Cognition Therapeutics Reports Year End 2021 Financial Results and Provides Business Update - Well capitalized from $52 million IPO and $169 million in grant funding - - Established clinical program in Alzheimer's diseas

Cognition Therapeutics Reports Year End 2021

Financial Results and Provides

- Well capitalized from $52 million IPO and

$169 million in grant funding -

- Established clinical program in Alzheimer's

disease enhanced by new DLB study and dry AMD program

- Conference Call and Live Audio Webcast Scheduled

for Wednesday, March 30 at 8:00 a.m. ET -

March 30, 2022 (GLOBE NEWSWIRE) - Cognition Therapeutics, Inc. (NASDAQ: CGTX), a clinical-stage

biopharmaceutical company engaged in the discovery and development of innovative, small molecule therapeutics targeting age-related degenerative

diseases and disorders of the central nervous system and retina (the "Company" or "Cognition"), today reported

financial results for the year ended December 31, 2021 and provided recent business updates.

upsized initial public offering (IPO) in October 2021 supplemented our non-dilutive grant funding, which we believe provides us

with a strong balance sheet," stated Lisa Ricciardi, president and CEO of Cognition Therapeutics. "With that foundation,

we have made progress advancing our clinical programs in Alzheimer's disease and dementia with Lewy bodies (DLB). We

anticipate starting a dry age-related macular degeneration (dry AMD) Phase 2 clinical study in the second half of 2022. In addition,

we will be starting our study in early-stage Alzheimer's disease with our partners, the ACTC, in the second half of 2022. To

support these clinical programs and our critical pipeline and biomarker discovery efforts, we have strengthened our team with

several key appointments in clinical operations, finance, and R&D, including Anthony Caggiano, M.D., Ph.D. as Chief Medical

Officer and Head of R&D. We believe these strategic hires allow us to aggressively pursue our goals."

we were awarded by the National Institute of Aging (NIA) and MJFF to support our research into treatments for synucleinopathies including

DLB and Parkinson's disease are valuable sources of non-dilutive funding, and we believe offer validation of our scientific approach

from these well-respected organizations," added Ms. Ricciardi. "Working closely with our colleagues at the Lewy Body

Dementia Association (LBDA), we have made progress onboarding clinical trial sites for our study of CT1812 in DLB and look forward to

treating the first patients. We are grateful to the NIA for their support of this study and for our other ongoing trials."

Financial Highlights:

Cognition Therapeutics, Inc.

2021 Financial Results

Conference Call Information

host a conference call and live webcast to discuss Cognition's financial results today at 8:00 a.m. ET. To participate in

the conference call, dial (844) 467-7752 (U.S.) or (270) 215-9364 (international) and provide conference ID number 7048915. Alternatively,

you may connect to the live webcast via the link on the Investor Relations page of the Cognition website at www.cogrx.com.

The archived webcast will be available for 90

days beginning at approximately 9:30 a.m. ET, on Wednesday, March 30, 2022.

About Cognition Therapeutics. Inc.

Cognition Therapeutics, Inc. is a clinical-stage

biopharmaceutical company engaged in the discovery and development of innovative, small molecule therapeutics targeting age-related degenerative

diseases and disorders of the central nervous system, or CNS, and retina. Our goal is to develop disease modifying treatments for patients

with these degenerative disorders by initially leveraging our expertise in the -2 (sigma-2) receptor, or S2R, which is expressed

by multiple cell types, including neuronal synapses, and acts as a key regulator of cellular damage commonly associated with certain age-related

degenerative diseases of the CNS and retina. We believe that targeting the S2R complex represents a mechanism that is functionally distinct

from other current approaches in clinical development for the treatment of degenerative diseases.

Cognition Therapeutics, Inc.

Forward-looking Statements

press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements

contained in this press release, other than statements of historical facts or statements that relate to present facts or current conditions,

including but not limited to, statements regarding our cash and financial resources and our clinical development plans, are forward-looking

statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results,

performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by

the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as "may," "might,"

"will," "should," "expect," "plan," "aim," "seek," "anticipate,"

"could," "intend," "target," "project," "contemplate," "believe,"

"estimate," "predict," "forecast," "potential" or "continue" or the negative

of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections

about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These

forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions,

some of which cannot be predicted or quantified and some of which are beyond our control. Factors that may cause actual results to differ

materially from current expectations include, but are not limited to: competition, our ability to grow and manage growth, maintain relationships

with suppliers and retain our management and key employees; our ability to successfully advance our current and future product candidates

through development activities, preclinical studies and clinical trials and costs related thereto; the timing, scope and likelihood of

regulatory filings and approvals, including final regulatory approval of our product candidates; changes in applicable laws or regulations;

the possibility that the we may be adversely affected by other economic, business or competitive factors; our estimates of expenses and

profitability; the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate

our existing products; our ability to defend our intellectual property; the impact of the COVID-19 pandemic on our business, supply chain

and labor force; and the risks and uncertainties described in the "Risk Factors" section of our most recent filings with

the Securities and Exchange Commission, available at www.sec.gov. You should not rely on these forward-looking statements

as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur,

and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic

industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict

all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise

any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or

Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc.

Unaudited Selected Financial Data

Cognition Therapeutics, Inc.

For more information contact:

Cognition Therapeutics, Inc.

Aline Sherwood (media)

Scienta Communications

Lisa Sher/Daniel Kontoh-Boateng (investors)

Tiberend Strategic Advisors, Inc.

lsher@tiberend.com; dboateng@tiberend.com

Cognition Therapeutics, Inc.