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AVN-944 for administration

Phase 1

Acute Leukemia | Small molecule | Oncology |Vertex Pharmaceuticals Incorporated|Last Updated: Aug 4, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment72
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00273936Trial of AVN-944 in Patients With Advanced Hematologic MalignanciesPHASE1 COMPLETED 72Jan 1, 2006 -Aug 4, 20115 United States
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
Interventions
NameTypeDescription
AVN-944 capsules for oral administrationDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites5

Inclusion Criteria: 1. Histologically or cytologically confirmed chronic myelogenous leukemia, acute myeloid leukemia, acute lymphocytic leukemia, multiple myeloma, Waldenstrom's macroglobulinemia, non-Hodgkin's lymphoma or Hodgkin's disease. 2. Patients must be refractory to, intolerant of, or dec...

Countries:United States
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