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Abstract 725. 10. R rvig et al J Leukocyte Biol 94, 711-721 (2013). Treatment Approach4 Typical asthma symptoms; often more severe/resistant to treatment5 Associated with smoking, pollution, infections, obesity5 Sputum LIGHT levels negatively associated with lung function (FEV1 and FVC) in asthma8,9 Higher LIGHT levels in sputum in asthma patients with neutrophilia8 Neutrophils have high pre-formed LIGHT levels10 Patient Population US Prevalence of asthma 25M1 NEA accounts for 47% of asthma2,3 50% of patients with asthma remain controlled4 Standard therapies for asthma; many NEA patients remain uncontrolled6,7 Currently no approved targeted therapies for NEA Signs and Symptoms4 Rationale for AVTX-002 14 Copyright 2022.
Accessed January 3, 2022. 5. Carr, T. F., Zeki, A. A. & Kraft, M. Eosinophilic and Noneosinophilic Asthma. Am J Resp Crit Care 197, 22-37 (2017). 6. Esteban-Gorgojo I et al. J Asthma Allergy. 2018;11:267-281. 7. ClearView Healthcare Partners Analysis, June 2021. 8. Hastie AT et al. J Allergy Clin Immunol. 2010;125(5):1028-1036. 9. Romeo J et al. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.
Non-Eosinophilic Asthma (NEA) 1. Asthma and Allergy Foundation of America. Asthma facts and figures. https://www.aafa.org/asthma-facts/. Accessed January 3, 2022. 2. McGrath KW et al. Am J Resp Crit Care Med. 2012;185(6):612-619. 3. Jiang Y et al. Allergy Asthma Clin Immunol. 2021;17(1):45. 4. Centers for Disease Control and Prevention. AsthmaStats: Uncontrolled asthma among adults, 2016. https://www.cdc.gov/asthma/asthma_stats/uncontrolled-asthma-adults.htm.
S. et al. Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome. J Clin Invest (2021) doi:10.1172/jci153173. LIGHT Levels (pg/mL) Over Treatment Period Percentage of Patients with Respiratory Failure of death by Day 28 AVTX-002 (n=36) Placebo (n=34) LI G HT L ev el s ( pg /m L) 400 300 200 100 0 Day 5Day 1 (Baseline) Day 2 11 Copyright 2022.
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