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except as required by law. Market Data Certain information contained in this Presentation relates to or is based on third-party studies, publications, surveys and NewAmsterdam's own internal estimates and research. In addition, all of the
market data included in this Presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, while NewAmsterdam believes its internal research is reliable,
such research has not been verified by any independent source and NewAmsterdam cannot guarantee and makes no representation or warranty, express or implied, as to its accuracy and completeness. Trademarks This Presentation contains trademarks,
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TM or SM symbols, but such references are not intended to indicate, in any way, that NewAmsterdam will not assert, to the fullest extent permitted under applicable law, their rights or the right of the applicable licensor to these trademarks,
service marks and trade names. 2 PROPRIETARY
NewAmsterdam is developing oral obicetrapib as CETPi to address major
unmet need in hypercholesterolemia and other cardiometabolic diseases O B I C E T RA P I B Company history: Achievements and milestones: Significant unmet need for oral LDL-lowering therapy as adjunct to statins: 30mm+ patients in US/EU5 are
not achieving LDL-lowering goals Mid-'20: Founded after despite standard-of-care Fully-funded through 2026 spin-out from Amgen including CVOT readout and Simple, oral, once-daily, low dose CETP inhibitor with strong
LDL- potential global launch Jan '21: $196M Series A lowering efficacy and safety observed through Phase 2b: Significant number of June '22: >$1B European ~50% LDL-lowering observed on top of
high-intensity statins patients randomized in Phase 3 license with Menarini Group to-date, first DSMB meeting (including 142.5M committed Strong safety and tolerability in >600 pts completed capital + significant back-end
economics) Robust effects on ApoB, non-HDL-C, HDL-C and Lp(a) Late-stage inflection points expected from 2023-2025 Nov '22: NASDAQ listing Convenient oral format + low cost of goods sold (COGS) enables broad
(including Phase 2 & 3 clinical (NAMS) with $328M total market access strategy to address existing unmet need readouts and registrational proceeds ($93M from FLAC trust filings) in deSPAC, plus $235M PIPE co- lead by Frazier and Bain)
Pipeline expansion potential >30M ~50% in Alzheimer's disease and $3-4B+ Jan '23: ~$1B market cap addressable LDL-lowering diabetes global market and $450M cash patient observed in opportunity population Phase 2b 3 PROPRIETARY
Expert cardiometabolic leadership supported by top investors Michael
Davidson, M.D. John Kastelein, M.D. Douglas Kling Lina Gugucheva David Topper Marc Ditmarsch, M.D. CEO CSO COO CBO CFO CDO SANDER SLOOTWEG JULIET JAMIE NICHOLAS LOU MICHAEL DAVIDSON JOHN SEASONED BOARD AUDET TOPPER DOWNING LANGE KASTELEIN OF
Managing Partner, Partner, Managing Partner, Partner, Partner, CEO, NewAmsterdam CSO, NewAmsterdam DIRECTORS: Forbion Forbion Frazier Life Sciences Bain Capital Asset Management Pharma Pharma Ventures BACKED BY TOP TIER INVESTORS: 4 PROPRIETARY
Net proceeds expected to fund obicetrapib development through several
