Oragenics Announces Proposed Underwritten Public Offering

Announces Proposed Underwritten Public Offering

- Oragenics, Inc. (NYSE American: OGEN) ("Oragenics" or the "Company") a company focused on

the creation of the Terra CoV-2 vaccine candidate to combat the novel coronavirus pandemic, today announced that it has commenced

a proposed underwritten public offering of common stock of the Company. In addition, the Company expects to grant the underwriter

of the offering, a 45-day option to purchase additional shares of common stock at the public offering price, less underwriting

discounts and commissions. The offering is subject to market and other conditions, and there can be no assurance as to whether

or when the offering may be completed, or as to the actual size or terms of the offering.

Global Partners is acting as sole book-running manager for the offering.

Company intends to use the net proceeds of the offering primarily to continue funding our pre-clinical development of our SARS-CoV-2

vaccine, Terra CoV-2 and our lantibiotics program and for general corporate purposes, including research and development activities,

capital expenditures and working capital.

securities described above are being offered pursuant to a shelf registration statement (File No. 333-235763), which was

declared effective by the United States Securities and Exchange Commission ("SEC") on January 13, 2020. A preliminary

prospectus supplement relating to the offering will be filed with the SEC. Copies of the preliminary prospectus supplement and

the accompanying prospectus relating to this offering may be obtained, when available, at the SEC's website at www.sec.gov.

Electronic copies of the preliminary prospectus supplement may be obtained, when available, from A.G.P./Alliance Global Partners,

590 Madison Avenue, 28th Floor, New York, NY 10022 or via telephone at 212-624-2060 or email: prospectus@allianceg.com.

you invest, you should read the preliminary prospectus supplement and the accompanying prospectus in the registration statement

and other documents Oragenics has filed or will file with the SEC for more complete information about Oragenics and the offering.

press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the Company's securities,

nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would

be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

Inc. is focused on the creation of the Terra CoV-2 vaccine candidate to combat the novel coronavirus pandemic and the further

development of effective treatments for novel antibiotics against infectious disease. The Company is dedicated to the development

and commercialization of a vaccine candidate providing specific immunity from novel coronavirus. The Terra CoV-2 immunization

leverages coronavirus spike protein research conducted by the National Institute of Health. In addition, Oragenics has an exclusive

worldwide channel collaboration with ILH Holdings, Inc. (n/k/a Eleszto Genetika, Inc.), relating to the development of novel lantibiotics.

press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of

1995, as amended, that involve significant risks and uncertainties about Oragenics, including but not limited to statements with

respect to the completion, timing, size, and use of proceeds of the proposed underwritten offering of common stock. Oragenics

may use words such as "expect," "anticipate," "project," "intend," "plan,"

"aim," "believe," "seek," "estimate," "can," "focus,"

"will," and "may" and similar expressions to identify such forward-looking statements. Among the important

factors that could cause actual results to differ materially from those indicated by such forward-looking statements are risks

relating to, among other things, whether or not Oragenics will be able to raise capital, the final terms of the underwritten offering

of common stock, market and other conditions, the satisfaction of customary closing conditions related to the underwritten offering

of common stock, Oragenics' business and financial condition, and the impact of general economic, industry or political

conditions in the United States or internationally. For additional disclosure regarding these and other risks faced by Oragenics,

see disclosures contained in Oragenics' public filings with the SEC, including the "Risk Factors" in the Company's

Annual Report on Form 10-K, as updated by our Form 8-K Report filed with the SEC on May 8, 2020, Quarterly Reports on

Form 10-Q, and prospectus for this offering. You should consider these factors in evaluating the forward-looking statements

included in this press release and not place undue reliance on such statements. The forward-looking statements are made as of

the date hereof, and Oragenics undertakes no obligation to update such statements as a result of new information, except as required

Sullivan, 813-286-7900