Relevant portion of the transcript of the oral presentation by Jazz Pharmaceuticals plc at the J.P. Morgan Healthcare Conference in San Francisco, California on

Relevant portion of the transcript of the oral presentation by Jazz Pharmaceuticals plc at the J.P. Morgan Healthcare Conference in San Francisco,

California on January 13, 2020:

Bruce Cozadd, Chairman & CEO, Jazz Pharmaceuticals plc

I have to say in 2019 we achieved record revenues.

I will make forward-looking statements today. Those are subject to risks and uncertainties. Please see our SEC filings for more information. I ll also

refer to certain non-GAAP financial measures. We do, of course, provide a full reconciliation to GAAP in the appendix to this presentation, which is posted on our website.

I will refer to guidance. Unless I specifically say

otherwise, I m referring to that guidance as of the time it was provided on November 5, 2019.

With reference to slide 8: I

can comment today and say that Xyrem, in fact, did have net sales within our prior guidance, in fact, right at the very top end. This was excellent continued performance by Xyrem with 5.5% revenue bottle growth over 2018 Erwinaze continued to

be supply-challenged. We did end the year within our guidance, with very slight growth, essentially flat to 2018. Defitelio continued its growth, double-digit growth, and did have sales within our guidance. And Vyxeos had very nice growth as well,

particularly in Europe, post our launch of the product. We did come in within our guidance, although at the low end for the year.

With reference to slide 9: So if we

add all those together, we were comfortably within our guidance on top-line revenues, which, if we look at the longer picture, gives us a 13% compound annual growth rate over the past 5 years. Now, it s important to note that with that revenue

growth, we ve continued to grow the bottom line with over 40% of our top-line revenues dropping to after-tax adjusted net income. And looked out on a per share basis, we see about a 15% growth. Now, I will say we haven t finished all of

our accounting yet so that s still based on the prior guidance.

With reference to slide 10: We ve roughly quadrupled our R&D investment over this period you can see that by R&D

spend as a percentage of revenues. On top of that revenue growth, we ve invested a greater fraction of that into our R&D.

Relevant slides from Jazz Pharmaceuticals

plc s presentation at the J.P. Morgan Healthcare Conference in San Francisco, California on January 13, 2020:

Meaghan Narcolepsy Patient th 38 Annual J.P. Morgan Healthcare

Forward-Looking Statements "SAFE HARBOR STATEMENT UNDER THE

PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995 This slide deck and the accompanying oral presentation contain forward-looking statements, including, but not limited to, statements related to Jazz Pharmaceuticals' future financial and

operating results, including 2019 financial guidance, 2020 goals and expectations for growth; the company's corporate development efforts; the company's growth strategy; future product sales and volume; planned sales and marketing and

related efforts; future inventory and supply challenges; planned, ongoing and future clinical trials and other product development activities, including for JZP-458; regulatory events such as the potential EMA approval of the company's MAA for

Sunosi and the potential FDA approval of lurbinectedin and additional planned regulatory submissions such as the company's NDA for JZP-258 (with the redemption of a priority review voucher); ongoing and future product launches, including the

recent launch of Sunosi in the U.S. and its anticipated potential launch in the EU; the timing of such events and activities; and other statements that are not historical facts. These forward-looking statements are based on the company's

current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward- looking statements

as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: maintaining or increasing sales of and revenue from Xyrem (sodium oxybate) oral solution; effectively commercializing

the company's other products and product candidates; the time-consuming and uncertain regulatory approval process, including the risk that the company's current and planned regulatory submissions, including the Sunosi MAA, planned

JZP-258 NDA, and potential JZP-458 BLA may not be submitted, accepted or approved by applicable regulatory authorities in a timely manner or at all; the effectiveness of the license agreement for lurbinectedin upon HSR clearance; costly and

time-consuming pharmaceutical product development and the uncertainty of clinical success, including risks related to failure or delays in initiating or completing clinical trials; protecting and enhancing the company's intellectual property

rights; delays or problems in the supply or manufacture of the company's products and product candidates; the company's ability to maintain rights to its products and product candidates, including Erwinaze; complying with applicable U.S.

