Full Press Release Details
Applications of Proteomics
Nautilus Biotechnology
January 9, 2025
On this episode of Translating Proteomics, co-hosts Parag Mallick and Andreas Huhmer of Nautilus Biotechnology discuss how clinical researchers can leverage proteomics for drug development. Some of the themes covered in this episode include:
• Proteomics and pre-clinical models
• How proteomics can drive patient selection
• Choosing the right end points in clinical trials
This post serves as a great companion to Translating Proteomics Episode 8 – Expanding the Druggable Universe with Proteomics .
Find this episode on Apple Podcasts , Spotify , or YouTube .
Browse all episodes of Translating Proteomics.
Chapters
00:00 – 01:06 – Introduction 01:06 – 06:51 – Proteomics in pre-clinical studies 06:51 – 11:40 – The importance of choosing the right model for preclinical work 11:40 – 17:10 – How proteomics is used in Phase I/II clinical trials 17:10 – 19:29 – Proteomics tools in patient selection 19:29 – 24:33 – Useful information that we get from proteomics that we can’t get from genomics or transcriptomics 24:33 – 28:14 – Proteomics in Phase III clinical trials and picking the best indications of drug efficacy 28:14 – 29:19 – Understanding why clinical trials fail 29:19 – End – Outro
Resources
• The National Cancer Institute’s webpage covering how clinical trials work
• Preprint on the miBrain model – An example of a new in vitro brain model
• Wasko et al., 2024 – Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
• Geary et al., 2021 – Discovery and Evaluation of Protein Biomarkers as a Signature of Wellness in Late-Stage Cancer Patients in Early Phase Clinical Trials
• The NCI-MATCH trail: Lessons for precision oncology – Report on a large-scale trial using genomic biomarkers to match cancer patients to treatments
• Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer – Study using proteomics to understand mechanisms of resistance to a cancer drug
Find this episode on Apple Podcasts , Spotify , or YouTube .
Browse all episodes of Translating Proteomics.
Read our preprint to explore novel proteoform data and its potential in drug development.
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