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Ethinyl Estradiol+ Levonorgestrel

Phase 1

Healthy Volunteer | Small molecule | Other |AbbVie Inc.|Last Updated: Jul 30, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment15

FDA Designations

No designations recorded

Clinical trial landscape

Ethinyl Estradiol+ Levonorgestrel · 1 trial · 1 indication

Phase 1 1
NCT07502417A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female ParticipantsHealthy Volunteer
COMPLETED15 Analytics
PHASE1COMPLETED
A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female Participants
Healthy VolunteerUnlock trial analytics

Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

Cmax of Ethinyl Estradiol and Levonorgestrel.

Time to Cmax (Tmax) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

Tmax of Ethinyl Estradiol and Levonorgestrel.

Terminal Phase Elimination Rate Constant (β) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

β of Ethinyl Estradiol and Levonorgestrel.

Terminal Phase Elimination Half-Life (t1/2) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

t1/2 of Ethinyl Estradiol and Levonorgestrel.

Area Under the Plasma Concentration-Time Curve From Time 0 to Time of Last Measurable Concentration (AUCt) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

AUCt of Ethinyl Estradiol and Levonorgestrel.

Area Under the Plasma Concentration-Time Curve From Time 0 to Infinite Time (AUCinf) of Ethinyl Estradiol and Levonorgestrel
Up to Day 5 in Period 1 and between Days 14-21 in Period 2

AUCinf of Ethinyl Estradiol and Levonorgestrel.

Number of Participants with Adverse Events (AEs)
Up to Approximately 82 Days

An AE is defined as any untoward medical occurrence in a patient or clinical investigation in which a participant is administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.

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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Period 1 & 2EXPERIMENTALIn Period 1, participants will receive a single dose of ethinyl estradiol and levonorgestrel. In Period 2, participants will receive multiple daily doses of ABBV-722 and a single dose of ethinyl estradiol and levonorgestrel.

Interventions

NameTypeDescription
Ethinyl Estradiol + LevonorgestrelDRUGOral
ABBV-722DRUGOral
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Eligibility Criteria

Age Range18 Years to 65 Years
SexFEMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Laboratory values meet the criteria specified in the protocol. * A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile, and a 12-lead electrocardiogram (ECG). Exclusion Criteria: * History of an...

Countries:United States
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Recent Changes (Last 90 Days)

MEDIUMAug 30, 2026NCT07502417TRIAL_REMOVED: changed
MEDIUMAug 30, 2026NCT07502417TRIAL_REMOVED: changed
MEDIUMAug 30, 2026NCT07502417TRIAL_REMOVED: changed
HIGHJul 30, 2026NCT07502417Status: ACTIVE_NOT_RECRUITING → COMPLETED
HIGHJul 30, 2026NCT07502417Status: ACTIVE_NOT_RECRUITING → COMPLETED
MEDIUMJun 16, 2026NCT07502417Status: RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJun 16, 2026NCT07502417Status: RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJun 16, 2026NCT07502417Status: RECRUITING → ACTIVE_NOT_RECRUITING

Frequently asked questions about Ethinyl Estradiol+ Levonorgestrel

What is Ethinyl Estradiol + Levonorgestrel used for?

Ethinyl Estradiol + Levonorgestrel is a combination of two hormones used in a Phase 1 clinical trial to assess its drug levels in healthy adult female participants. The study, NCT07502417, was conducted in the United States and has been completed. It is an investigational drug combination being studied for research purposes.

Who makes Ethinyl Estradiol + Levonorgestrel?

Ethinyl Estradiol + Levonorgestrel is being developed by AbbVie Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker ABBV. The company conducted a Phase 1 clinical trial to evaluate the effect of another drug, ABBV-722, on the levels of ethinyl estradiol and levonorgestrel in healthy female participants.

What phase is Ethinyl Estradiol + Levonorgestrel in?

Ethinyl Estradiol + Levonorgestrel is in Phase 1 clinical development. The single trial listed, NCT07502417, is a Phase 1 study that has been completed. It is an investigational combination and is not approved by regulatory authorities for any indication.

What clinical trials is Ethinyl Estradiol + Levonorgestrel in?

Ethinyl Estradiol + Levonorgestrel has one completed clinical trial, NCT07502417, titled "A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female Participants." The study enrolled 15 healthy female participants aged 18 years and older in the United States.

Is Ethinyl Estradiol + Levonorgestrel the same as ethinyl estradiol/levonorgestrel?

Yes, Ethinyl Estradiol + Levonorgestrel is the same as ethinyl estradiol/levonorgestrel. These are alternative names for the same combination of hormones. The drug is being studied in a Phase 1 clinical trial by AbbVie Inc. to assess its levels in healthy adult female participants.