and non-U.S. regulatory requirements; government investigations and other actions; obtaining and maintaining adequate coverage and reimbursement for the company's products; identifying and acquiring, in-licensing or developing additional

products or product candidates, financing these transactions and successfully integrating acquired businesses; the company's ability to realize the anticipated benefits of its collaborations with third parties for the development of product

candidates; the ability to achieve expected future financial performance and results and the uncertainty of future tax and other provisions and estimates; and other risks and uncertainties affecting the company, including those described from time

to time under the caption "Risk Factors" and elsewhere in Jazz Pharmaceuticals plc's Securities and Exchange Commission filings and reports (Commission File No. 001-33500), including the company's Quarterly Report on Form

10-Q for the quarter ended September 30, 2019 and future filings and reports by the company. Other risks and uncertainties of which the company is not currently aware may also affect the company's forward-looking statements and may cause

actual results and the timing of events to differ materially from those anticipated. The forward-looking statements made in this slide deck and the accompanying oral presentation are made only as of the date hereof or as of the dates indicated in

the forward-looking statements, even if they are subsequently made available by the company on its website or otherwise. The company undertakes no obligation to update or supplement any forward-looking statements to reflect actual results, new

information, future events, changes in its expectations or other circumstances that exist after the date as of which the forward-looking statements were made. 2 38th Annual J.P. Morgan Healthcare Conference January 13, 2020Forward-Looking Statements

"SAFE HARBOR STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995 This slide deck and the accompanying oral presentation contain forward-looking statements, including, but not limited to, statements related to Jazz

Pharmaceuticals' future financial and operating results, including 2019 financial guidance, 2020 goals and expectations for growth; the company's corporate development efforts; the company's growth strategy; future product sales

and volume; planned sales and marketing and related efforts; future inventory and supply challenges; planned, ongoing and future clinical trials and other product development activities, including for JZP-458; regulatory events such as the potential

EMA approval of the company's MAA for Sunosi and the potential FDA approval of lurbinectedin and additional planned regulatory submissions such as the company's NDA for JZP-258 (with the redemption of a priority review voucher); ongoing and

future product launches, including the recent launch of Sunosi in the U.S. and its anticipated potential launch in the EU; the timing of such events and activities; and other statements that are not historical facts. These forward-looking statements

are based on the company's current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in

such forward- looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: maintaining or increasing sales of and revenue from Xyrem (sodium oxybate) oral

solution; effectively commercializing the company's other products and product candidates; the time-consuming and uncertain regulatory approval process, including the risk that the company's current and planned regulatory submissions,

including the Sunosi MAA, planned JZP-258 NDA, and potential JZP-458 BLA may not be submitted, accepted or approved by applicable regulatory authorities in a timely manner or at all; the effectiveness of the license agreement for lurbinectedin upon

HSR clearance; costly and time-consuming pharmaceutical product development and the uncertainty of clinical success, including risks related to failure or delays in initiating or completing clinical trials; protecting and enhancing the

company's intellectual property rights; delays or problems in the supply or manufacture of the company's products and product candidates; the company's ability to maintain rights to its products and product candidates, including

Erwinaze; complying with applicable U.S. and non-U.S. regulatory requirements; government investigations and other actions; obtaining and maintaining adequate coverage and reimbursement for the company's products; identifying and acquiring,

in-licensing or developing additional products or product candidates, financing these transactions and successfully integrating acquired businesses; the company's ability to realize the anticipated benefits of its collaborations with third

parties for the development of product candidates; the ability to achieve expected future financial performance and results and the uncertainty of future tax and other provisions and estimates; and other risks and uncertainties affecting the

company, including those described from time to time under the caption "Risk Factors" and elsewhere in Jazz Pharmaceuticals plc's Securities and Exchange Commission filings and reports (Commission File No. 001-33500), including the

company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2019 and future filings and reports by the company. Other risks and uncertainties of which the company is not currently aware may also affect the company's

forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. The forward-looking statements made in this slide deck and the accompanying oral presentation are made only as of the date

hereof or as of the dates indicated in the forward-looking statements, even if they are subsequently made available by the company on its website or otherwise. The company undertakes no obligation to update or supplement any forward-looking

statements to reflect actual results, new information, future events, changes in its expectations or other circumstances that exist after the date as of which the forward-looking statements were made. 2 38th Annual J.P. Morgan Healthcare Conference

