Introducing the Vega system – HiFi sequencing within reach

The first benchtop HiFi long-read sequencing platform is now here with Vega , named after one of the brightest stars in the sky. This exciting platform builds out the portfolio of PacBio sequencing systems, bringing the luminous HiFi technology of the Revio system to a compact yet powerful platform. Just as celestial bodies have guided explorers for centuries, the Vega system promises to guide scientific discovery into an exciting future.

The Vega platform represents a transformative shift for HiFi long-read sequencing, designed to make this industry-leading technology accessible to any laboratory. By bringing the comprehensive view of the genome only afforded by long reads to the benchtop, the Vega system effectively democratizes long-read sequencing. Vega represents a bold future, allowing scientists to completely transform their vision for their lab, both physically and metaphorically.

With Vega, virtually every lab now has access to the trusted, high-precision long-read sequencing for which PacBio is known. The Vega system maintains the same standards of quality as the Revio system and offers reliable and user-friendly workflows at every stage, from extraction to analysis. As the only known long-read technology to provide 99.9% or better accuracy in every run, the HiFi technology you love is now available at the price, footprint, and throughput you need, no matter your research focus.

What new horizons await with Vega? This platform acts as the north star of your lab, charting a course toward groundbreaking discoveries. With the same long read lengths (≥20 kb) and high accuracy (90% of bases Q30+) as Revio, HiFi sequencing on the Vega system allows you to perform comprehensive variant calling with phasing and 5mC methylation detection at an unparalleled level of detail. With its versatile applications, Vega is perfect for labs seeking to integrate long-read sequencing across a wide range of research projects.

For labs focused on regions of particular interest, like those that may be drivers of disease, the Vega system with its powerful 60 Gb output is a good fit for targeted sequencing. Once notoriously difficult to characterize, these regions can now be comprehensively genotyped with PureTarget, which offers a gene panel for 20 of the most important repeat expansions for human health. PureTarget on the Vega system provides single-base resolution of repeats, precise sizing of long repeats, methylation profiles, and deep coverage to characterize mosaicism, with 48 samples per Vega SMRT Cell at 200x, empowering researchers to drive advancements in human health research. Explore the data yourself at the Vega targeted datasets page .

Whether performing targeted sequencing or other industry-leading applications of HiFi technology like WGS, full-length RNA sequencing with Kinnex kits, or metagenomics, Vega shifts the power to your hands. By enabling individualized control over each sequencing project with customized experimental designs, pre-staged consumables for continuous productivity, and no more waiting to accumulate enough samples to fill a batch, sequencing in house with Vega empowers you to take the helm of your research and accelerate your rate of discovery.

The Vega system integrates seamlessly into your lab’s operations, with the universal HiFi workflow maintaining the reliability and consistency of your results. The Vega consumables are designed for simplicity, with only the Vega SMRT Cell and the Vega sequencing plate containing the sample and chemical reagents needed for sequencing. Both consumables have intuitive, tactile designs and are easy to place onto the Vega system. Paired with the world-class PacBio service and support teams, this streamlined and customizable platform for HiFi sequencing empowers researchers to accelerate scientific discovery.

As evidenced by the excitement at our ASHG Vega launch party , researchers are seeing the potential in the Vega system for their lab: “For someone interested in long-read sequencing, [Vega] introduces a new, affordable option that we are able to have in our lab” (Obed Garcia, University of Kansas).

Priced at USD $169,000, with per-run costs at ~$1,100, Vega makes premium HiFi sequencing affordable without sacrificing quality. Each run provides 60 Gb of high-quality HiFi reads, supporting 600 full-length RNA samples, 9,600 samples using the PureTarget repeat expansion panel, or 200 human genomes per year.

Download the Vega brochure , explore the specifications , or reach out to one of our team members. With HiFi sequencing more accessible than ever before, the path to groundbreaking discoveries is now closer than you think. With Vega, the question isn’t if you’ll make discoveries—it’s what you’ll discover next.

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