Full Press Release Details
BOSTON, Nov. 04, 2025 (GLOBE NEWSWIRE) -- Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics, today announced its poster presentation at the 40thSociety for Immunotherapy of Cancer (SITC) Annual Meeting, taking place November 5-9, 2025, in National Harbor, MD.
Details of the presentation are as follows:
Title:Preclinical Development of CTX-10726, a Tetravalent Bispecific Antibody Targeting PD-1 and VEGF-A for the Treatment of Patients with CancerPresenter:Diana Albu, PhD; Compass TherapeuticsDate & Time:November 7, 2025, from 12:15 PM-1:45 PM and 5:35-7:00 PMAbstract number:1151Location:Gaylord National Resort & Convention Center – Exhibit Halls AB
Data highlights from the poster presentation include:
A copy of the presentation materials can be accessed on the Compass website athttps://www.compasstherapeutics.com/pipeline/once the presentation has concluded.
About CTX-10726CTX-10726 is a bispecific, tetravalent antibody that simultaneously targets vascular endothelial growth factor (VEGF)-A and programmed cell death (PD)-1. CTX-10726 is being developed for the treatment of patients with metastatic or locally advanced tumor types where clinical checkpoint and angiogenesis signals are present. Checkpoint inhibitor antibody therapies targeting PD-1 and PD-L1 as well as agents targeting tumor angiogenesis have shown great success for the treatment of various malignancies. However, a substantial fraction of patients with PD-(L)1-positive tumors remain unresponsive to these therapies. CTX-10726 is believed to enhance anti-tumor response by both targeting immune checkpoints and tumor vasculature and has shown potent anti-tumor activity in preclinical mouse models. Currently, CTX-10726 is being tested in IND-enabling studies.
About Compass TherapeuticsCompass Therapeutics, Inc. is a clinical-stage oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases. The company’s scientific focus is on the relationship between angiogenesis, the immune system, and tumor growth. Compass has built a robust pipeline of novel product candidates designed to target multiple critical biological pathways required for an effective anti-tumor response. These include modulation of the microvasculature via angiogenesis-targeted agents, induction of a potent immune response via activators on effector cells in the tumor microenvironment, and alleviation of immunosuppressive mechanisms used by tumors to evade immune surveillance. The company plans to advance its product candidates through clinical development as both standalone therapies and in combination with proprietary pipeline antibodies based on supportive clinical and nonclinical data. The Company was founded in 2014 and is headquartered in Boston, Massachusetts.
Forward-Looking Statements
This press release contains forward-looking statements. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, statements regarding Compass’s product candidates, including the therapeutic potential of CTX-10726. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, Compass’s ability to raise the additional funding it will need to continue to pursue its business and product development plans, the inherent uncertainties associated with developing product candidates and operating as a development stage company, Compass’s ability to identify additional product candidates for development, Compass’s ability to develop, complete clinical trials for, obtain approvals for and commercialize any of its product candidates, competition in the industry in which Compass operates and market conditions. These forward-looking statements are made as of the date of this press release, and Compass assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents Compass files with the U.S. Securities and Exchange Commission (SEC) available atwww.sec.gov, including without limitation Compass’s latest Annual Report on Form 10-K and subsequent filings with the SEC.