For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES i 1. Identity of the issuer or the underlying issuer of existing shares to which voting

Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi Woodford Investment Management LLP as Investment Manager Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13.

Notified details: A: Voting rights attached to shares viii, ix Class/type of shares if possible using the ISIN CODE Situation previous to the triggering transaction Resulting situation after the triggering transaction Number of Shares Number of Voting Rights Number of shares Number of voting rights % of voting rights x Direct Direct xi Indirect xii Direct Indirect GB00BRTL9B63 6,677,899 6,677,899 6,703,189 6,703,189 20% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial instrument Expiration date xiii Exercise/ Conversion Period xiv Number of voting rights that may be acquired if the instrument is exercised/ converted. % of voting rights C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi Resulting situation after the triggering transaction Type of financial instrument Exercise price Expiration date xvii Exercise/ Conversion period xviii Number of voting rights instrument refers to % of voting rights xix, xx Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights 6,703,189 20% 9.

Full name of person(s) subject to the notification obligation: iii Woodford Investment Management LLP (Woodford) 4. Full name of shareholder(s) (if different from 3.): iv Clients of Woodford 5. Date of the transaction and date on which the threshold is crossed or reached: v 15.02.2016 6. Date on which issuer notified: 16.02.2016 7. Threshold(s) that is/are crossed or reached: vi, vii 20% 8.

Additional information: 14. Contact name: Akpene Akonou 15. Contact telephone number: 01865 809024