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Chronic Kidney Disease Stage 3 and 4: one US-listed biotech with a clinical-stage programme

Cardiovascular & MetabolicUncontestedData as of 2026-09-04

Competitors1in the clinic
Median market cap$1.2Buniverse median $1.20B
Allocated capital$601M$1.2B competing
Phase 3 or filed01 mid, 0 early
Pure plays0this indication only
Capital rank193/299crowding rank 203

Chronic Kidney Disease Stage 3 and 4 is uncontested. OPKO Health (OPK) is the only US-listed developer in the $100M to $20B band running a clinical programme here, with CTAP101 in phase 2.

There is no public comparable to price it against. OPK spreads its $1.2B market cap across 2 indications, so $601M of it is allocated here.

Nothing here has reached Phase 3: 1 programme in mid stage and 0 in early stage, so the field is still several years from a first approval.

$601M of allocated capital sits in Chronic Kidney Disease Stage 3 and 4, ranking it 193rd of 299 indications by the money committed to it.

Companies developing drugs for Chronic Kidney Disease Stage 3 and 4 1

TickerCompanyLead assetPhaseTrialsMarket capPure playIndicationsNext catalyst
OPKOPKO HealthCTAP101Phase 21$1.2BNo2 30 Sep 2026

Sorted by phase, then by market capitalisation. Ticker links open the company profile.

Why Chronic Kidney Disease Stage 3 and 4 counts as uncontested

Uncontested. One US-listed developer in the size band is running a clinical programme here, so there is no public comparable to price it against.

The map splits indications on two folds: six or more competitors counts as crowded, and a median company above $1.20B counts as richly priced. Chronic Kidney Disease Stage 3 and 4 has one competitor and a median of $1.2B.

Cardiovascular & Metabolic

Cardiovascular & Metabolic holds $89.7B of the map's capital, 13.4% of the total, spread across 29 indications and 44 companies. 9 of those indications have more than one company competing.

See every Cardiovascular & Metabolic indication on the map

Related indications in Cardiovascular & Metabolic

Long Chain Fatty Acid Oxidation Disorders1 company · $488M · median $1.5BUncontestedProteinuric Kidney Disease1 company · $719M · median $1.4BUncontestedChronic Idiopathic Constipation1 company · $462M · median $924MUncontestedGestational Diabetes1 company · $424M · median $1.3BUncontestedGout1 company · $211M · median $211MUncontestedArrhythmogenic Right Ventricular Cardiomyopathy2 companies · $210M · median $277MOrphan cornerAnemia Associated With Chronic Kidney Disease1 company · $180M · median $1.6BUncontestedAtherosclerotic Cardiovascular Disease Management1 company · $1.0B · median $3.1BUncontested

Chronic Kidney Disease Stage 3 and 4 pipeline questions

Which biotech companies are developing drugs for Chronic Kidney Disease Stage 3 and 4?

OPKO Health (OPK, CTAP101, Phase 2). Those are the 1 US-listed developer in the $100M to $20B market cap band with a clinical-stage programme in Chronic Kidney Disease Stage 3 and 4.

How advanced is the Chronic Kidney Disease Stage 3 and 4 pipeline?

Of the 1 clinical-stage programme in Chronic Kidney Disease Stage 3 and 4, 0 are in Phase 3 or filed, 1 is in mid-stage development and 0 are in early-stage development.

Is anyone else developing a drug for Chronic Kidney Disease Stage 3 and 4?

No. OPK is the only US-listed company in the $100M to $20B market cap band with a clinical-stage programme in Chronic Kidney Disease Stage 3 and 4, which is why the indication is classified as uncontested.

When is the next Chronic Kidney Disease Stage 3 and 4 catalyst?

The next dated catalyst in Chronic Kidney Disease Stage 3 and 4 is OPK on 30 Sep 2026. 1 dated event across the field fall in the next 12 months.

How this page is built

  • Universe is US-listed drug developers with a $100M to $20B market capitalisation, identified by SEC SIC code 2833, 2834 or 2836 or by a pharmaceutical or biotechnology industry classification, less a reviewed exclusion list of contract research organisations, device and diagnostics makers and diversified generics manufacturers.
  • An asset attributed to three or more different companies is treated as shared standard of care rather than any one company’s programme and excluded. Pembrolizumab alone appears under 21 tickers in raw trial data.
  • A programme counts only where at least one industry-sponsored trial supports it, so investigator-initiated academic studies of third-party drugs are excluded.

Allocated capital divides each company’s market capitalisation evenly across the indications it is running clinical programmes in, so every dollar of the universe is counted exactly once. Total market capitalisation competing counts a company in each of its indications and therefore sums to more than the universe.

Third-party market size estimates are not used anywhere on this page. Approved incumbents are excluded from competitor counts, and companies above $20B are outside the universe by construction.

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