Full Press Release Details
Industry interviews
Nautilus Biotechnology
May 29, 2025
On this episode of Translating Proteomics , host Parag Mallick discusses spatial proteomics with special guest Fiona Ginty Ph.D. Fiona is a Senior Principal Scientist in Precision Diagnostics at the GE Healthcare Technology & Innovation Center. She is a leader in the development of spatial proteomics technologies and their application in precision diagnostics and medicine.
Their discussion covers:
• How Fiona began working in spatial proteomics
• Why spatial biology is important
• What the future holds for spatial biology
Stream this episode on YouTube , Apple Podcasts , or Spotify .
Chapters
00:00 – Introduction 01:54 – Fiona’s journey to biology 05:26 – Fiona’s transition to tool development 07:20 – Working at GE Research 11:26 – Identifying the importance of spatial biology 14:43 – How Cell DIVE TM works 18:25 – The importance of single cell 23:01 – When Fiona realized the technology worked 28:04 – Spatial biology projects Fiona is excited about 30:08 – Fiona’s role in HuBMAP 36:50 – Learnings from HuBMAP so far 38:35 – The future of spatial proteomics in the clinic 46:56 – Current limits on spatial proteomics 49:56 – Current and future uses of AI in spatial proteomics 53:30 – The most exciting thing Fiona learned in her spatial proteomics journey 56:08 – Outro
Resources :
• Method of the Year 2024: Spatial Proteomics
• Paper covering the spatial proteomics technology Fiona worked on at GE Healthcare Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
• HubMAP – Human BioMolecular Atlas Program
• Human Tumor Atlas Network
• Cell DIVE Multiplex Imaging Solution
• Papers discussing what makes colorectal cancer cells undergo apoptosis in response to chemotherapy An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
• Paper discussing how the distance between tumor cells and cytotoxic t-cells correlates to caspase level Spatial effects of infiltrating T cells on neighbouring cancer cells and prognosis in stage III CRC patients – Azimi – 2024 – The Journal of Pathology – Wiley Online Library
• Paper showing it takes 3 hits from cytotoxic t-cells to kill cancer cells Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications
• Paper focused on generating new pathology image patches using AI Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model – PubMed
• Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
• An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution
• Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
• Spatial effects of infiltrating T cells on neighbouring cancer cells and prognosis in stage III CRC patients – Azimi – 2024 – The Journal of Pathology – Wiley Online Library
• Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications
• Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model – PubMed
Acknowledgements
Dr. Ginty wanted to acknowledge the many people she’s worked with on Cell DIVE TM and as part of HuBMAP. She stresses that these are highly collaborative projects, and just some of the many great team members she’s worked with are listed below.
Cell DIVE:
Anup Sood, Sean Dinn, Yunxia Sui, Sanghee Cho, John Graf , Kathleen Bove, Musodiq Bello, Sudeshna Adak, Michael Lazare, Anirban Bhaduri, Thomas Treynor, Dileep Vangasseri, Alberto Santamaria-Pang, Maureen Bresnahan, Micheal Gerdes, Megan Rothman, Colin McCullough, Chris Sevinsky, Liz McDonough, Christine Surrette, Max Seel, Alex Corwin, Bob Filkins, Kevin Kenny, Brion Sarachan, Mike Montalto, Christoph Hergersberg, John Burczak, Jens Rittscher, Steve Zingelewicz, Dr. Sunil Badve (Emory U), Dr. Yesim Gokmen Polar (Emory U), Eli Lilly collaborators
HuBMAP:
Lou Falo (U. Pitt), Arivarasan Karunamurthy (U. Pitt), John Hickey (Duke), Chenchen Zhu (Stanford), Ioannis Vlachos (BIDMC), Liz McDonough (GE HealthCare Technology and Innovation Center [HTIC]), Sammi Abate (GE HealthCare Technology and Innovation Center [HTIC]), Soumya Ghose (GE HealthCare Technology and Innovation Center [HTIC]), Christine Surrette (GE HealthCare Technology and Innovation Center [HTIC]), Dr. Katy Borner (Indiana U)
Share this Article
Stay up-to-date on all things Nautilus
World-class articles, delivered weekly
MORE ARTICLES
Nautilus: Driving a revolution in proteomic analysis
New protein sequencing technology from Nautilus is unlocking the proteome and igniting a proteomics revolution.
Read more
Nautilus: Driving a revolution in proteomic analysis (Part 2)
We give you an inside view on how cross-disciplinary thinking and collaboration will propel us into a proteomics-powered future.
Read more
Interview with Andreas Huhmer – Senior Director of Scientific Affairs and Alliance Management
Andreas, Nautilus Senior Director of Alliance Management, describes why he’s excited to see researchers begin to use the Nautilus Platform.
Read more
Stay up-to-date on all things Nautilus