Document Evolus Reports Fourth Quarter and Full-Year 2021 Results and Provides Business Update Q4 2021 Net Revenue of $34.7 Million, Up 68% from Q4 2020 Full-Year 2021 Net Revenue of $99.7 Million, Up 76% Over 2020 Full-

Evolus Reports Fourth Quarter

and Full-Year 2021 Results and Provides Business Update

Q4 2021 Net Revenue of $34.7 Million, Up 68% from Q4 2020

Full-Year 2021 Net Revenue of $99.7 Million, Up 76% Over 2020

Full-Year 2022 Net Revenue Guidance of $143 to $150 Million Reaffirmed

Cash Position at December 31, 2021 of $146.3 Million

NEWPORT BEACH, Calif., March 3, 2022 - Evolus, Inc. (NASDAQ EOLS), a performance beauty company with a customer-centric approach focused on delivering breakthrough products, today reported financial results for the fourth quarter and full-year ended December 31, 2021 and provided a business update. The results were consistent with the previously reported preliminary unaudited results announced on January 26, 2022.

"We are very pleased to announce record fourth quarter 2021 sales of Jeuveau , which reflected accelerating growth trends," said David Moatazedi, President and Chief Executive Officer. "For the full year, we achieved net revenue growth of 76%. Our strong results were driven by our singularity in focus targeting Jeuveau to millennial consumers, the fastest-growing segment of neurotoxin users, through our first in class co-branded marketing program."

Evolus finished 2021 achieving all-time highs across several key metrics

Evolus added 400 new customer accounts in the fourth quarter and 1,400 new accounts in 2021, bringing the total accounts purchasing since launch to more than 7,000 with a reorder rate of over 70%1.

During the year, Evolus ran more than 2,300 individualized co-branded marketing campaigns across the United States resulting in more than 1 billion impressions for the year. This is more than 4-times the number of campaigns that were run in 2020 and 20-times the number of impressions.

Since inception, more than 270,000 consumers have registered in the Evolus Rewards loyalty program2, more than double the level a year ago, and the program has provided consumers over 120,000 repeat treatments of Jeuveau .

Moatazedi continued, "Our strong exit to the year along with favorable underlying trends in the aesthetic neurotoxin market positions us for continued growth and share gains in 2022. As such, we remain confident in our 2022 net revenue guidance of $143 million to $150 million, which equates to 43% to 50% growth over 2021, a rate more than double the industry average."

Fourth Quarter 2021 Business Highlights and Recent Developments

During the quarter, the company entered into a $125 million term loan financing facility and borrowed the first tranche of $75 million. This first tranche is expected to fund Evolus through cash flow breakeven, removing the need for any further financing of its current operations. The company also has $50 million available under the second tranche of the facility that can be drawn without restriction prior to December 31, 2022.

The company continues to make progress on its Phase II "extra strength" Jeuveau clinical study and remains on track to enroll its first patient during the first quarter of 2022.

In January 2022, the company further strengthened and diversified its Board of Directors with the appointment of digital and beauty innovator Brady Stewart.

In February 2022, the company's submission to the Australian Therapeutics Good Administration for regulatory approval of Nuceiva was accepted, an important milestone toward its international growth strategy.

Fourth Quarter 2021 Financial Results

Total net revenues in the fourth quarter of 2021 increased 68% to $34.7 million from $20.6 million in the fourth quarter of 2020 driven by both higher volumes and a higher average selling price.

Gross profit margin and adjusted gross profit margin were 52.2% and 54.3%, respectively, both of which were impacted by the higher settlement royalty rates in effect until September 2022. Adjusted gross profit margin excludes amortization of intangibles.

Operating expenses decreased 59% to $52.7 million from $128.6 million in the fourth quarter of 2020. Non-GAAP operating expenses increased to $31.1 million from $25.5 million in the fourth quarter of 2020. Non-GAAP operating expenses exclude product cost of sales, revaluation of the contingent royalty obligation expense, stock-based compensation expense, settlement payments and expenses, and depreciation and amortization expense.

Loss from operations decreased 83% to $18.0 million from $108.0 million in the fourth quarter of 2020, which included $83.4 million of litigation settlement expenses. Non-GAAP loss from operations was $12.2 million in the fourth quarter of 2021 and was impacted by the payment of settlement royalties. Non-GAAP loss from operations excludes product cost of sales, revaluation of the contingent royalty obligation expense, stock-based compensation expense, settlement payments and expenses, and depreciation and amortization expense.

