentration of ALN-4915 in Urine
Predose up to Day 1
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ALN-4915EXPERIMENTALParticipants will be administered a single dose of ALN-4195.
PlaceboPLACEBO_COMPARATORParticipants will be administered a single dose of placebo.

Interventions

NameTypeDescription
ALN-4915DRUGALN-4915 will be administered subcutaneously (SC)
PlaceboDRUGPlacebo will be administered SC
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Is willing and able to complete all study assessments Exclusion Criteria: * Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>upper limit of normal (ULN) * Has total bilirubin \>ULN * Has no history of invasive infection by an encapsulated organism * H...

Countries:United Kingdom
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Recent Changes (Last 90 Days)

LOWAug 12, 2026NCT07535606lastUpdatePostDate: changed
LOWAug 12, 2026NCT07535606lastUpdatePostDate: changed
LOWJul 24, 2026NCT07535606lastUpdatePostDate: changed
LOWJul 24, 2026NCT07535606lastUpdatePostDate: changed
LOWJun 12, 2026NCT07535606lastUpdatePostDate: changed
LOWJun 12, 2026NCT07535606lastUpdatePostDate: changed

Frequently asked questions about ALN-4915

What is ALN-4915 used for?

ALN-4915 is an investigational drug being studied in adult healthy volunteers. It is currently in Phase 1 clinical development, with an ongoing trial evaluating its safety and tolerability in this population. The drug is being developed by Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY).

Who makes ALN-4915?

ALN-4915 is being developed by Alnylam Pharmaceuticals, Inc., a biopharmaceutical company traded on NASDAQ under the ticker ALNY. The company is currently conducting a Phase 1 clinical trial of ALN-4915 in healthy volunteers.

What phase is ALN-4915 in?

ALN-4915 is in Phase 1 clinical development. The drug is investigational and has not been approved by regulatory authorities. A Phase 1 study is currently recruiting participants to evaluate the drug in adult healthy volunteers.

What clinical trials is ALN-4915 in?

ALN-4915 is being evaluated in a Phase 1 clinical trial with the identifier NCT07535606, titled "A Study to Evaluate ALN-4915 in Adult Healthy Volunteers." This randomized, double-blind, placebo-controlled study is recruiting 44 participants in the United Kingdom.

Is ALN-4915 the same as any other drug?

No alternative names for ALN-4915 have been disclosed. The drug is identified solely by its development code ALN-4915 in the ongoing clinical trial. It is an investigational compound being studied by Alnylam Pharmaceuticals.