Full Press Release Details
Nautilus and our Platform
Nautilus Biotechnology
June 10, 2024
While it’s commonly stated that there are about 20,000 proteins encoded in the human genome, these 20,000 proteins can be modified in many ways to produce potentially millions of proteoforms with modified functions, localizations, half-lives, and more. Each proteoform is defined by the full set of modifications it has, whether those modifications come from alternative splicing, post-translational modification, or any other source. Thus identifying proteoforms requires single-molecule analysis of full-length proteins. Knowing the proteoform makeup of a cell, tissue, or organism may reveal the molecular underpinnings of its biology and enable scientists to develop more effective biomarkers and drugs. In this animation, we show how the Nautilus TM Proteome Analysis Platform is uniquely designed to enable single-molecule analysis of intact proteoforms for in-depth studies of proteoform biology that are not possible on other platforms.
Watch the animation above for a visual deep dive into proteoform studies on the Nautilus Platform.
Read our preprint to explore novel proteoform data and the quantitative benefits of Iterative Mapping of proteoforms.
Share this Article
Stay up-to-date on all things Nautilus
World-class articles, delivered weekly
MORE ARTICLES
Nautilus: Driving a revolution in proteomic analysis
New protein sequencing technology from Nautilus is unlocking the proteome and igniting a proteomics revolution.
Read more
A brief introduction to PrISM – The theoretical framework underpinning the Nautilus platform
Learn about Protein Identification by Short epitope Mapping (PrISM) - The theoretical framework underpinning the Nautilus Platform.
Read more
Nautilus: Driving a revolution in proteomic analysis (Part 2)
We give you an inside view on how cross-disciplinary thinking and collaboration will propel us into a proteomics-powered future.
Read more
Stay up-to-date on all things Nautilus