Full-Year 2021 Financial Results

Total net revenues for 2021 increased 76% to $99.7 million from $56.5 million for 2020.

Gross profit margin and adjusted gross profit margin were 79.0% and 56.3%, respectively, both of which were impacted by the higher settlement royalty rates in effect until September 2022. Adjusted gross profit margin, which excluded amortization of intangibles and a $25.5 million settlement payment from Daewoong, was at the high end of company guidance.

Operating expenses decreased 31% to $144.1 million from $209.6 million in 2020. Non-GAAP operating expenses increased 13% to $104.6 million from $92.3 million in 2020. Non-GAAP operating expenses exclude product cost of sales, revaluation of the contingent royalty obligation expense, stock-based compensation expense, settlement payments and expenses, and depreciation and amortization expense.

Loss from operations decreased 71% to $44.4 million from $153.1 million in 2020. Non-GAAP loss from operations decreased by 10% to $48.4 million from $54.0 million in 2020. Non-GAAP loss from operations excludes product cost of sales, revaluation of the contingent royalty obligation expense, stock-based compensation expense, settlement payments and expenses, and depreciation and amortization expense.

Cash and cash equivalents as of December 31, 2021 were $146.3 million, including borrowings, net of discounts and issuance costs, of $68.7 million from the first tranche of the credit facility with Pharmakon.

Net cash used in operating activities decreased by 42% to $33.4 million in 2021 from $57.9 million in 2020.

The company continues to expect total net revenues for full-year 2022 to be between $143 million and $150 million, representing strong year-over-year growth of 43% to 50%. This assumes a minimal sales contribution from international markets.

The company expects its adjusted gross profit margin for the full year 2022 to be between 58% and 61%. Settlement royalty rates will decrease significantly in September 2022, which is expected to lift the adjusted gross profit margin to be between 68% to 71% for the fourth quarter of 2022.

Non-GAAP operating expenses for 2022 are estimated to be between $135 million and $140 million, which consists mainly of continued investments in the growth of Jeuveau in the U.S. plus Nuceiva launch expenses in Europe. Non-GAAP operating expenses exclude product cost of sales, revaluation of the contingent royalty obligation expense, stock-based compensation expense, and depreciation and amortization expense.

During the first quarter of 2022, the company expects to make its second lump-sum settlement payment of $15 million under the 2021 settlement agreements. The company will make its final settlement payment of $5 million in the first quarter of 2023.

The company remains on track to commence the launch of Nuceiva in Europe in the third quarter of 2022.

Conference Call Information

Management will host a conference call and live webcast to discuss Evolus' financial results today at 1 30 p.m. ET. To participate in the conference call, dial (877) 407-6184 (U.S.) or (201) 389-0877 (international) or connect to the live webcast via the link on the Investor Relations page of the Evolus website at www.evolus.com.

Following the completion of the call, an audio replay can be accessed for 48 hours by dialing (877) 660-6853 (U.S.) or (201) 612-7415 (international) and using conference number 13726963. An archived webcast, which will remain available for 30 days, can also be accessed on the Investor Relations page of the Evolus website at www.evolus.com.

Forward-Looking Statements

This press release contains forward-looking statements as defined under the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including statements that relate to the status of regulatory processes,

future plans, events, prospects or performance and statements containing the words "plans," "expects," "believes," "strategy," "opportunity," "anticipates," "outlook," "designed," or other forms of these words or similar expressions, although not all forward-looking statements contain these identifying words. The company's forward-looking statements include, but are not limited to, statements related to the company's prospects, strategy, the company's financial outlook for 2022 and expectations regarding financing plans, clinical study enrollment, regulatory approvals and international commercial product launches.

Forward-looking statements involve risks and uncertainties that could cause actual results or experiences to differ materially from those expressed or implied by the forward-looking statements. Factors that could cause actual results or experience to differ materially from that expressed or implied by the forward-looking statements include uncertainties associated with our ability to address all of our losses, costs, expenses, liabilities and damages resulting from the settlement agreement with Daewoong and our ability to comply with the terms and conditions in the Allergan Medytox Settlement Agreements, the continued impact of COVID-19 on our business and the economy generally, uncertainties related to customer and consumer adoption of Jeuveau , the efficiency and operability of our digital platform, competition and market dynamics, and our ability to maintain regulatory approval of Jeuveau and other risks described in Evolus' filings with the Securities and Exchange Commission, including in the section entitled "Risk Factors" in our Quarterly Report on Form 10-Q for the quarter ended September 30, 2021 that was filed with the Securities and Exchange Commission on November 2, 2021. These filings can be accessed online at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by law, Evolus undertakes no obligation to update or revise any forward-looking statements to reflect new information, changed circumstances or unanticipated events. If the company does update or revise one or more of these statements, investors and others should not conclude that the company will make additional updates or corrections.

