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ORIC Pharmaceuticals Announces Enozertinib (ORIC-114) Poster Presentation in HER2 exon 20 NSCLC at the ESMO Asia Congress 2025

Key Takeaway: ORIC Pharmaceuticals announced a poster presentation for enozertinib (ORIC-114) at the ESMO Asia Congress 2025, which will take place from December 5-7, 2025, in Singapore. The poster will feature data from a Phase 1b trial involving previously treated patients with HER2 exon 20 mutant non-small cell lung cancer (NSCLC). In conjunction with the congress, the company will also host a conference call and webcast to discuss the findings.
Price reaction · baseline $11.88 (2025-11-28 close) · 1 other ORIC headline(s) in the window, move may be shared
day 0 close
-6.1%
day 1 · peak
-10.4%
day 3
-4.1%

Market Sentiment Analysis

POSITIVE FACTORS

  • Presentation of new data at a prominent congress enhances visibility.
  • Focus on HER2 exon 20 mutant NSCLC signals commitment to addressing specific cancer types.
  • Enozertinib's classification as a highly selective and brain penetrant inhibitor is promising.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+58%
120-day peak, hindsight
Typical move
10.1%
average across 6 past catalysts
Cash runway
~36 mo
Minimal dilution risk
Lead asset
ORIC-944
Phase 1 · Metastatic Prostate Cancer

Full Press Release Details

SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, Dec. 01, 2025 (GLOBE NEWSWIRE) -- ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today announced a poster presentation highlighting data from a Phase 1b trial of enozertinib (ORIC-114) at the ESMO Asia Congress 2025 taking place December 5-7, 2025 in Singapore. The poster will focus on data in previously treated patients with HER2 exon 20 mutant NSCLC.
Poster presentation details:
Title: Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant
EGFR and HER2 Inhibitor, in Patients with HER2 Exon 20
Mutant NSCLC: Randomized Dose Optimization
Presentation Number: 981P
Session Type and Title: Poster Display session and cocktail
Session Date & Time: Friday, December 5, 2025; 5:15 – 6:15 p.m. SGT
Full abstracts are available for public viewing via the ESMO Asia Congress website.
Conference Call and Webcast Details
In conjunction with the ESMO Asia Congress, ORIC will host a conference call and webcast on Saturday, December 6, 2025, at 8:00 pm ET. To join the conference call via phone and participate in the live Q&A session, please pre-register online here to receive a telephone number and unique passcode required to enter the call. A live webcast and audio archive of the conference call will be available through the investor section of ORIC’s website at www.oricpharma.com. The webcast will be available for replay for 90 days following the presentation.
About ORIC Pharmaceuticals, Inc.

Frequently Asked Questions

What is the focus of ORIC Pharmaceuticals?

ORIC Pharmaceuticals develops treatments targeting therapeutic resistance in oncology.

When is the ESMO Asia Congress 2025?

The ESMO Asia Congress 2025 runs from December 5-7, 2025, in Singapore.

What is Enozertinib (ORIC-114)?

Enozertinib is a highly selective EGFR and HER2 inhibitor for NSCLC patients.

When will ORIC host a conference call?

ORIC's conference call is scheduled for December 6, 2025, at 8:00 pm ET.

Where can I find the conference webcast?

The webcast will be available in the investor section of ORIC’s website.

Last updated: Dec 1, 2025