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Jaguar Health Reports Approval of All Proposals at August 2025 Annual Meeting of Stockholders Jaguar CEO Lisa Conte presenting August 20 at Emerging Growth Conference to provide updates on near-term catalysts; Click here

Key Takeaway: Jaguar Health, Inc. reported that all proposals were approved during its Annual Meeting of Stockholders on August 19, 2025. The meeting underscored positive developments, including promising initial results from ongoing clinical trials of crofelemer for patients with microvillus inclusion disease and short bowel syndrome. The company is advancing its regulatory strategy for a supplemental NDA to treat metastatic breast cancer in an orphan population. Jaguar's strategy also includes seeking partnerships to develop orphan indication products, which could bolster funding efforts.

Market Sentiment Analysis

POSITIVE FACTORS

  • Approval of all proposals at the Annual Meeting indicates strong governance support.
  • Encouraging proof-of-concept results for crofelemer in treating MVID and SBS-IF.
  • Strategic regulatory pathway planned for supplemental NDA to support breast cancer treatment.
  • Partnerships for orphan products may provide non-dilutive funding opportunities.

Full Press Release Details

Jaguar Health Reports Approval of All Proposals at August 2025 Annual Meeting of Stockholders
Jaguar CEO Lisa Conte presenting August 20 at Emerging Growth Conference to provide updates on near-term catalysts; Click here to
As announced, initial proof-of-concept
results from the ongoing investigator-initiated trial in Abu Dhabi show crofelemer reduced the required total parenteral nutrition in the first participating microvillus inclusion disease (MVID) patient by up to 27% and in the first participating
short bowel syndrome (SBS-IF) patient by up to 12.5%; FDA meeting resulted in planned Jaguar regulatory pathway to complete supplemental NDA strategy for crofelemer for patients with metastatic breast cancer,
a population meeting orphan definition in US
Company strategy: Seek business development partnerships for license to develop and
commercialize Jaguar's orphan indication products, resulting in non-dilutive funding for Jaguar
Francisco, CA (August 19, 2025): Jaguar Health, Inc. (NASDAQ: JAGX) ("Jaguar" or the "Company") today announced the voting results of the Company's Annual Meeting of Stockholders held on August 19, 2025 (the
Seven proposals were submitted to and approved by the stockholders of the Company at the Annual Meeting. The proposals are
described in detail in the Company's definitive proxy statement on Schedule 14A relating to the Annual Meeting and supplemental information filed with the Securities and Exchange Commission on July 21, 2025 and as amended on
August 6, 2025. Stockholders may obtain a free copy of the proxy statement and other documents filed by Jaguar with the SEC at http://www.sec.gov. The proxy statement is also available on the Company's corporate website.
About the Jaguar Health Family of Companies
Health, Inc. (Jaguar) is a commercial stage pharmaceuticals company focused on developing novel proprietary prescription medicines sustainably derived from plants from rainforest areas for people and animals with gastrointestinal distress,
specifically associated with overactive bowel, which includes symptoms such as chronic debilitating diarrhea, urgency, bowel incontinence, and cramping pain. Jaguar family company Napo Pharmaceuticals (Napo) focuses on developing and commercializing
human prescription pharmaceuticals for essential supportive care and management of neglected gastrointestinal symptoms across multiple complicated disease states. Napo's crofelemer is FDA-approved under
the brand name Mytesi for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy. Jaguar family company Napo Therapeutics is an Italian corporation
Jaguar established in Milan, Italy in 2021 focused on expanding crofelemer access in Europe and specifically for orphan diseases. Jaguar Animal Health is a Jaguar tradename. Magdalena Biosciences, a joint venture formed by Jaguar and Filament Health
Corp. that emerged from Jaguar's Entheogen Therapeutics Initiative (ETI), is focused on developing novel prescription medicines derived from plants for mental health indications.
For more information about:
Jaguar Health, visit
Napo Pharmaceuticals, visit www.napopharma.com
Napo Therapeutics, visit napotherapeutics.com
Biosciences, visit magdalenabiosciences.com
Canalevia-CA1, visit canalevia.com
Visit the Make Cancer Less Shitty patient advocacy program on Bluesky, X, Facebook &
Forward-Looking Statements
statements in this press release constitute "forward-looking statements." These include statements regarding Jaguar's expectation that Jaguar management will present at the August 2025 Emerging Growth Conference, and statements
regarding Jaguar's planned regulatory pathway to complete a supplemental NDA for crofelemer for patients with metastatic breast cancer. In some cases, you can identify forward-looking statements by terms such as "may,"
"will," "should," "expect," "plan," "aim," "anticipate," "could," "intend," "target," "project," "contemplate,"
"believe," "estimate," "predict," "potential" or "continue" or the negative of these terms or other similar expressions. The forward-looking statements in this release are only predictions.
Jaguar has based these forward-looking statements largely on its current expectations and projections about future events. These forward-looking statements speak only as of the date of this release and are subject to several risks, uncertainties,
and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar's control. Except as required by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained
herein, whether as a result of any new information, future events, changed circumstances or otherwise.
Source: Jaguar Health, Inc.

Frequently Asked Questions

What proposals were approved at Jaguar's Annual Meeting?

Seven proposals were submitted and approved by Jaguar stockholders.

What is crofelemer used for?

Crofelemer provides symptomatic relief for noninfectious diarrhea in adults with HIV/AIDS.

What is Jaguar Health's main focus?

Jaguar develops novel medicines for gastrointestinal distress in humans and animals.

How much did crofelemer reduce parenteral nutrition in trials?

Crofelemer reduced total parenteral nutrition by 27% in MVID and 12.5% in SBS-IF.

What is Jaguar's strategy for orphan indication products?

Jaguar seeks partnerships for licensing and non-dilutive funding for its products.

Last updated: Aug 19, 2025