Use of Non-GAAP Financial Measures

Evolus' financial results are prepared in accordance with accounting principles generally accepted in the United States of America ("GAAP"). This press release and the reconciliation tables included in the financial schedules below include adjusted gross profit, adjusted gross profit margin, non-GAAP operating expenses and non-GAAP loss from operations. Adjusted gross profit is calculated as gross profit excluding amortization of an intangible asset and, as applicable, the one-time settlement payment from Daewoong. Adjusted gross profit margin is defined as adjusted gross profit as a percentage of total net revenues. Non-GAAP operating expenses exclude, as applicable, (i) product cost of sales, (ii) one-time settlement payment from Daewoong, (iii) the revaluation of contingent royalty obligations, (iv) stock-based compensation expense, (v) depreciation and amortization and (vi) litigation settlement expenses. Non-GAAP loss from operations excludes, as applicable, (i) one-time settlement payment from Daewoong, (ii) the revaluation of contingent royalty obligations, (iii) stock-based compensation expense, (iv) depreciation and amortization and (v) litigation settlement expenses. Management believes that adjusted gross profit margin is an important measure for investors because management uses adjusted gross profit margin as a key performance indicator to evaluate the profitability of sales without giving effect to costs that are not core to our cost of sales, such as the settlement payment from Daewoong, and the amortization of an intangible asset. Management believes that non-GAAP operating expenses and non-GAAP loss from operations are useful in helping to identify the company's core operating performance and enables management to consistently analyze the period-to-period financial performance of the core business operations. Management also believes that non-GAAP operating expenses and non-GAAP loss from operations will enable investors to assess the company in the same way that management has historically assessed the company's operating expenses against comparable companies with conventional accounting methodologies. The company's definitions of adjusted gross profit, adjusted gross profit margin, non-GAAP operating expenses and non-GAAP loss from operations have limitations as analytical tools and may differ from other companies reporting similarly named measures. Non-GAAP measures should not be considered measures of financial performance under GAAP, and the items excluded from such non-GAAP measures should not be considered in isolation or as alternatives to financial statement

data presented in the financial statements as an indicator of financial performance or liquidity. Non-GAAP measures should be considered in addition to results prepared in accordance with GAAP but should not be considered a substitute for or superior to GAAP results.

For a reconciliation of our historical adjusted gross profit margin, non-GAAP operating expenses and non-GAAP loss from operations presented herein to gross profit margin, GAAP operating expenses and GAAP loss from operations, the most directly comparable GAAP financial measures, please see "Reconciliation of Gross Profit Margin to Adjusted Gross Profit Margin," "Reconciliation of GAAP Operating Expenses to Non-GAAP Operating Expenses" and "Reconciliation of GAAP Loss from Operations to Non-GAAP Loss from Operations" in the financial schedules below. In addition, this press release includes information regarding the company's expected adjusted gross profit margin and non-GAAP operating expenses for full year 2022. Evolus has not provided a reconciliation of such forward-looking non-GAAP adjusted gross profit margin or non-GAAP operating expenses because a reconciliation of such measures to GAAP gross profit margin and GAAP operating expenses, respectively, the most directly comparable GAAP financial measures, is not available without unreasonable efforts. This is due to the inherent difficulty of forecasting the timing or amount of various reconciling items that would impact the forward-looking adjusted gross profit and non-GAAP operating expenses outlook that have not yet occurred and or cannot be reasonably predicted. Such unavailable information could have a significant impact on Evolus' GAAP financial results.

Jeuveau and Nuceiva are registered trademarks of Evolus, Inc.

Hi-Pure is a trademark of Daewoong Pharmaceutical Co, Ltd.

1 Represents cumulative statistics from the launch of Jeuveau in May 2019 through December 31, 2021.

2 Represents cumulative statistics from the launch of Evolus Rewards in May 2020 through December 31, 2021.

Investor Media Contact

David K. Erickson, Evolus, Inc.

Vice President, Investor Relations

Email david.erickson evolus.com

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