Full Press Release Details
FOR RELEASE SEPTEMBER
10, 2007 at 7:30 a.m. ET
TECHNOLOGIES ANNOUNCES REACQUISITION OF FULL RIGHTS TO BREMELANOTIDE PROGRAM
CRANBURY, N.J. September 10,
2007 Palatin Technologies, Inc. (AMEX: PTN) today announced it has reacquired full
rights to bremelanotide, a first in class melanocortin agonist drug candidate for the
treatment of male erectile dysfunction (ED) and female sexual dysfunction (FSD) from King
Pharmaceuticals Inc. (NYSE: KG).
The companies mutually agreed to end
their collaborative development and marketing agreement on bremelanotide, with King
exercising its right to terminate. Under the termination, Palatin has all rights to
bremelanotide, without any obligation for future payments to King. King has no financial
obligation for future payments to Palatin, other than for previously incurred costs not
yet reimbursed and approved expense reimbursements related to the wind-down of the
collaboration. The decision follows recent responses from representatives of the U.S. Food
and Drug Administration (FDA), which raised serious concerns about the acceptable
benefit/risk ratio to support the progression of bremelanotide into Phase 3 studies for ED
as a first-line therapy in the general population.
The termination of the collaborative
development and marketing agreement is effective December 6, 2007. King retains the
previously issued Palatin unregistered common stock and warrants.
Palatin is in the process of
reviewing the responses and comments made by the FDA and plans to engage the FDA in
further discussions in order to determine next steps related to the further development of
bremelanotide for the treatment of ED.
Regarding the FSD program with
bremelanotide, we have completed an exploratory at-home Phase 2 clinical trial in pre- and
postmenopausal women and are in the final stages of compiling the data. We anticipate
releasing the results later this month, stated Carl Spana, Ph.D., President and
Chief Executive Officer of Palatin.
Palatin will also continue to focus
its efforts on the Company s pipeline of preclinical therapeutics, including its
compounds for obesity partnered with AstraZeneca and a lead clinical candidate for the
treatment of congestive heart failure.
Webcast Access Information
Palatin Technologies management
will discuss the status of the bremelanotide program during a conference call and webcast
today at 9:00 a.m. ET.
| Conference Call Live | 9/10/2007 at 9:00 a.m. ET | |
| Domestic Dial-In Number | 1-888-802-2225 | |
| International Dial-In Number | 1-913-312-1268 | |
| Conference Call Replay | 9/10/2007 - 9/17/2007 | |
| Domestic Dial-In Number | 1-888-203-1112 | |
| International Dial-In Number | 1-719-457-0820 | |
| Replay Passcode # | 6090184 |
The webcast and replay can be
accessed by logging on to the Investor Center-Webcasts section of
Palatin s website at www.palatin.com.
as the consistent inability to attain and maintain an erection sufficient for sexual
intercourse. The condition is correlated with increasing age, cardiovascular disease,
hypertension, diabetes, hyperlipidemia, and smoking. In addition, certain prescription
drugs and psychogenic issues may contribute to ED. It is estimated that some degree of ED
affects one half of all men over the age of 40 and that 150 million men worldwide suffer
disorder is defined by the American Foundation for Urologic Disease as: The
persistent or recurrent inability to attain or maintain sufficient sexual excitement,
causing personal distress. It may be expressed as a lack of subjective excitement or a
lack of genital or other somatic responses. FSD consists of four components,
hypoactive sexual desire disorder, female sexual arousal disorder (FSAD), dyspareunia or
painful intercourse and anorgasmia. To establish a diagnosis of FSD, these components
must be associated with personal distress, as determined by the affected woman. A
February 10, 1999 study published in the Journal of the American Medical Association,
JAMA, titled, Sexual Dysfunction in the United States: Prevalence and Predictors, states
that some form of FSD appears to be prevalent in approximately 43 percent of the female
About Palatin Technologies,
Inc.Palatin Technologies, Inc. is a biopharmaceutical company focused on
discovering and developing targeted, receptor-specific small molecule and peptide
therapeutics. The Company s internal research and development capabilities, anchored
by its proprietary MIDAS technology, are fueling product development. Palatin s
strategy is to develop products and then form marketing collaborations with industry
leaders in order to maximize their commercial potential. The Company currently has
AstraZeneca and Tyco Healthcare
Mallinckrodt. For additional information regarding Palatin, please visit Palatin
Technologies website at http://www.palatin.com.
| Contacts: For Palatin Technologies: | For Institutional Investors and Media: |
| Stephen T. Wills, CPA, MST | Carney Noensie |
| EVP-Operations / Chief Financial Officer | Burns McClellan |
| (609) 495-2200 | (212) 213-0006 |
| info@palatin.com | cnoensie@burnsmc.com |