Full Press Release Details
BOSTON, April 17, 2023 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ: PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced the following upcoming ulixacaltamide presentations and events focused on Essential Tremor (ET):
Medical Conference Presentations
75th Annual American Academy of Neurology (AAN), Boston, MA Summary: Industry talk presenting Essential1 topline results
Title: Ulixacaltamide Essential1 ET Topline Results
Date/Time: Sunday, April 23, 2023 at 1:00 p.m. EDT (Emerging Neurologic Care Presentation Stage in the Exhibit Hall)
World Congress on Parkinson’s Disease and Related Disorders 2023 (IAPRD), Chicago, IL Summary: Poster presenting Essential1 topline results
Title: Essential1: Results from a Phase 2 Trial Evaluating the Tolerability, Safety and Efficacy of Ulixacaltamide in Adults with Essential Tremor
Date/Time: Monday, May 15, 2023 at 12:15 p.m. CT
2nd International Tremor Conference (ITC), New York, NY Summary: Essential1 results presentation and scientific talk
Title: Essential 1: Results from a Phase 2 Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Clinical Trial to Evaluate the Tolerability, Safety, and Efficacy of Ulixacaltamide in the Treatment of Adults with Essential Tremor
Date/Time: Thursday, May 18, 2023 at 4:20 p.m. EDT
Ulixacaltamide End-of-Phase 2 Meeting Summary: Meeting with U.S. Food and Drug Administration (FDA) to gain alignment on the overall development program and receive feedback on the Phase 3 clinical strategy to support a marketing application for ulixacaltamide
Date/Time: June 2023
Essential1 Results & Key Opinion Leader (KOL) Event
Summary: Company hosted event to discuss full Essential1 results and provide insights into ulixacaltamide Phase 3 program with participation from ET KOLS
Date/Time: June 2023 (additional details to follow)
The company hosted event will be available via live webcast through the Events & Presentations page of the Investors + Media section of the company’s website at www.praxismedicines.com. A replay of the webcast will be available on Praxis’ website for 90 days following the event.
About Ulixacaltamide
Ulixacaltamide is a differentiated and highly selective small molecule inhibitor of T-type calcium channels designed to block abnormal neuronal burst firing in the Cerebello-Thalamo-Cortical (CTC) circuit correlated with tremor activity. Ulixacaltamide, the most advanced program within Praxis’ Cerebrum™ small molecule platform, is currently in development for the treatment of essential tremor and as a non-dopaminergic treatment for the motor symptoms of Parkinson’s disease.
About Essential Tremor
Essential Tremor (ET) is the most common movement disorder, affecting roughly seven million people in the United States alone, including approximately two million diagnosed patients. ET is characterized by involuntary rhythmic movement in the upper limbs, with or without tremor in other body locations such as the head, vocal cords, or legs. These tremors significantly disrupt daily living and are progressive in nature, with increases in tremor severity and amplitude commonly observed over the course of the disease. There is only one approved pharmacotherapy for ET, propranolol, a beta blocker approved by the FDA in 1967, that offers limited efficacy and poor tolerability and is contraindicated for comorbidities that affect a significant share of the ET population. Other beta blockers and anti-convulsants are used off-label, though similarly are characterized by limited efficacy and tolerability. For these reasons, approximately 40% of patients who seek pharmacotherapy treatment discontinue within two years.