Recent Updates
Recently added Catalysts

memantine

Phase 3

Open-Angle Glaucoma | Small molecule | Ophthalmology |AbbVie Inc.|Last Updated: Nov 4, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindUNCONTROLLED
Total Trials2
Total Enrollment2,298
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00168350Memantine in Patients With Chronic GlaucomaPHASE3 COMPLETED 1,179Mar 1, 2000Sep 1, 2006Nov 4, 2010 -
NCT00141882Memantine in Patients With Chronic GlaucomaPHASE3 COMPLETED 1,119Mar 1, 1999Aug 1, 2006Nov 4, 2010 -
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Progression of glaucoma
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
memantineDRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 82 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * glaucoma damage on examination of visual field and optic disc * good visual acuity (with glasses if needed)

Unlock Eligibility Criteria
Competitive Landscape -Open-Angle Glaucoma 9 trials