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Chronic Heart Failure With Reduced Ejection Fraction: one US-listed biotech with a clinical-stage programme

Cardiovascular & MetabolicUncontestedData as of 2026-09-04

Competitors1in the clinic
Median market cap$9.2Buniverse median $1.20B
Allocated capital$2.3B$9.2B competing
Phase 3 or filed01 mid, 0 early
Pure plays0this indication only
Capital rank85/299crowding rank 117

Chronic Heart Failure With Reduced Ejection Fraction is uncontested. Cytokinetics (CYTK) is the only US-listed developer in the $100M to $20B band running a clinical programme here, with CK-4021586 in phase 2.

There is no public comparable to price it against. CYTK spreads its $9.2B market cap across 4 indications, so $2.3B of it is allocated here.

Nothing here has reached Phase 3: 1 programme in mid stage and 0 in early stage, so the field is still several years from a first approval.

$2.3B of allocated capital sits in Chronic Heart Failure With Reduced Ejection Fraction, ranking it 85th of 299 indications by the money committed to it.

Companies developing drugs for Chronic Heart Failure With Reduced Ejection Fraction 1

TickerCompanyLead assetPhaseTrialsMarket capPure playIndicationsNext catalyst
CYTKCytokineticsCK-4021586Phase 21$9.2BNo4 14 Nov 2026

Sorted by phase, then by market capitalisation. Ticker links open the company profile.

Why Chronic Heart Failure With Reduced Ejection Fraction counts as uncontested

Uncontested. One US-listed developer in the size band is running a clinical programme here, so there is no public comparable to price it against.

The map splits indications on two folds: six or more competitors counts as crowded, and a median company above $1.20B counts as richly priced. Chronic Heart Failure With Reduced Ejection Fraction has one competitor and a median of $9.2B.

Cardiovascular & Metabolic

Cardiovascular & Metabolic holds $89.7B of the map's capital, 13.4% of the total, spread across 29 indications and 44 companies. 9 of those indications have more than one company competing.

See every Cardiovascular & Metabolic indication on the map

Related indications in Cardiovascular & Metabolic

Heart Failure with Decompensation1 company · $2.3B · median $9.2BUncontestedCholestatic Liver Disease1 company · $2.2B · median $6.5BUncontestedATTR Amyloidosis2 companies · $2.0B · median $5.7BConcentrated betPostbariatric Hypoglycemia1 company · $1.9B · median $3.8BUncontestedCardiovascular1 company · $1.8B · median $5.5BUncontestedHypertriglyceridemia2 companies · $2.8B · median $10.9BConcentrated betHyperlipidemia1 company · $1.7B · median $12.2BUncontestedDiabetes9 companies · $3.2B · median $401MKnife fight

Chronic Heart Failure With Reduced Ejection Fraction pipeline questions

Which biotech companies are developing drugs for Chronic Heart Failure With Reduced Ejection Fraction?

Cytokinetics (CYTK, CK-4021586, Phase 2). Those are the 1 US-listed developer in the $100M to $20B market cap band with a clinical-stage programme in Chronic Heart Failure With Reduced Ejection Fraction.

How advanced is the Chronic Heart Failure With Reduced Ejection Fraction pipeline?

Of the 1 clinical-stage programme in Chronic Heart Failure With Reduced Ejection Fraction, 0 are in Phase 3 or filed, 1 is in mid-stage development and 0 are in early-stage development.

Is anyone else developing a drug for Chronic Heart Failure With Reduced Ejection Fraction?

No. CYTK is the only US-listed company in the $100M to $20B market cap band with a clinical-stage programme in Chronic Heart Failure With Reduced Ejection Fraction, which is why the indication is classified as uncontested.

When is the next Chronic Heart Failure With Reduced Ejection Fraction catalyst?

The next dated catalyst in Chronic Heart Failure With Reduced Ejection Fraction is CYTK on 14 Nov 2026. 1 dated event across the field fall in the next 12 months.

How this page is built

  • Universe is US-listed drug developers with a $100M to $20B market capitalisation, identified by SEC SIC code 2833, 2834 or 2836 or by a pharmaceutical or biotechnology industry classification, less a reviewed exclusion list of contract research organisations, device and diagnostics makers and diversified generics manufacturers.
  • An asset attributed to three or more different companies is treated as shared standard of care rather than any one company’s programme and excluded. Pembrolizumab alone appears under 21 tickers in raw trial data.
  • A programme counts only where at least one industry-sponsored trial supports it, so investigator-initiated academic studies of third-party drugs are excluded.

Allocated capital divides each company’s market capitalisation evenly across the indications it is running clinical programmes in, so every dollar of the universe is counted exactly once. Total market capitalisation competing counts a company in each of its indications and therefore sums to more than the universe.

Third-party market size estimates are not used anywhere on this page. Approved incumbents are excluded from competitor counts, and companies above $20B are outside the universe by construction.

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