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ORIC Pharmaceuticals Announces Enozertinib (ORIC-114) Late-Breaking Oral Presentations in EGFR Atypical and EGFR exon 20 NSCLC at the ESMO Asia Congress 2025

Key Takeaway: ORIC Pharmaceuticals will showcase late-breaking presentations on enozertinib (ORIC-114) at the ESMO Asia Congress 2025. The presentations will cover data from a Phase 1b trial focusing on two groups: previously treated patients with EGFR atypical mutant NSCLC and both treated and treatment-naïve patients with EGFR exon 20 mutant NSCLC. This highlights the company's ongoing research into treatments that address therapeutic resistance in cancer.

Market Sentiment Analysis

POSITIVE FACTORS

  • ORIC Pharmaceuticals is presenting promising data on enozertinib at a notable oncology congress.
  • The drug targets specific mutations in NSCLC, showcasing its specialized approach.
  • The presentations are set to be featured in a late-breaking session, highlighting their significance.

Full Press Release Details

SOUTH SAN FRANCISCO and SAN DIEGO, Dec. 03, 2025 (GLOBE NEWSWIRE) -- ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today announced two late-breaking oral presentations highlighting data from a Phase 1b trial of enozertinib (ORIC-114) at the ESMO Asia Congress 2025 taking place December 5-7, 2025 in Singapore. The mini-oral presentation will focus on data in previously treated patients with EGFR atypical mutant NSCLC, and the proffered paper oral presentation will focus on data in previously treated and treatment-naïve patients with EGFR exon 20 mutant NCSLC.
Mini-oral presentation details:
Title: Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant EGFR and HER2 Inhibitor, in Previously Treated NSCLC with EGFR Atypical Mutations: Randomized Dose Optimization and CNS Activity
Presentation Number: LBA15
Session Type and Title: Mini Oral session 1: Thoracic malignancies
Lecture Date and Time: Friday, December 5, 2025; 11:38 – 11:43 a.m. SGT
Proffered paper oral presentation details:
Title: Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant EGFR and HER2 Inhibitor, in EGFR Exon 20 Mutant NSCLC: Randomized Dose Optimization and CNS Activity
Presentation Number: LBA13
Session Type and Title: Proffered Paper session: Thoracic malignancies
Lecture Date and Time: Saturday, December 6, 2025; 10:02 – 10:12 a.m. SGT
Full late-breaking abstracts are available for public viewing via the ESMO Asia Congress website.
Conference Call and Webcast Details
In conjunction with the ESMO Asia Congress, ORIC will host a conference call and webcast on Saturday, December 6, 2025, at 8:00 pm ET. To join the conference call via phone and participate in the live Q&A session, please pre-register online here to receive a telephone number and unique passcode required to enter the call. A live webcast and audio archive of the conference call will be available through the investor section of ORIC’s website at www.oricpharma.com. The webcast will be available for replay for 90 days following the presentation.
About ORIC Pharmaceuticals, Inc.
Dominic Piscitelli, Chief Financial Officer

Frequently Asked Questions

What is the focus of ORIC Pharmaceuticals?

ORIC Pharmaceuticals develops therapies to combat mechanisms of therapeutic resistance.

When is the ESMO Asia Congress 2025 taking place?

The ESMO Asia Congress 2025 is scheduled for December 5-7, 2025.

What will be presented at the ESMO Asia Congress?

Two presentations will showcase data on enozertinib in NSCLC.

How can I join the ORIC conference call?

You can pre-register online for the conference call and Q&A session.

Where can I find the conference webcast?

The webcast will be available on ORIC's investor website for 90 days.

Last updated: Dec 3, 2025