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Compass Pathways’ New 52-Week Topline Open-Label Data from Phase 3 COMP005 Trial Demonstrates Additional Benefit from Another COMP360 Dose in Part C Extending Durability Out to 1 Year

Key Takeaway: Compass Pathways has released topline results from the Phase 3 COMP005 trial of COMP360, a psilocybin formulation for treatment-resistant depression. The open-label Part C data indicates an additional benefit from another dose, extending the treatment's durability to one year. This supports the drug's differentiated profile and potential for long-term effectiveness.

Market Sentiment Analysis

POSITIVE FACTORS

  • Topline data shows additional benefit from COMP360 dose.
  • Results support COMP360's differentiated profile.
  • Demonstrated potential for long-lasting benefits in TRD.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~32 mo
Minimal dilution risk
Lead asset
Psilocybin
Phase 3 · Major Depressive Disorder

Full Press Release Details

LONDON & NEW YORK--(BUSINESS WIRE)---- $CMPS #Biotech--Compass Pathways plc (Nasdaq: CMPS), a biotechnology company dedicated to unlocking urgently needed new treatment options in mental health care, announced today the topline 52-week results (Part C) from its Phase 3 COMP005 trial of COMP360, a synthetic, proprietary formulation of psilocybin, for treatment-resistant depression (TRD) which further support COMP360’s differentiated profile and potential for long lasting benefit. The open-label Part C data demonst

Frequently Asked Questions

What is COMP360?

COMP360 is a synthetic, proprietary formulation of psilocybin developed for treatment-resistant depression.

What were the results of the Phase 3 COMP005 trial?

The topline results indicated an additional benefit from another COMP360 dose, extending treatment durability to one year.

What is the significance of the Part C data?

Part C data supports COMP360's differentiated profile and potential for long-lasting benefits.

Who is Compass Pathways?

Compass Pathways is a biotechnology company focused on developing new treatment options in mental health care.

Last updated: Sep 9, 2026