Cognition Therapeutics Reports Financial Results for the Second Quarter 2025 and Highlights Progress Across Clinical Programs - Discussed plans to support a pivotal Alzheimer's disease program with FDA at end-of-phase 2

Cognition Therapeutics Reports Financial Results

for the Second Quarter 2025

and Highlights Progress Across Clinical Programs

- Discussed plans to support a pivotal Alzheimer's

disease program with FDA at end-of-phase 2 meeting -

- Initiated expanded access program (EAP) for

people with dementia with Lewy bodies (DLB) -

- Surpassed 50% enrollment in Phase 2 START'

study of zervimesine in early Alzheimer's disease -

Purchase, NY - August 7, 2025 - Cognition Therapeutics,

Inc. (the "Company" or "Cognition") (NASDAQ: CGTX), a clinical-stage company developing drugs that treat

neurodegenerative disorders, today reported financial results for the second quarter ended June 30, 2025, and provided a business update.

"The second quarter of 2025 has been very productive, with milestones

from each of our clinical programs," stated Lisa Ricciardi, Cognition's president and CEO. "These accomplishments

highlight the potential for zervimesine to slow the progression of age-related degenerative diseases such as Alzheimer's disease,

dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). The clinical findings from each program have been

supplemented by the publication of proteomic analyses and in vitro studies that support the mechanism of action of zervimesine

in these patient populations."

Business and Corporate Highlights

"Later this month we anticipate receiving the FDA's minutes

from our end-of-Phase 2 meeting regarding registrational plans for zervimesine in Alzheimer's disease. We expect these will confirm

our understanding of the Agency's expectations for a clinical program in Alzheimer's disease," added Ms. Ricciardi. "In

addition, we expect FDA will have a decision on breakthrough designation for zervimesine in DLB in the third quarter 2025. We expect

these milestones will be valuable to potential partners as we continue to evaluate our options to support development of zervimesine."

Cognition Therapeutics, Inc.

Second Quarter 2025 Financial Results

Cash, cash equivalents, and restricted cash equivalents as of June

30, 2025 were approximately $11.6 million and total obligated grant funds remaining from the National Institute of Aging, a division of

the National Institute of Health were $41.9 million. The Company estimates that it has sufficient cash to fund operations and capital

expenditures into the second quarter of 2026.

Research and development expenses were $11.5 million for the quarter

ended June 30, 2025, compared to $11.6 million for the comparable period in 2024. The change in research and development expenses was

primarily driven by a decrease in professional fees.

General and administrative expenses were $2.5 million for the quarter

ended June 30, 2025, compared to $3.1 million for the comparable period in 2024. The change in general and administrative expenses was

driven primarily by reduced stock-based compensation expenses.

The Company reported a net loss of $6.7 million, or $(0.11) per basic

and diluted share for the quarter ended June 30, 2025, compared to a net loss of $7.0 million, or $(0.18) per basic and diluted share

for the same period in 2024.

About Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc., is a clinical-stage biopharmaceutical

company discovering and developing innovative, small molecule therapeutics targeting age-related degenerative disorders of the central

nervous system. We recently completed Phase 2 studies of our lead candidate, zervimesine (CT1812) in dementia with Lewy bodies (DLB),

mild-to-moderate Alzheimer's disease and geographic atrophy secondary to dry AMD. The Phase 2 START study (NCT05531656)

in early Alzheimer's disease is ongoing with $81 million in grant support from the National Institute of Aging (NIA) at the National

Institutes of Health. We believe zervimesine can regulate pathways that are impaired in these diseases though its interaction with the

sigma-2 receptor, a mechanism that is functionally distinct from other approaches for the treatment of degenerative diseases. More about

Cognition Therapeutics and our pipeline can be found at https://cogrx.com.

Forward-Looking Statements

press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements

contained in this press release or made during the conference call, other than statements of historical facts or statements that relate

to present facts or current conditions, including but not limited to, statements related to our cash runway, our clinical studies of

zervimesine (CT1812), and any analysis of the results therefrom; any expected or implied benefits or results of zervimesine, including

that initial clinical results observed with respect to zervimesine will be replicated in later trials and our clinical development plans,

and our plans for regulatory approval, including our expectations regarding the results and timing of the end-of-Phase 2 meeting for

Alzheimer's disease and the FDA's review of breakthrough designation for zervimesine in DLB, are forward-looking statements.

These statements, including statements relating to the timing and expected results of our clinical trials involve known and unknown risks,

uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different

from any future results, performance, or achievements expressed or implied by the forward-looking statements. In some cases, you can

identify forward-looking statements by terms such as "may," "might," "will," "should,"

"expect," "plan," "aim," "seek," "anticipate," "could," "intend,"

"target," "project," "contemplate," "believe," "estimate," "predict,"

"forecast," "potential" or "continue" or the negative of these terms or other similar expressions.

We have based these forward-looking statements largely on our current expectations and projections about future events and financial

trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak

only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be

predicted or quantified and some of which are beyond our control. Factors that may cause actual results to differ materially from current

expectations include, but are not limited to: competition; our ability to secure new (and retain existing) grant funding; our ability

to grow and manage growth, maintain relationships with suppliers and retain our management and key employees; our ability to successfully

advance our current and future product candidates through development activities, preclinical studies and clinical trials and costs related

thereto; uncertainties inherent in the results of preliminary data, pre-clinical studies and earlier-stage clinical trials being predictive

of the results of early or later-stage clinical trials; the timing, scope and likelihood of regulatory filings and approvals, including

regulatory approval of our product candidates; changes in applicable laws or regulations; the possibility that we may be adversely affected

by other economic, business or competitive factors, including ongoing economic uncertainty; our estimates of expenses and profitability;

the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate our existing

products; our ability to defend our intellectual property; the impacts of global political changes and global economic conditions, supply

chain and labor force; our ability to maintain the listing of our common stock on the Nasdaq Capital Market; and the risks and uncertainties

described more fully in the "Risk Factors" section of our annual and quarterly reports filed with the Securities &

Exchange Commission and are available at www.sec.gov. These risks are not exhaustive and we face both known and unknown risks.

You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our

forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking

statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time,

and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable

law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information,

future events, changed circumstances or otherwise.

Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc.