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MacroGenics (MGNX) Crashed 28% After Pausing Phase 2 TAMARACK Study, Class Action Accuses Company of Misleading Investors Over Cancer Drug Trial – Hagens Berman

Key Takeaway: MacroGenics Inc. experienced a 28% share price drop after the Phase 2 TAMARACK study on its cancer drug, vobra duo, was paused due to safety recommendations. The decision to halt the study came after interim data revealed an alarming rate of serious side effects, including five patient deaths. In the wake of these events, a class-action lawsuit has been filed against the company, claiming they misled investors about the drug's safety and efficacy. Analyst downgrades have followed the negative news, compounding the ongoing challenges for the firm.
Price reaction · baseline $3.25 (2024-09-06 close) · 1 other MGNX headline(s) in the window, move may be shared
day 0 close
+6.2%
day 1
+9.5%
day 3 · peak
+11.1%

Market Sentiment Analysis

POSITIVE FACTORS

  • MacroGenics had previously shown promising results for vobra duo.
  • A significant price rise of 30% was noted after a prior safety data release.

CONCERNS & RISKS

  • The Phase 2 TAMARACK study was paused due to safety concerns.
  • Five patient deaths were reported in the study, leading to a 77% share price drop.
  • A class-action lawsuit alleges the company misled investors about drug safety.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+186%
120-day peak, hindsight
Typical move
5%
average across 4 past catalysts
Cash runway
~13 mo
Low dilution risk
Lead asset
Teplizumab
Phase 2 · Type 1 Diabetes Mellitus

Full Press Release Details

SAN FRANCISCO, Sept. 09, 2024 (GLOBE NEWSWIRE) -- Hagens Berman urges MacroGenics, Inc. (NASDAQ: MGNX) investors who suffered substantial losses to submit your losses now.
Class Period: Mar. 7, 2024 – May 9, 2024
Lead Plaintiff Deadline: Sept. 24, 2024
Contact the Firm Now: MGNX@hbsslaw.com, 844-916-0895
Class Action Lawsuit Against MacroGenics, Inc. (MGNX):
On July 30, 2024, shares in beleaguered pharmaceutical company MacroGenics crashed after the company provided an update for the Phase 2 TAMARACK study on its experimental cancer drug, vobra duo. The company revealed that the study’s Independent Data Monitoring Committee recommended discontinuing additional vobra duo therapy in the study. The company said it agreed with the recommendation, citing patient safety. In response, the price of MacroGenics shares crashed 28% on July 31, 2024 and, unsurprisingly, certain analysts downgraded the stock.
The disclosure came on the heels of a class-action lawsuit that has been filed against MacroGenics alleging that it misled investors about the safety and efficacy of vobra duo. The suit, filed in the Southern District of New York, centers on the company’s statements regarding data from a Phase 2 clinical trial known as TAMARACK.
Previously, in the lead-up to the American Society of Clinical Oncology (ASCO) meeting in March 2024, MacroGenics painted a positive picture of vobra duo’s safety and efficacy. Executives suggested that the drug was showing promising results in patients with metastatic castration-resistant prostate cancer (mCRPC). However, when the company released interim safety data in April, it revealed that the drug had a higher-than-expected rate of serious side effects.
On Apr. 3, 2024, MacroGenics released interim safety data from the TAMARACK study, as detailed in an abstract submitted to ASCO on Feb. 6, 2024. The company stated, “Preliminary safety data from TAMARACK suggest that reducing the dose and frequency of vobra duo improves its safety and tolerability in men with mCRPC.” This announcement led to a significant increase in MacroGenics’ share price, which rose by $4.11, or approximately 30%, on Apr. 4, 2024.
But the euphoria was short-lived. On May 10, 2024, MacroGenics disclosed that five patients in the study had died. This revelation caused the company’s share price to plummet by $11.36, or about 77%, on the same day, prompting numerous analyst downgrades.
“We’re investigating whether MacroGenics may have downplayed safety concerns associated with vobra duo to inflate its stock price,” said Reed Kathrein, the Hagens Berman partner leading the investigation.
If you invested in MacroGenics and have substantial losses submit your losses now »
If you’d like more information about the MacroGenics case and our investigation, read more »
Hagens Berman is a global plaintiffs’ rights complex litigation firm focusing on corporate accountability. The firm is home to a robust practice and represents investors as well as whistleblowers, workers, consumers and others in cases achieving real results for those harmed by corporate negligence and other wrongdoings. Hagens Berman’s team has secured more than $2.9 billion in this area of law. More about the firm and its successes can be found at hbsslaw.com. Follow the firm for updates and news at @ClassActionLaw.

Frequently Asked Questions

What caused MacroGenics' stock to crash?

Shares of MacroGenics plummeted after the Phase 2 TAMARACK study updates recommending the discontinuation of vobra duo therapy for patient safety.

When is the deadline for lead plaintiffs in the MacroGenics lawsuit?

The deadline for lead plaintiffs in the MacroGenics lawsuit is September 24, 2024.

What were the major safety concerns with vobra duo?

Vobra duo presented a higher-than-expected rate of serious side effects, leading to increased scrutiny and stock downgrades.

How much did MacroGenics' stock fall on May 10, 2024?

MacroGenics' stock dropped by $11.36, approximately 77%, on May 10, 2024, after five patient deaths were disclosed.

Who is leading the investigation into MacroGenics?

Reed Kathrein is leading the investigation into whether MacroGenics downplayed safety concerns regarding vobra duo.

Last updated: Sep 9, 2024