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Reflections on Proteomics – 2025 Year-End Wrap-Up

Key Takeaway: The article reflects on key developments in proteomics during 2025, highlighting insights from the World HUPO 2025 conference. Key trends include a shift towards application-focused research, increased recognition of proteoforms, and the rise of multiomics studies. Additionally, there is a notable integration of AI into proteomics workflows. Predictions for 2026 are also shared.
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POSITIVE FACTORS

  • Increased focus on applications of proteomics.
  • Growth in discussions about the importance of proteoforms.
  • Rise in multiomics studies and larger scale proteomics.
  • Integration of AI into proteomics workflows.

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MDMA
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Full Press Release Details

Industry interviews
Nautilus Biotechnology
December 23, 2025
On this episode of Translating Proteomics, Parag and Andreas share their reflections on proteomics developments in 2025 largely inspired by their observations at the World HUPO 2025 conference in Toronto. Whether you agree, disagree, or simply want to share some of your own observations on proteomics, please post your thoughts in the comments on YouTube . We look forward to even more exciting developments in 2026!
Subscribe to Translating Proteomics on YouTube , Apple Podcasts , Spotify .

Chapters

00:00 – 00:35 – Intro
00:36 – 07:00 – Increased focus on applications of proteomics and less on method development Learn more about One Health from our conversation with Professor Jennifer Geddes-McAlister: https://youtu.be/JFwvTdkb5bw
07:01 – 12:47 – Increase in people talking about the importance of proteoforms Learn more about proteoforms in our episode featuring proteoform pioneer Professor Neil Kelleher: https://youtu.be/3pPuxVrMxpw
12:47 – 17:26 – An increase in multiomics studies
17:27 – 20:03 – A shift to larger scale proteomics studies For a great example of a multi-platform comparison study, check out Kirsher et al., 2025: https://www.nature.com/articles/s42004-025-01665-1
20:03 – 25:07 – Increased integration of AI into proteomics workflows For an example of how proteomics workflows can be modified with multiomic data, check out Suhre et al., 2025: https://www.nature.com/articles/s41588-025-02413-w
25:08 – 30:05 – Recognition of the need to assess quality across proteomics workflows
30:06 – 32:19 – Less of a focus on spatial proteomics this year than in past years
32:20 – 35: 13 – Parag and Andreas share their predictions for 2026
35:14 – End – Outro
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Frequently Asked Questions

What were the key trends in proteomics for 2025?

Key trends included a focus on applications, discussions on proteoforms, and an increase in multiomics studies.

How is AI being integrated into proteomics?

AI is increasingly being incorporated into proteomics workflows to enhance data analysis and interpretation.

What predictions were made for proteomics in 2026?

The article shares predictions for continued advancements in proteomics, though specifics are not detailed.

What was less emphasized in proteomics this year?

There was a noted decrease in focus on spatial proteomics compared to previous years.

Last updated: Dec 23, 2025