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Neurosteroid enantiomer

Phase 2

Mild Traumatic Brain Injury, Concussion | Small molecule | Neurology |Oragenics Inc.|Last Updated: Mar 11, 2025

Success Probability

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Market & Valuation

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Trial Design

Double-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

Neurosteroid enantiomer · 1 trial · 1 indication

Phase 2 1
NCT06870240A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain InjuryMild Traumatic Brain Injury, Concussion
NOT YET_RECRUITING40 Analytics
PHASE2NOT YET_RECRUITING
A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury
Mild Traumatic Brain Injury, ConcussionUnlock trial analytics

Study Endpoints

Primary Endpoints

Patient symptom reporting
Days 2, 5, 10 and 30 post-injurt

Neurological questionnaires for patient symptoms including Rivermead

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Study Design & Arms

AllocationNA
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
92mg of Hydroxy-propyl beta-cyclodextrin as a spray-dried powderPLACEBO_COMPARATORThe placebo is 92mg of Hydroxy-propyl beta-cyclodextrin as a spray-dried powder
ONP-002 treatmentACTIVE_COMPARATORONP-002 is 8mg API and 92 Hydroxy-propyl beta-cyclodextrin as a spray-dried powder

Interventions

NameTypeDescription
Neurosteroid enantiomerDRUGA non-natural synthetic neurosteroid enantiomer considered a new chemical entity
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Eligibility Criteria

Age Range18 Months to 60 Months
SexALL
Healthy VolunteersNo
Study Sites1

7.2.1 Inclusion Criteria Participants with suspected concussion presenting to the emergency department will be included in the study only if they satisfy all the following criteria: 1. Participant or legal representative is willing and capable of giving written informed consent before any study-re...

Countries:Australia
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Frequently asked questions about Neurosteroid enantiomer

What is Neurosteroid enantiomer used for?

Neurosteroid enantiomer, also known as ONP-002, is an investigational small molecule being developed for the treatment of mild traumatic brain injury and concussion. It is currently in Phase 2 clinical development and is not yet approved by regulatory authorities.

What does Neurosteroid enantiomer target?

Neurosteroid enantiomer is a neurosteroid enantiomer, a class of compounds that modulate brain function. As a neurosteroid, it is designed to act on the central nervous system, though the specific molecular target has not been disclosed in available information.

Who makes Neurosteroid enantiomer?

Neurosteroid enantiomer is being developed by Oragenics Inc., a biopharmaceutical company traded on the stock exchange under the ticker symbol OGEN. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with mild traumatic brain injury.

What phase is Neurosteroid enantiomer in?

Neurosteroid enantiomer is currently in Phase 2 clinical development. It is being studied in a Phase 2a pilot trial, which is a randomized, double-blind, placebo-controlled study designed to evaluate the drug's safety, tolerability, pharmacokinetics, and pharmacodynamics in adults with mild traumatic brain injury.

What clinical trials is Neurosteroid enantiomer in?

Neurosteroid enantiomer is being evaluated in one clinical trial, identified as NCT06870240. This is a Phase 2a pilot study in Australia that is not yet recruiting participants. The trial aims to enroll 40 adults with mild traumatic brain injury and will assess the drug's safety, tolerability, pharmacokinetics, and pharmacodynamics.

Is Neurosteroid enantiomer the same as ONP-002?

Yes, Neurosteroid enantiomer is also known as ONP-002. The drug is being developed by Oragenics Inc. under the name ONP-002, and it is currently in Phase 2 clinical trials for the treatment of mild traumatic brain injury and concussion.