Jaguar Health and its Subsidiary, Napo Pharmaceuticals, Enter an Amendment to the Accounts Receivable Purchase Agreement with Oasis Capital

Health and its Subsidiary, Napo Pharmaceuticals, Enter an

Amendment to the Accounts Receivable Purchase Agreement with

Oasis Capital, LLC, Dated May 12, 2020

Additional spring 2020 sales of Mytesi

(beyond April 2020 sales) generate gross accounts receivable of $2,859,132

SAN FRANCISCO, CA / June 29, 2020 / Jaguar Health, Inc.

(NASDAQ:JAGX) today announced that Jaguar and its wholly owned subsidiary, Napo Pharmaceuticals, Inc., (collectively, the "Company")

have jointly entered into an amendment to the accounts receivable purchase agreement with Oasis Capital, LLC ("Oasis"),

dated May 12, 2020, pursuant to which Oasis agreed to purchase additional accounts receivable of the Company related to the sales

of the Company's Mytesi drug product to Cardinal Health for the period of May 2020 through June 24, 2020 (the "Spring

2020 Accounts Receivable"). The Spring 2020 Accounts Receivable have a gross value of $2,859,132.

"We are pleased to enter into this amendment with Oasis.

Based on the success of the first tranche of accounts receivable financing we are able to further our strategy of bringing in non-dilutive

capital and striving to become a stable, cash flow positive commercial business," said Lisa Conte, Jaguar's president and

Per the terms of the agreement, Oasis will receive a fee of

5.45% (the "Fee") of the $2,859,132 Spring 2020 Accounts Receivable following their purchase of the Spring 2020 Accounts

Receivable for $1,215,131, an increased percentage of the gross accounts receivable compared to the April 2020 purchase (the "Purchase

Price"). As with the April 2020 sales of Mytesi, Oasis will return to the Company any amount that exceeds the sum of the Purchase

Price and the Fee. As with all Mytesi gross sales, the Spring 2020 Accounts Receivable will be reduced by Medicare, ADAP 340B chargebacks,

returns, and wholesale distribution fees based on historical trends to determine net sales.

Under the amendment, Oasis is entitled to a one-time transaction

About Jaguar Health, Inc.

Jaguar Health, Inc. is a commercial stage pharmaceuticals company

focused on developing novel, plant-based, sustainably derived gastrointestinal products on a global basis. Our wholly owned subsidiary,

Napo Pharmaceuticals, Inc., focuses on developing and commercializing proprietary plant-based human gastrointestinal pharmaceuticals

for the global marketplace from plants used traditionally in rainforest areas. Our Mytesi (crofelemer) product

is approved by the U.S. FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy

and the only oral plant-based prescription medicine approved under FDA Botanical Guidance.

For more information about Jaguar, please visit https://jaguar.health.

For more information about Napo, visit napopharma.com.

Mytesi (crofelemer) is an antidiarrheal indicated for the

symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi is not

indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi. If

infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the

appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate

greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and

increased bilirubin (3.1%).

See full Prescribing Information at Mytesi.com. Crofelemer,

the active ingredient in Mytesi, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal

Croton lechleri tree in the Amazon Rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure

a high degree of quality and ecological integrity.

Forward-Looking Statements

Certain statements in this press release constitute "forward-looking

statements." In some cases, you can identify forward-looking statements by terms such as "may," "will,"

"should," "expect," "plan," "aim," "anticipate," "could,"

"intend," "target," "project," "contemplate," "believe," "estimate,"

"predict," "potential" or "continue" or the negative of these terms or other similar expressions.

The forward-looking statements in this release are only predictions. Jaguar has based these forward-looking statements largely

on its current expectations and projections about future events. These forward-looking statements speak only as of the date of

this release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified

and some of which are beyond Jaguar's control. Except as required by applicable law, Jaguar does not plan to publicly update

or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances

Source: Jaguar Health, Inc.