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Bausch Health Provides Update on RED-C Phase 3 Clinical Trials
LAVAL, QC, January 23, 2026 - Bausch Health Companies Inc. (NYSE BHC)(TSX BHC), today announced the results of the global Phase 3 RED-C clinical program evaluating amorphous-rifaximin solid soluble dispersion (SSD) in adults with liver cirrhosis for the primary prevention of hepatic encephalopathy (HE). While safe and well-tolerated, both clinical trials did not meet the primary endpoint.
"We are disappointed in the results, as there is currently no approved treatment for these patients. We are currently reviewing the full dataset to determine potential new development opportunities," said Thomas J. Appio, Chief Executive Officer, Bausch Health. "We want to thank the patients, families, investigators, and research teams whose participation made this important clinical research possible."
Bausch Health remains committed to bringing new treatments to patients across hepatology and other therapeutic areas.
About the RED-C Program
The RED-C program consists of two global, randomized, double-blind, placebo-controlled Phase 3 trials involving more than 1,000 patients across 398 sites in 17 countries. The clinical trials evaluated rifaximin SSD for the delay of the first episode of hepatic encephalopathy (HE) in adults with liver cirrhosis who had no prior HE episodes.
Cirrhosis is a major cause of end-stage liver disease in the US. Based on October 25, 2024, data from the Centers for Disease Control and Prevention, chronic liver disease and cirrhosis rank ninth as a cause of death. In a patient with cirrhosis, progression is characterized by the development of hepatic encephalopathy (HE), jaundice, clinically significant ascites, or variceal hemorrhage.
Bausch Health Companies Inc. (NYSE BHC)(TSX BHC), is a global, diversified pharmaceutical company enriching lives through our relentless drive to deliver better health care outcomes. We develop, manufacture and market a range of products primarily in gastroenterology, hepatology, neuroscience, dermatology, dentistry, aesthetics, international pharmaceuticals and eye health, through our controlling interest in Bausch + Lomb Corporation. Our ambition is to be a globally integrated healthcare company, trusted and valued by patients, HCPs, employees and investors. For more information about Bausch Health, visit www.bauschhealth.com and connect with us on LinkedIn.
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