value-creating milestones 2022 2023 2024 2025 2026 1H 2H 1H 2H 1H 2H 1H 2H 1H 2H Phase 3 BROADWAY Trial Lipid Mono Study BROADWAY Ph3 (ASCVD; LDL-C 55 mg/dL; n=2,400) LDL regulatory filing Phase 3 BROOKLYN Trial BROOKLYN Ph3 Lipid Mono Study
(HeFH; LDL-C 70 mg/dL; HeFH; n=300) Obicetrapib MACE Monotherapy Phase 3 CVOT PREVAIL Trial PREVAIL CVOT regulatory Product (ASCVD or HeFH; LDL-C 70 mg/dL; n=9,000) filing (obicetrapib 10mg) Phase 2b Japan Trial Japan Ph2b (LDL-C
70 mg/dL; n=9,000) LEGEND China BA Study China BA Initiation (Healthy Volunteers; n=36 SAD/MAD) Enrollment complete Ezetimibe FDC Phase 2b ROSE2 Trial Ph3 readout Product ROSE2 Ph2b (LDL-C 70 mg/dL; n=114) (obicetrapib 10mg + CVOT
readout ezetimibe 10mg) Ph2 readout Alzheimer's Phase 2a Alzheimer's Product Disease Trial China BA readout Alzheimer's Ph2a (proprietary (n=10-15) dose/formulation incorporating obicetrapib) PROJECTED CASH RUNWAY THROUGH
2026 Note: Other than as noted, the pipeline represents trials that are currently ongoing. Projections are subject to inherent limitations. Actual results may differ from expectations. The timing of regulatory submissions is subject to additional
discussions with regulators. 5 PROPRIETARY Neuro- Cardiovascular metabolic
Obicetrapib to Treat Cardiovascular Disease 6
Despite availability of statins, CVD remains the leading cause of death
worldwide (1) 231 million Adults in US/EU5 with hypercholesterolemia (2) 84 million Treated with prescription medication (3) <1 million post- statin Key factors limiting penetration 22 million (3) 8 million (4) Still above patients
Statin-intolerant include product limitations LDL-C target Treated with current and market access hurdles branded options Does not yet factor in new U.S. guidance 30 million lowering LDL-C goals to 55 mg/dL for very high Patients with risk
patients, which will grow addressable patient population residual need Sources: Trinity NewAmsterdam Market Research Summary; Trinity quantitative market research with N = 100 PCPs and Cardiologists; Bloomberg Prescription Data; IQVIA Rx Tracker.
(1) Literature review suggesting hypercholesterolemia prevalence of ~94mm in the US (average of He et al. 2020, Mercado et al. 2015, Muntner et al. 2013) and ~137mm in EU5 (average of Gomez-Huelgas et al. 2010, Guallar-Castillon et al. 2012, Tragni
et al. 2012, Grau et al. 2011). (2) 2020 US prescription data for statins, PCSK9s, and bempedoic acid were pulled from the Bloomberg Prescription Data Portal that Trinity subscribes to; assuming 12 scripts/year per patient and 70% compliance for
PCSK9s (based on PCSK9 literature) and 59% compliance for statins & Nex/Nex (based on statin literature) treated patient volume estimates were derived from the prescription data and extrapolated to the EU5. (3) 8mm statin-intolerant & 22mm
above LDL-C target: Percentage of patients in each category estimated from Trinity quantitative market research and the - percentages were then applied to the estimated 84mm treated number above. 7 (4) <1mm branded patients: 2020 US
prescription data for Repatha, Praluent, and Nexletol/Nexlizet were pulled from the Bloomberg Prescription Data Portal that Trinity subscribes to; assuming 12 scripts/year and 70% compliance for PCSK9s (based on PROPRIETARY PCSK9 literature) and 59%
compliance for Nex/Nex (based on statin literature) patient volume estimates were derived from the prescription data and extrapolated to the EU5.
Current post-statin LDL-lowering products all fall short of the profile
patients need Patients need a drug that fits Ezetimibe Nexletol PCSK9 the following profile: (1) (1) Modest Modest Strong Strong Efficacy Oral, Oral, Injectable, Oral, Low Dose High Dose High Dose Administration/ 10mg 180mg ~140-150mg Low Dose Dose
Disruptive Price, Very High Price, Generic, Branded Price, Market Access/Price Highly Restricted Access Broad Access Broad Access Limited Access (High COGS) (Low COGS) Safe, Safe, FDA Label: Safe Safety & Tolerability Tendon rupture & gout
warning Painful injection site reactions Well Tolerated Well-Tolerated Strong Lp(a) Lowering, HDL Raising has Potential Ancillary None None Modest Lp(a) Lowering Benefits in Alzheimer's and Benefit(s) Diabetes Note: Novartis' stated
price of Inclisiran to be approximate to net prices of PCSK9 mAbs. (1) Lighter shaded region of bar chart represents the additional potential efficacy for fixed dose combinations with ezetimibe. 8 PROPRIETARY
~50% LDL-C reduction efficacy would be virtually identical to PCSK9
injectables and is substantially better than other oral therapies Cross trial comparison of LDL-C reduction across different approaches (in %) Obicetrapib Anacetrapib Evacetrapib Dalcetrapib Ezetimibe Nexletol Repatha Praluent Leqvio * 1 2 3 4 5 6 7
8 10mg 100mg 130mg 600mg 10mg 180mg 420mg 150mg 284mg 0 -7 -10 -15 -17 -20 -21 -25 -30 There is Obicetrapib currently -40 mono dose no approved observed to oral drug with reduce LDL-C LDL-lowering by 51% in -46 -47 potency in the Phase 2b -50 50%
range clinical trial -51 Obicetrapib + ezetimibe FDC -60 Prior CETP inhibitors Existing oral therapies PCSK9 injectables expected to reduce Ezetimibe is generic, Nexletol bears FDA label LDL by ~60% for tendon rupture, gout The trials represented
were selected due to their shared features that reflect the Phase 3 obicetrapib studies. Selecting trials with shared features allows for a potentially more accurate comparison of the LDL-C lowering results, with factors being considered such as: a)
presence of intensive LDL-lowering therapy including (high intensity) statins and PCSK9 inhibitors, b) patient population - ASCVD or ASCVD risk equivalent patients (including primary hypercholesterolemia and HefH) and c) where possible,
selected studies where LDL-C measured by preparative ultracentrifugation (PUC ) as opposed to Friedewald; noted below are those instances where PUC was not used - this is important because at low LDL-C levels (< 50 mg/dL), calculated LDL-C
by Friedewald is overestimated; certain significant deviations from these parameters are provided in the footnotes. Note: The above trials and data do not represent head-to-head comparisons. Actual results may differ from expectations. Sources: *
Circulation. 2021;144:e564-e593 17065. 1. Bowman, L et al. N Engl J Med 2017. 2. Amirhossein, S et al. Curr Pharmaceutical Design 2016. Meta-analysis - Also included hyperlipidaemia patients. LDL-C measured using direct assays and Friedewald.
3. de Grooth et al. Circulation 2002. LDL-C measured only using Friedewald and did not require subjects to be on prior statin therapy or present with ASCVD. 4. PI Zetia table 7. refers to; Gagne, C et al. Am J Cardiol 2002. LDL-C measured only using
Friedewald. 5. PI Nexletol; study 2. refers to; Goldberg, A et al. JAMA 2019;322(18):1780-1788. LDL-C measured using Friedewald and direct assay for LDL-C <50 mg/dL. 6. PI Repatha; study 3. refers to; Blom, D et al. N Engl J Med 2014. Also 9
PROPRIETARY included hyperlipidaemia patients. 7. PI Praluent; study 3. refers to; Kereiakes, D et al. Am Heart J 2015. 8. PI Leqvio; study 1. Refers to; Ray, K. N Engl J Med 2020. % LDL-C change versus baseline
Obicetrapib has potential to solve a substantial unmet medical need in
dyslipidemia (1) 231mm Patients with >30mm patients not sufficiently addressed by available treatment options hyperlipidemia OBICETRAPIB Fewer than 1mm patients treated with 10mg current branded options: ~50% LDL-lowering observed in Phase
2b 180mg Potential for attractive pricing to unlock broad access Bempedoic Acid PCSK9s Strong safety and tolerability profile THE SOLUTION observed o Payors highly restrict access THE Convenient once-daily oral tablet o Low
prescriber enthusiasm PROBLEM High prescriber and payor enthusiasm o Relatively low patient compliance (2) $3-4B global market opportunity Sources: (1) Literature review suggesting hypercholesterolemia prevalence of ~94mm in the US (average
of He et al. 2020, Mercado et al. 2015, Muntner et al. 2013) and ~137mm in EU5 (average of Gomez-Huelgas et al. 2010, Guallar- Castillon et al. 2012, Tragni et al. 2012, Grau et al. 2011). 10 PROPRIETARY (2) Value derived from top-down
epidemiology-based market model for obicetrapib; assumptions derived from secondary research / literature and primary market research with US and EU5 physicians and payers.