Robust Evolution of Jazz Over Past 5 Years BUSINESS EXPANSION,

INCLUDING NEAR DOUBLING OF REVENUES 3 Key Commercialized Products 5 2 Total Revenues $1.2B $2.1-$2.2B 5 Launches Launches 1 Launch (since 2016) 2014 2019 Employees ~870 ~1,600 R&D Projects 8 > 25 1 2 R&D Spend as % of Revenues 6% 11-13% 1

2 Non-GAAP adjusted R&D spend, unaudited. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that, for the year ended December 31, 2019, reported total revenues will meet the guidance range provided

on November 5, 2019. Jazz Pharmaceuticals has not finalized its financial results for the year ended December 31, 2019 and actual results may differ. 5 38th Annual J.P. Morgan Healthcare Conference January 13, 2020Robust Evolution of Jazz Over Past

5 Years BUSINESS EXPANSION, INCLUDING NEAR DOUBLING OF REVENUES 3 Key Commercialized Products 5 2 Total Revenues $1.2B $2.1-$2.2B 5 Launches Launches 1 Launch (since 2016) 2014 2019 Employees ~870 ~1,600 R&D Projects 8 > 25 1 2 R&D Spend

as % of Revenues 6% 11-13% 1 2 Non-GAAP adjusted R&D spend, unaudited. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that, for the year ended December 31, 2019, reported total revenues will meet

the guidance range provided on November 5, 2019. Jazz Pharmaceuticals has not finalized its financial results for the year ended December 31, 2019 and actual results may differ. 5 38th Annual J.P. Morgan Healthcare Conference January 13,

Broad Product Portfolio Contributing to Growing Revenues 2019 NET

PRODUCT SALES PROJECTED INCREASE 11-15% OVER 2018 1 NET PRODUCT SALES $ in millions $1,600-$1,640 $160-$195 $1,405 $160-$180 $175 $149 $120-$135 $101 2 2 2 2 2018 2019G 2018 2019G 2018 2019G 2018 2019G Net Product Sales Charts Not Drawn to Same

Scale 1 2 2018 audited. G=Guidance. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that, for the year ended December 31, 2019, reported Xyrem, Erwinaze, Defitelio and Vyxeos net product sales will

meet the guidance range provided on November 5, 2019; with Xyrem at the high end of the guidance range and Vyxeos at the low end of the guidance range. The company expects Xyrem 2019 volume growth to be 5.5%. Jazz Pharmaceuticals has not finalized

its financial results for the year ended December 31, 2019 and actual results may differ. 8 38th Annual J.P. Morgan Healthcare Conference January 13, 2020Broad Product Portfolio Contributing to Growing Revenues 2019 NET PRODUCT SALES PROJECTED

INCREASE 11-15% OVER 2018 1 NET PRODUCT SALES $ in millions $1,600-$1,640 $160-$195 $1,405 $160-$180 $175 $149 $120-$135 $101 2 2 2 2 2018 2019G 2018 2019G 2018 2019G 2018 2019G Net Product Sales Charts Not Drawn to Same Scale 1 2 2018 audited.

G=Guidance. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that, for the year ended December 31, 2019, reported Xyrem, Erwinaze, Defitelio and Vyxeos net product sales will meet the guidance range

provided on November 5, 2019; with Xyrem at the high end of the guidance range and Vyxeos at the low end of the guidance range. The company expects Xyrem 2019 volume growth to be 5.5%. Jazz Pharmaceuticals has not finalized its financial results for

the year ended December 31, 2019 and actual results may differ. 8 38th Annual J.P. Morgan Healthcare Conference January 13, 2020

Strong Financial Execution CONSISTENTLY DELIVERING MORE THAN 40% OF

REVENUES TO THE BOTTOM LINE 1 ADJUSTED NET INCOME TOTAL REVENUES $15.50-$16.15 $2,100-$2,180 3 $ in millions PER DILUTED SHARE $1,891 $13.70 $1,619 $11.04 $1,488 $10.14 $1,325 $9.45 $1,173 $7.93 2 4 2014 2015 2016 2017 2018 2019G 2014 2015 2016 2017

2018 2019G 1 2 2014 to 2018 audited. G=Guidance. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that, for the year ended December 31, 2019, reported total revenues will 3 meet the guidance range

provided on November 5, 2019. Jazz Pharmaceuticals has not finalized its financial results for the year ended December 31, 2019 and actual results may differ. Reconciliations of GAAP net 4 income to non-GAAP adjusted net income can be found in the

