Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Amlodipine and Benazepril · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| 1 | EXPERIMENTAL | Amlodipine and Benazepril HCl Capsules 10 mg/20 mg |
| 2 | ACTIVE_COMPARATOR | Lotrel® Capsules 10 mg/20 mg |
| Name | Type | Description |
|---|---|---|
| Amlodipine and Benazepril HCl Capsules 10 mg/20 mg | DRUG | 10/120mg, single dose fed |
| Lotrel® Capsules 10 mg/20 mg | DRUG | 10/20mg, single dose fed |
Inclusion Criteria: * 1\. Age: 18 years and older. 2. Sex: Male and/or non-pregnant, non-lactating female. 1. Women of childbearing potential must have negative serum beta-human chorionic gonadotropin (β-HCG) pregnancy tests performed within 14 days prior to the start of the study and on the eve...
Amlodipine and Benazepril is a fixed dose combination product developed by Viatris Inc. (ticker VTRS). It combines amlodipine, a calcium channel blocker, with benazepril, an ACE inhibitor, in a single oral capsule. The specific presentation referenced here is Amlodipine and Benazepril HCl Capsules 10 mg/20 mg.
Amlodipine and Benazepril targets the calcium channel subunits CACNA1C, CACNA1S, CACNA1D, and CACNA1F. Amlodipine acts as a blocker at these L type calcium channels, while benazepril is an ACE inhibitor. This dual mechanism is intended to lower blood pressure through complementary pathways.
Amlodipine and Benazepril is developed by Viatris Inc., which trades under the ticker VTRS. Viatris is the company associated with the Amlodipine and Benazepril HCl Capsules 10 mg/20 mg presentation described in this reference.
Amlodipine and Benazepril is in Phase 1 development. The single registered trial for this asset is a Phase 1 study, and it has been completed. The program is not currently active, with no ongoing trials listed.
Amlodipine and Benazepril has been studied in one completed Phase 1 trial, NCT00649402, titled Fed Study of Amlodipine and Benazepril HCl Capsules 10 mg/20 mg to Lotrel Capsules 10 mg/20 mg. The trial enrolled 64 healthy adult volunteers in the United States and used an active controlled, randomized design.