US market research indicates strong prescriber and payor enthusiasm,
wide window of pricing opportunity to enable broad market access strategy Strong enthusiasm from prescribers Broad market access opportunity: and payors: Market access hurdles plague existing brands: PRESCRIBER ENTHUSIAM: "There is a lot of
documentation involved as Nexletol PCSK9i Obicetrapib $$$$ we're really trying to restrict to the highest PRICE IS TOO HIGH risk patients that actually need these costly for meaningful access (~$6K) products" Efficacy Moderate/Low* High
High -Payor $$$ MODEST EFFICACY, comparable to generics, Safety/ Moderate High High Tolerability make any branded price hard to justify (~$4K) Route of High Low High Administration Obicetrapib positioned to unlock significantly better access:
Low COGS enables favorable pricing PAYOR ENTHUSIAM: Strong LDL-C lowering, virtually same as injectables $$ "Biggest need (is) a product that works like the PCSK9s but with a more Simple, convenient oral pill gives payors
confidence around patient convenient ROA and no diabetes risk" compliance Ancillary benefits for diabetes prevention, Lp(a) lowering "Fulfills an important unmet need" Key: Blue cells denote high ratings (6.5 - 9) /
Yellow cells denote moderate ratings (5 - 6.4) / Red cells denote lowest ratings (1 - 4.9); ratings were given on a 9-point scale, thus lower / red ratings actually reflect the ~midpoint of the scale. *In our survey, obicetrapib mono
therapy received a moderate score and obicetrapib FDC therapy received a high score. Source for other scores: Trinity quantitative market research; N = 100 (50 PCPs + 50 cardiologists). 11 PROPRIETARY
Disease background and summary of clinical data 12
LDL-C, ApoB and Lp(a) are causal in the development of atherosclerosis
and heart disease ApoB is a molecule that envelopes LDL in a 1:1 ratio LDL-C ApoB: Each LDL-C particle contains one ApoB molecule ApoB-containing particles can become trapped in the arterial wall High ApoB levels lead to
atherosclerotic plaque formation and buildup over time Each Lp(a) particle has a LDL particle that contains an Lp(a) ApoB wrapped with an Apo(a) molecule Atherosclerotic plaque Genetic mutations can lead to higher Lp(a) levels in certain
individuals These individuals are at a higher risk of developing arterial plaques and experiencing adverse Reducing the number of ApoB and Lp(a) particles cardiovascular events in circulation is critical to halting plaque build-up and
reducing CV risk Source: Adapted from Ference BA, Kastelein JPP, Catapano AL. JAMA, 2020;324(6):595-596. 13 PROPRIETARY
In ROSE Phase 2b clinical trial, obicetrapib demonstrated robust LDL-C
lowering as adjunct (1) to high intensity statins Preparative ultra-centrifugation (PUC) is "gold-standard" for LDL-C quantification Median (min, max) LDL-C levels (mg/dL) at baseline and EoT Placebo Obicetrapib 5mg Obicetrapib 10mg 10
Time Placebo Obicetrapib Obicetrapib 5mg 10mg 0 90.0 95.0 88.0 Baseline (63, 204) (54, 236) (39, 207) -10 Median -7 N=40 N=39 N=40 86.0 -20 53.0 49.5 EoT (43, 137) (13, 126) (23, 83) Median -30 N=39 N=39 N=40 -6.5 -41.45 -50.75 % Change -40 from
Baseline (-53.9, 31.6) (-71.2, 62.3) (-76.9, 15.6) -41 (median) N=39 N=38* N=40 -50 -51 % Change from -37.98 -44.15 -4.76 Baseline -60 (--44.80, -31.17) (-50.95, -37.35) (-11.74, 2.22) LS mean (95% CI) P-value 0.1814 <0.0001 <0.0001 * In