3710 - 33rd Street NW, Calgary, Alberta, Canada T2L

3710 - 33rd Street NW, Calgary, Alberta, Canada T2L

T + 1 403 455 7727 | xortx.com | TSXV / NASDAQ : XRTX

NOTICE OF ANNUAL & SPECIAL MEETING OF SHAREHOLDERS

NOTICE IS HEREBY GIVEN that the annual and special meeting (the "Meeting")

of the shareholders (the "Shareholders") of XORTX Therapeutics Inc. (the "Company") will be held at

3710 - 33rd Street NW, Calgary, Alberta, Canada T2L 2M1 at 10:00 a.m. (Calgary time), on Tuesday, March 24, 2026.

The Meeting is being called for the following purposes:

Particulars of the foregoing matters are described in further detail in the management information circular.

Only Shareholders of record at the close of business on February 20, 2026 (the

"Record Date") are entitled to notice of and to attend the Meeting or any adjournment or adjournments thereof and to

vote thereat, unless, after the Record Date: (i) a new shareholder; or (ii) a holder of record transfers his, her or its common shares

in the capital of the Company ("Common Shares") to a transferee, and the new shareholder or the transferee (as the case

may be), upon producing properly endorsed share certificates or otherwise establishing that he, she or it owns such Common Shares, requests,

not later than two business days before the Meeting, that the new shareholder's or transferee's name (as the case may be)

be included in the list of shareholders entitled to vote such Common Shares, in which case such new shareholder or transferee shall be

entitled to vote such Common Shares, as the case may be, at the Meeting.

DATED at Calgary, Alberta this 25th day of February, 2026.

A Shareholder may attend the Meeting in person

or may be represented by proxy. Shareholders are requested to complete, date, sign and return the accompanying form of proxy for use

at the Meeting or any adjournments or postponements thereof. To be effective, the enclosed form of proxy must be mailed, hand delivered,

faxed or voted online or by telephone so as to reach or be deposited with TSX Trust Company at 100 Adelaide Street West, Suite 301, Toronto,

Ontario, Canada, M5H 4H1, not later than two business days (excluding Saturdays, Sundays and statutory holidays in the City of Toronto,

Ontario) prior to the time set for the Meeting or any adjournments or postponements thereof.