Appendix at the end of this presentation. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. Jazz Pharmaceuticals plc is not confirming that guidance and actual results may differ. 9 38th Annual J.P. Morgan Healthcare

Conference January 13, 2020Strong Financial Execution CONSISTENTLY DELIVERING MORE THAN 40% OF REVENUES TO THE BOTTOM LINE 1 ADJUSTED NET INCOME TOTAL REVENUES $15.50-$16.15 $2,100-$2,180 3 $ in millions PER DILUTED SHARE $1,891 $13.70 $1,619 $11.04

$1,488 $10.14 $1,325 $9.45 $1,173 $7.93 2 4 2014 2015 2016 2017 2018 2019G 2014 2015 2016 2017 2018 2019G 1 2 2014 to 2018 audited. G=Guidance. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. The company expects that,

for the year ended December 31, 2019, reported total revenues will 3 meet the guidance range provided on November 5, 2019. Jazz Pharmaceuticals has not finalized its financial results for the year ended December 31, 2019 and actual results may

differ. Reconciliations of GAAP net 4 income to non-GAAP adjusted net income can be found in the Appendix at the end of this presentation. Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. Jazz Pharmaceuticals plc is not

confirming that guidance and actual results may differ. 9 38th Annual J.P. Morgan Healthcare Conference January 13, 2020

While Growing Our Commitment to R&D FOCUS ON DIVERSIFICATION OF

PORTFOLIO LEADING TO EXPANDED INVESTMENT 1 1 TOTAL R&D SPEND R&D SPEND AS % OF TOTAL REVENUES $ in millions 11-13% $245-$265 10% 10% 10% $197 $162 7% $147 6% $97 $72 2 2 2014 2015 2016 2017 2018 2019G 2014 2015 2016 2017 2018 2019G 1

Non-GAAP adjusted R&D spend, unaudited. Reconciliations of GAAP to non-GAAP can be found in the Appendix at the end of this presentation. 2 G=Guidance; Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. Jazz

Pharmaceuticals plc is not confirming or updating that guidance and actual results may differ. 10 38th Annual J.P. Morgan Healthcare Conference January 13, 2020While Growing Our Commitment to R&D FOCUS ON DIVERSIFICATION OF PORTFOLIO LEADING TO

EXPANDED INVESTMENT 1 1 TOTAL R&D SPEND R&D SPEND AS % OF TOTAL REVENUES $ in millions 11-13% $245-$265 10% 10% 10% $197 $162 7% $147 6% $97 $72 2 2 2014 2015 2016 2017 2018 2019G 2014 2015 2016 2017 2018 2019G 1 Non-GAAP adjusted R&D

spend, unaudited. Reconciliations of GAAP to non-GAAP can be found in the Appendix at the end of this presentation. 2 G=Guidance; Guidance provided by Jazz Pharmaceuticals plc on and as of November 5, 2019. Jazz Pharmaceuticals plc is not confirming

or updating that guidance and actual results may differ. 10 38th Annual J.P. Morgan Healthcare Conference January 13, 2020

Non-GAAP Financial Measures To supplement Jazz Pharmaceuticals'

financial results and guidance presented in accordance with GAAP, the company uses certain non-GAAP (also referred to as adjusted or non-GAAP adjusted) financial measures in this presentation and the accompanying tables. In particular, the company

presents non-GAAP adjusted net income (and the related per share measure) and its line item components, as well as certain non-GAAP adjusted financial measures derived therefrom, including non-GAAP adjusted gross margin percentage, non-GAAP adjusted

operating income margin percentage and non-GAAP adjusted effective tax rate. Non-GAAP adjusted net income (and the related per share measure) and its line item components exclude from reported GAAP net income (and the related per share measure) and

its line item components certain items, as detailed in the reconciliation tables that follow, and in the case of non-GAAP adjusted net income (and the related per share measure), adjust for the income tax effect of non-GAAP adjustments and, as

applicable, the income tax benefit related to an intra-entity intellectual property asset transfer and the benefit of the U.S. Tax Cuts and Job Act (U.S. Tax Act). In this regard, the components of non-GAAP adjusted net income, including non-GAAP

cost of product sales, non-GAAP selling, general and administrative expenses and non-GAAP research and development expenses, are income statement line items prepared on the same basis as, and therefore components of, the overall non-GAAP adjusted